Intracellular membrane traffic; plant transgene expression technology

My laboratory investigates the molecular mechanisms that facilitate the fundamental processes of growth, division, and spatial pattering of plant cells. This has begun to reveal how plant cells have evolved distinctive intracellular transport pathways to perform these tasks. In other work, we have also developed genetic technologies that allow transgene activity to be controlled in space and time in a variety of plant species.

Kirchhelle, C., Chow, C.-M., Foucart, C., Neto, H., Stierhof, Y.-D., Kalde, M., Walton, C., Fricker, M., Smith, Richard S., Jérusalem, A., Irani, I., and Moore, I. (2016). The Specification of Geometric Edges by a Plant Rab GTPase Is an Essential Cell-Patterning Principle During Organogenesis in Arabidopsis. Developmental Cell 36, 386-400 Visscher AM, Belfield EJ, Vlad D, Irani N, Moore I, Harberd NP (2015) Overexpressing the Multiple-Stress Responsive Gene At1g74450 Reduces Plant Height and Male Fertility in Arabidopsis thaliana. PLoS ONE 10(10): e0140368. doi:10.1371/journal.pone.0140368 Au, K.K.C, Perez-Gomez, J, Neto, H, Muller, C, Meyer, A.J, Fricker, M.D, Moore, I. (2012) A perturbation in glutathione biosynthesis disrupts endoplasmic reticulum morphology and secretory membrane traffic in Arabidopsis thaliana Plant Journal. 71 (6): pp 881-894. doi:10.1111/j.1365-313X.2012.05022.x. Boutte, Y, Frescatada-Rosa, M, Men, S, Chow, C.-M, Ebine, K, Gustavsson, A, Johansson, L, Ueda, T, Moore, I, Jurgens, G, Grebe, M. (2010) Endocytosis restricts Arabidopsis KNOLLE syntaxin to the cell division plane during late cytokinesis EMBO Journal. 29 (3): pp 546-558. doi:10.1038/emboj.2009.363. da, Costa D.S, Pereira, S, Moore, I, Pissarra, J. (2010) Dissecting cardosin B trafficking pathways in heterologous systems Planta. 232 (6): pp 1517-1530. doi:10.1007/s00425-010-1276-9. Camacho, L, Smertenko, A.P, Perez-Gomez, J, Hussey, P.J, Moore, I. (2009) Arabidopsis Rab-E GTPases exhibit a novel interaction with a plasma-membrane phosphatidylinositol-4-phosphate 5-kinase Journal of Cell Science. 122 (23): pp 4383-4392. doi:10.1242/jcs.053488.