Professional Appointments: 07/2020–present Associate Professor, Department of Chemistry and Biochemistry,University of Oklahoma, Norman, OK 08/2014–06/2020 Assistant Professor, Department of Chemistry and Biochemistry,University of Oklahoma, Norman, OK 08/2014–present Full Member, Institute of Natural Products Applications and Research Technologies (INPART), University of Oklahoma, Norman, OK 09/2015-2021 Associated Faculty, Cellular and Behavioral Neurobiology, University of Oklahoma, Norman, OK 07/2013-07/2014 Lecturer, Weill Cornell Graduate College, New York Education and Training 02/2011–07/2014 Lucille Castori Postdoctoral Fellow with Prof. Derek S. Tan, Memorial Sloan–Kettering Cancer Center (MSKCC), New York “Diversity-oriented synthesis of benzannulated spiroketals and Rational design of novel antibiotics” 08/2006–01/2011 Ph.D. in Chemistry with Prof. David Crich at Wayne State University, MI and University of Illinois at Chicago, IL “Chemical synthesis of peptides and peptide thioesters along with mechanistic studies of glycosylation reactions.” 07/2004–06/2006 M.Sc. in Chemistry with Prof. Dipakranjan Mal at IIT Kharagpur, India “[4 + 2] Hauser annulation for the synthesis of anticancer anthracyclines.” 07/2001–06/2004 B.Sc. (Honors) in Chemistry, University of Delhi, India

His research focuses on the development of new synthetic methods based on metal-carbene chemistry and their applications in total synthesis and drug discovery.

Singh, SP; Chaudhary, U; Daróczi, A; Sharma, I “Fe(OTf)3 or Photosensitizer-Free Blue Light Activated Diazo-Thioglycoside Donors for Iterative and Stereoselective Glycosylations” Nature Communications 2025 Just Accepted! Ghosh, B; Kafle, P; Mukherjee, R; Welles, R; Herndon, D; Nicholas, KM; Shao, Y; Sharma, I. “Sulfenylnitrene-mediated nitrogen-atom insertion for late-stage skeletal editing of N-heterocycles” Science, 2025, 378(6729), 102-107 Singh, SP; Herndon, D; Chatterjee, U; Nicholas, KM; Sharma, I. “Investigating the Reactivity of Nitrous Oxide with Hydrazines: Application to the Synthesis of Diarylethanes from Diarylmethylhydrazines” New Journal of Chemistry, 2025, 49, 1182 - 1188 DOI: 10.1039/d4nj04837g Singh, SP; Chuadhary, U; Sharma, I. “Catalytic Thioglycoside Activation with Diazo-Derived Copper Carbenes” Molecules 2024, 29(22), 5367 DOI: 10.3390/molecules29225367 Ghosh, B; Alber, A; Lander, C.W.; Shao, Y; Nicholas, K.M.; Sharma, I. “Catalytic Activation of Thioglycosides with Copper-Carbenes for Stereoselective 1,2-Cis-Furanosylations” Org. Lett. 2024, 26, 9436-9441 DOI: 10.1021/acs.orglett.4c03281 Kafle, P; Herndon, D; Sharma, I. “Inverting Conventional Chemoselectivity of Metal Carbenes with Sulfenylcarbenes for Late-Stage Functionalizations” 2024, ChemRxiv, Preprint Available! DOI: 10.26434/chemrxiv-2024-6dncp Ghosh, B; Kafle, P; Mukherjee, R; (equal contributors BG, PK, RM); Welles, R; Herndon, D; Nicholas, K.M.; Shao, Y; Sharma, I. “Sulfenylnitrene-Mediated Nitrogen-Atom Insertion into Pyrroles, Indoles, and Imidazoles” 2024, ChemRxiv, Preprint Available! DOI: 10.26434/chemrxiv-2024-f80wf-v2 Bain, A. I.; Massaro, N. P.; Chinthapally, K.; Sharma, I. “Vinyl Metal Carbene Initiated Cascade Reactions for the Synthesis of Carbo- and Hetero-cycles” 2025 (submitted). Singh, SP; Ghosh, B; (equal contributions SPS, BG) Sharma, I. “Catalytic Orthogonal Glycosylation Enabled by Enynal-Derived Copper Carbenes” Adv. Synth. Catal. 2024 DOI: 10.1002/adsc.202301207 Kafle, P.; Ghosh, B.; Hunter, A.; Mukherjee, R.; (equal contributions BG, AH, RM) Nicholas, K. M.; Sharma, I. “Iron-carbene initiated O–H Insertion/Aldol Cascade for the Stereoselective Synthesis of Functionalized Tetrahydrofurans” ACS Catal. 