Validation of the applicability of high-content molecular biology tools, such as genomics (transcriptomics, proteomics, secretomics) in hazard identification, risk calculation and deriving regulatory oversights for human risk of exposure to environmental chemicals including engineered nanomaterials.

Sarah Labib, Charles H Guo, Andrew Williams, Carole L Yauk, Paul A White, Sabina Halappanavar*. Toxicogenomic outcomes predictive of forestomach carcinogenesis following exposure to benzo(a)pyrene: relevance to human cancer risk. Toxicology and Applied Pharmacology, in press, 2013 Husain M, Saber AT, Guo C, Jacobsen NR, Jensen KA, Yauk CL, Williams A, Vogel U, Wallin H, Halappanavar S*. Pulmonary instillation of low doses of titanium dioxide nanoparticles in mice leads to particle retention and gene expression changes in the absence of inflammation. Toxicolology and Applied Pharmacology Jun 15;269(3):250-62, 2013 Andrea Rowan-Carroll A, Halappanavar S*, Williams A, Somers CM, Yauk CL.. Mice exposed in situ to urban air pollution exhibit pulmonary alterations in gene expression in the lipid droplet synthesis pathways. Environ Mol Mutagen. May;54(4):240-9, 2013 Happanavar S*, Nikota J, Wu D, Williams A, Yauk CL, Stampfli M.. IL-1 receptor regulates microRNA-135b expression in a negative feedback mechanism during cigarette smoke-induced inflammation. J Immunol. 2013 Apr 1;190(7):3679-86, 2013 Jackson P, Halappanavar S, Hougaard KS, Williams A, Madsen AM, Lamson JS, Andersen O, Yauk C, Wallin H, Vogel U.. Maternal inhalation of surface-coated nanosized titanium dioxide (UV-Titan) in C57BL/6 mice: effects in prenatally exposed offspring on hepatic DNA damage and gene expression. Nanotoxicology. 2013 Feb;7(1):85-96, 2013