The interest of the Molecular Medicine Lab is to monitor and modulate the effectors of disease with a diverse toolbox of molecular innovations for the advancement of medicine. Using novel strategies for controlling small molecule activity and disposition in living subjects at the sites of disease (e.g. self-assembly), novel therapeutics and imaging probes will be developed with the goal of clinical translation.

Biochemistry of Disease Molecular Therapeutics Molecular Imaging Self-Assembly MRI PET

The interest of the Molecular Medicine Lab is to monitor and modulate the effectors of disease with a diverse toolbox of molecular innovations for the advancement of medicine. Using novel strategies for controlling small molecule activity and disposition in living subjects at the sites of disease (e.g. self-assembly), novel therapeutics and imaging probes will be developed with the goal of clinical translation.

Ye D*, Shuhendler AJ*, Cui L, Tong L, Tee SS, Tikhomirov G, Felsher D, Rao J. Bioorthogonal Cyclization and In Situ Self-Assembly of Small Molecule Probes for Imaging Caspase Activity in Living Mice. Nature Chemistry. 2014, 6:519. Shuhendler AJ*, Pu KY*, Cui L, Uetrecht JP, Rao J. Real-Time, Two-Channel Imaging of Drug-Induced Hepatic Oxidative and Nitrosative Stress with Nanosensors. Nature Biotechnology. 2014, 32:373. Pu KY*, Shuhendler AJ*, Jokerst JV, Mei J, Gambhir SS, Bao Z, Rao J. Semiconducting Polymer Nanoparticles as Photoacoustic Molecular Imaging Probes in Living Mice. Nature Nanotechnology 2014, 9:233.