2024, 14, 1292–1299 DOI: 10.1021/acscatal.3c05040 Ghosh, B.; Alber, A.; Lander, C.; Shao, Y.; Nicholas, K. M.; Sharma, I. “Catalytic Stereoselective 1,2-cis Furanosylations Enabled by Enynal-Derived Copper Carbenes” ACS Catal. 2024, 14, 1037–1049 DOI: 10.1021/acscatal.3c05237 OU, C.; Ghosh, B.; Sharma, I. “A Non-Diazo Approach to Functionalized (2-furyl)-2-pyrrolidines through a Cascade Reaction of Enynal-Derived Zinc Carbenoids with b-Aminoketones” Org. Chem. Front., 2023, 10, 5933 - 5939. DOI: 10.1039/d3qo01354e Bain, A. I.; Chinthapally, K.; Hunter, A. C.; (equal contributions AB, KC, AH) Sharma, I. “Dual Catalysis in Rhodium (II) Carbenoid Chemistry” Eur. J. Org. Chem. 2022 (DOI: 10.1002/ejoc.202101419; Selected for the Front Cover Page). Paymode, D. J.; Sharma, I. Rhodium‐Catalyzed [3+2]‐ANNULATION of Ortho‐ Diazoquinones WITH Enol ETHERS: Diversity‐Oriented Total Synthesis OF AFLATOXIN B2. European Journal of Organic Chemistry 2021, 13, 2034–2040. DOI: 10.1002/ejoc.202100186 Schlitzer, S.; Stevens, K.; Sharma, I. “A Metal Free Aromative Cascade for the Synthesis of Diverse Heterocycles” Org. Chem. Front. 2020 (DOI: 10.1039/c9qo01336a; Selected for the Front Cover Page). Chinthapally, K.; Massaro, N.; Sabrina, T.; Gardner, E.; Sharma, I. “Trapping Rhodium Vinylcarbenoids with Aminochalcones for the Synthesis of Medium-Sized Azacycles” Tetrahedron Letters 2019, 60, 151253. DOI: 10.1016/j.tetlet.2019.151253 Massaro, N.; Chatterji, A.; Sharma, I. “A three Component Approach to Pyridine Stabilized Keteneimines for the Synthesis of Diverse Heterocycles” J. Org. Chem. 2019, 84, 13676–13685. DOI: 10.1021/acs.joc.9b01906 Hunter, A. C.; Chinthapally, K.; Bain, A.; Steven, J. C.; Sharma, I. "Rh/Au Dual Catalysis in Carbene sp2-CH Functionalization/Conia-ene Cascade to the Stereoselective Synthesis of Diverse Spirocarbocycles” Adv. Synth. Catal. 2019, 361, 2951–2958. DOI: 10.1002/adsc.201900079 In collaboration with NIH-NCATS Library Screening Program: "Canvall: a Crowd-Sourced Natural Product Screening Library for Exploring Biological Space” ACS Cent. Sci. 2018, 4, 1727–1741. DOI: 10.1021/acscentsci.8b00747 Massaro, N. P.; Stevens, J. C.; Chatterji, A.; “Stereoselective Synthesis of Diverse Lactones through Diverted Carbene Ketoacid Insertion Reactions” Org. Lett. 2018, 20, 7585–7589. DOI: 10.1021/acs.orglett.8b03327 Hunter, A. C.; Almutwalli, B.; Bain, A.; Sharma, I. "Trapping Rhodium Carbenoids with Aminoalkynes for the Synthesis of Diverse N-Heterocycles” Tetrahedron 2018, 74, 5451–5457. DOI: 10.1016/j.tet.2018.06.042 (Invited article in honor of Derek Barton on his centennial birthday). Hunter, A.C.; Schlitzer, S.C.; Stevens, J.C.; Almutwalli, B.; Sharma, I. “A Convergent Approach to Diverse Spiroethers through Stereoselective Trapping of Rhodium Carbenoids with Gold Activated Alkynols” J. Org. Chem. 2018, 83, 2744–2752. DOI: 10.1021/acs.joc.7b03196 Chinthapally, K.; Massaro, N.; Padgett, H.L.; Sharma, I. “A Serendipitous Cascade of Rhodium Vinylcarbenoids with Aminochalcones for the Synthesis of Functionalized Quinolines” Chem. Comm. 2017, 53, 12205–12208. DOI: 10.1039/C7CC07181G Chinthapally, K; Massaro, N. P.; Sharma, I. “Rhodium Carbenoid Initiated O–H Insertion/Aldol/Oxy-Cope Cascade for the Stereoselective Synthesis of Functionalized Oxacycles” Org. Lett. 2016, 18, 6340–6343. DOI: 10.1021/acs.orglett.6b03229 Hunter, A. C.; Schlitzer, S. C.; Sharma, I. “Synergistic Diazo–OH Insertion/Conia-Ene Cascade Catalysis for the Stereoselective Synthesis of γ-Butyrolactones and tetrahydrofurans” Chem. Eur. J. 2016, 22, 16062–16065 DOI: 10.1002/chem.201603934. In Collaboration with Professor Lakshmi Devi (Mount Sinai, New York) and Joseph Parello (Vanderbilt University); Gupta, A.; Gomes, I.; Bobeck, E. N.; Fakira, A. K.; Massaro, N. P.; Sharma, I.; Cave, A.; Hamm, H. E.; Parello, J.; Devi, L. A. “Collybolide