Through his research programs, Dr. Bryce develops and applies NMR spectroscopic and quantum chemical methods for the study of nuclei in unique bonding environments in diverse inorganic and bioinorganic systems. One of the goals is to establish tools for providing new insights into compounds ranging from supramolecular materials to ion transport channels. In addition to providing fundamentally new chemical knowledge on structure and bonding in such systems, one of the aims is to establish solid-state NMR as more of a predictive tool in the characterization of inorganic and bioinorganic molecules. The development of new tools for NMR spectroscopic biomolecular structure determination (proteins, nucleic acids) is also an ongoing area of interest.

Through his research programs, Dr. Bryce develops and applies NMR spectroscopic and quantum chemical methods for the study of nuclei in unique bonding environments in diverse inorganic and bioinorganic systems. One of the goals is to establish tools for providing new insights into compounds ranging from supramolecular materials to ion transport channels. In addition to providing fundamentally new chemical knowledge on structure and bonding in such systems, one of the aims is to establish solid-state NMR as more of a predictive tool in the characterization of inorganic and bioinorganic molecules. The development of new tools for NMR spectroscopic biomolecular structure determination (proteins, nucleic acids) is also an ongoing area of interest.

solid-state NMR spectroscopy of low-frequency quadrupolar nuclei, halogen bonding, double-rotation NMR, biomolecular NMR spectroscopy, solid-state NMR of inorganic and bioinorganic systems, mechanochemistry, interpretation and quantum chemical calculation of NMR interaction tensors.

J. Viger-Gravel, S. Leclerc, I. Korobkov, and D. L. Bryce. Direct Investigation of Halogen Bonds by Solid-State Multinuclear Magnetic Resonance Spectroscopy and Molecular Orbital Analysis. J. Am. Chem. Soc., 136, 6929-6942, 2014 K. M. N. Burgess, Y. Xu, M. C. Leclerc, and D. L. Bryce. Insight into Magnesium Coordination Environments in Benzoate and Salicylate Complexes through 25Mg Solid-State NMR Spectroscopy. J. Phys. Chem. A, 117, 6561-6570, 2013 F. A. Perras and D. L. Bryce. Symmetry-Amplified J Splittings for Quadrupolar Spin Pairs: A Solid-State NMR Probe of Homoatomic Covalent Bonds. J. Am. Chem. Soc., 135, 12596-12599, 2013 K. M. N. Burgess, F. A. Perras, A. Lebrun, E. Messner-Henning, I. Korobkov, and D. L. Bryce. Sodium-23 Solid-State Nuclear Magnetic Resonance of Commercial Sodium Naproxen and its Solvates. J. Pharm. Sci., 101, 2930-2940, 2012 C. M. Widdifield, A. D. Bain, and D. L. Bryce. Definitive Solid-State 185/187Re NMR Spectral Evidence for and Analysis of the Origin of High-Order Quadrupole-Induced Effects for I = 5/2. Phys. Chem. Chem. Phys., 13, 12413-12420, 2011