Ph.D., Harvard University B.Sc., University of California, Los Angeles

Biochemistry/Molecular Biology

The Libuda Lab investigates how developing sperm and eggs repair DNA breaks with the proper chromosome template to ensure faithful genome inheritance from one generation to another.

Mara Schvarzstein, Divya Pattabiraman, Diana E. Libuda, Ajit Ramadugu, Angela Tam, Enrique Martinez-Perez, Baptiste Roelens, Karl Zawadzki, Rayka Yokoo, Simona Rosu, Kentaro Nabeshima, and Anne M. Villeneuve (2014). DNA helicase HIM-6/BLM promotes MutSγ-dependent crossovers and antagonizes MutSγ-independent interhomolog associations during C. elegans meiosis. Genetics, 198(1):193-207, doi:10.1534/genetics.114.161513 Diana E. Libuda, Satoru Uzawa, Barbara J. Meyer, and Anne M. Villeneuve (2013). Meiotic chromosome structures constrain and respond to designation of crossover sites. Nature 502, 703-706. Simona Rosu, Karl A. Zawadzki, Ericca L. Stamper, Diana E. Libuda, Angela L. Reese, Abby F. Dernburg, and Anne M. Villeneuve (2013). The C. elegans DSB-2 protein reveals a regulatory network that controls competence for meiotic DSB formation. PLoS Genetics 9(8): e1003674. Simona Rosu, Diana E. Libuda, and Anne M. Villeneuve (2011). Robust crossover assurance and regulated interhomolog access maintain meiotic crossover number. Science 334, 1286-9. Diana E. Libuda and Fred Winston (2010). Alterations in DNA replication and histone levels promote histone gene amplification in Saccharomyces cerevisiae. Genetics, 184, 985-97. Diana E. Libuda and Fred Winston (2006). Amplification of histone genes by circular chromosome formation in Saccharomyces cerevisiae. Nature, 443, 1003-7. Sanja Ivkovic, Byeong S. Yoon, Steven N. Popoff, Fayez F. Safadi, Diana E. Libuda, Robert C. Stephenson, Aaron Daluiski, and Karen M. Lyons (2003). Connective Tissue Growth Factor is an essential regulator of skeletal development.

Development, 130, 2779-91.