is a Novel Biased Agonist of κ-Opioid Receptors with Potent Antipruritic Activity” Proc. Natl. Acad. Sci. 2016, 113, 6041–6 DOI: 10.1073/pnas.1521825113 Hunter, A. C.; Chinthapally, K.; Sharma, I. “Rh2(esp)2: An Efficient Catalyst for O–H Insertion Reactions of Carboxylic Acids into Acceptor/Acceptor Diazo Compounds” Eur. J. Org. Chem. 2016, 2260–2263, selected for the front cover page; DOI: 10.1002/ejoc.201600064 Ji, C.; Sharma, I.; Pratihar, D.; Hudson, L. L.; Maura, D.; Guney, T.; Rahme, L. G.; Pesci, E. C.; Coleman, J. P.; Tan, D. S. “Designed small-molecule inhibitors of the anthranilyl-CoA synthetase PqsA block quinolone biosynthesis in Pseudomonas aeruginosa” ACS Chem. Biol. 2016, 11, 3061–3067. DOI: 10.1021/acschembio.6b00575 Matarlo, J. S.; Evans, E. C.; Sharma, I.; Lavaud, L. J.; Ngo, S. C.; Shek, R.; Rajashankar, K. R.; French, J. B.; Tan, D. S.; Tonge, P. J. “Mechanism of MenE Inhibition by Acyl-Adenylate Analogues and Discovery of Novel Antibacterial Agents” Biochemistry 2015, 54, 6514–6524. DOI: 10.1021/acs.biochem.5b00966 Sharma, I.; Wurst, J.; Tan, D. S. “ Solvent-Dependent Divergent Functions of Sc(OTf)­3 in Stereoselective Epoxide-Opening Spiroketalizations” Org. Lett. 2014, 16, 2474–2477. DOI: 10.1021/ol500853q In collaboration with Dr. Susruta Majumdar (Pasternak Lab, MSKCC), Váradi, A.; Palmer, T. C.; Notis, P. R.; Redel-Traub, G. N.; Afonin, D.; Subrath, J. J.; Pasternak, G. W.; Hu, C.; Sharma, I.; Majumdar, S.; “Three-Component Coupling Approach for the Synthesis of Diverse Heterocycles Utilizing Reactive Nitrilium Trapping” Org. Lett. 2014, 16, 1668–1671. DOI: 10.1021/ol500328t Sharma, I.; Tan, D. S. News and Views “Drug Discovery Diversifying Complexity” Nature Chemistry 2013, 5, 157–158. DOI: 10.1038/nchem.1581 Lu, X.; Zhou, R.; Sharma, I.; Li, X.; Kumar, G.; Swaminathan, S.; Tonge, P. J.; Tan, D. S. “Stable Analogues of OSB-AMP: Potent Inhibitors of MenE, the o-Succinylbenzoate-CoA Synthetase from Bacterial Menaquinone Biosynthesis” ChemBioChem. 2012, 13, 129–136. DOI: 10.1002/cbic.201100585 Sharma, I.; Bohe, L.; Crich D. “Influence of Protecting Groups on the Anomeric Equilibrium; Case of the 4,6-O-Benzylidene Acetal in the Mannopyranose Series” Carbohydr. Res. 2012, 357, 126–131. DOI: 10.1016/j.carres.2012.05.025 Sharma, I.; Crich D. “Direct Fmoc-Chemistry-Based Solid Phase Synthesis of Peptidyl Thioesters” J. Org. Chem. 2011, 76, 6518–6524. DOI: 10.1021/jo200497j Aubry, S.; Sasaki, K.; Sharma, I.; Crich, D. "Influence of protecting groups on the reactivity and selectivity of glycosylation: Chemistry of the 4,6-O-benzylidene protected mannopyranosyl donors and related species" Topics Curr. Chem. 2011, 301, 141–188. DOI: 10.1007/128_2010_102 Crich, D.; Sharma, I. “Influence of the O3 Protecting Group on Stereoselectivity in the Preparation of C-Mannopyranosides with 4,6-O-Benzylidene Protected Donors” J. Org. Chem. 2010, 75, 8383–8391. DOI: 10.1021/jo101453y Crich, D.; Sharma, I. “Triblock Peptide and Peptide Thioester Synthesis with Reactivity-Differentiated Sulfonamides and Peptidyl Thioacids” Angew. Chem. Int. Ed. 2009, 48, 7591–7594. DOI: 10.1002/anie.200903050 Crich, D.; Sharma, I. "Epimerization-Free Block Synthesis of Peptides from Thioacids and Amines with Sanger’s and Mukaiyama’s Reagents” Angew. Chem. Int. Ed. 2009, 48, 2355–2358. DOI: 10.1002/anie.200805782 Crich, D.; Sharma, I. “Is Donor-Acceptor Hydrogen Bonding Necessary for 4,6-O-Benzylidene Directed β-Mannopyranosylation. Stereoselective Synthesis of β-C-Mannopyranosides and α-C-Glucopyaronosides” Org. Lett. 2008, 10, 4731–4734. DOI: 10.1021/ol8017038 Mal, D.; Ray, S.; Sharma, I. "Direct Access to 1,4-Dihydroxyanthraquinones: The Hauser Annulation Reexamined with p-Quinones” J. Org. Chem. 2007, 72, 4981–4984. DOI: 10.1021/jo062271j