Tighe, Paddy
Associate Professors
所属大学: University of Nottingham
所属学院: School of Life Sciences
邮箱:
paddy.tighe@nottingham.ac.uk
个人主页:
http://www.nottingham.ac.uk/life-sciences/people/paddy.tighe
近期论文
F SALAZAR, L HALL, OH NEGM, D AWUAH, P TIGHE, F SHAKIB and AM GHAEMMAGHAMI, 2016. The mannose receptor negatively modulates the Toll-like receptor 4-aryl hydrocarbon receptor-indoleamine 2,3-dioxygenase axis in dendritic cells affecting T helper cell polarization. J Allergy Clin Immunol. 137(6), 1841-1851 NEGM, O. H., MUFTAH, A. A., ALESKANDARANY, M. A., HAMED, M. R., AHMAD, D. A., NOLAN, C. C., DIEZ-RODRIGUEZ, M., TIGHE, P. J., ELLIS, I. O., RAKHA, E. A. and GREEN, A. R., 2016. Clinical utility of reverse phase protein array for molecular classification of breast cancer: Breast Cancer Res Treat Breast cancer research and treatment. 155(1), 25-35 ALESKANDARANY, M. A., AGARWAL, D., NEGM, O. H., BALL, G., ELMOUNA, A., ASHANKYTY, I., NUGLOZEH, E., FAZALUDEEN, M. F., DIEZ-RODRIGUEZ, M., NOLAN, C. C., TIGHE, P. J., GREEN, A. R., ELLIS, I. O. and RAKHA, E. A., 2016. The prognostic significance of STAT3 in invasive breast cancer: analysis of protein and mRNA expressions in large cohorts: Breast Cancer Res Treat Breast cancer research and treatment. SENTHOORAN SELVARAJAH, IAN TODD, PATRICK TIGHE, MICHELLE JOHN, CHARLOTTE E. BOLTON, TIM HARRISON and LUCY FAIRCLOUGH, 2016. Multiple circulating cytokines are co-elevated in chronic obstructive pulmonary disease. (In Press.) SALAZAR, F., HALL, L., NEGM, O. H., AWUAH, D., TIGHE, P. J., SHAKIB, F. and GHAEMMAGHAMI, A. M., 2016. The mannose receptor negatively modulates the Toll-like receptor 4-aryl hydrocarbon receptor-indoleamine 2,3-dioxygenase axis in dendritic cells affecting T helper cell polarization: J Allergy Clin Immunol J Allergy Clin Immunol. 137(6), 1841-1851 e2 ABDULJABBAR R, AL-KAABI MM, NEGM OH, JERJEES D, MUFTAH AA, MUKHERJEE A, LAI CF, BULUWELA L, ALI S, TIGHE PJ, GREEN A, ELLIS I and RAKHA E, 2015. Prognostic and biological significance of peroxisome proliferator-activated receptor-gamma in luminal breast cancer. Breast cancer research and treatment. 150(3), 511-22 ABDULJABBAR R, NEGM OH, LAI C, JERJEES DA, AL-KAABI M, HAMED MR, TIGHE PJ, BULUWELA L, MUKHERJEE A, GREEN AR, ALI S, RAKHA EA and ELLIS IO, 2015. Clinical and biological significance of glucocorticoid receptor (GR) expression in breast cancer. Breast cancer research and treatment. 150(2), 335-46 JERJEES DA, NEGM OH, ALABDULLAH ML, MIRZA S, ALKAABI M, HAMEED MR, ABDULJABBAR R, MUFTAH A, NOLAN CC, GREEN AR, TIGHE PJ, BAND V, ELLIS IO and RAKHA EA, 2015. The mammalian target of rapamycin complex 1 (mTORC1) in breast cancer: the impact of oestrogen receptor and HER2 pathways. Breast cancer research and treatment. 150(1), 91-103 JEAN-GILLES L, BRAITCH M, LATIF ML, ARAM J, FAHEY AJ, EDWARDS LJ, ROBINS RA, TANASESCU R, TIGHE PJ, GRAN B, SHOWE LC, ALEXANDER SP, CHAPMAN V, KENDALL DA and CONSTANTINESCU CS, 2015. Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells. Acta physiologica (Oxford, England). 214(1), 63-74 VILISAAR J, KAWABE K, BRAITCH M, ARAM J, FURTUN Y, FAHEY AJ, CHOPRA M, TANASESCU R, TIGHE PJ, GRAN B, POTHOULAKIS C and CONSTANTINESCU CS, 2015. Reciprocal Regulation of Substance P and IL-12/IL-23 and the Associated Cytokines, IFNγ/IL-17: A Perspective on the Relevance of This Interaction to Multiple Sclerosis. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. PMID: 25690155, ALSHAREEDA, A. T., NEGM, O. H., GREEN, A. R., NOLAN, C. C., TIGHE, P., ALBARAKATI, N., SULTANA, R., MADHUSUDAN, S., ELLIS, I. O. and RAKHA, E. A., 2015. KPNA2 is a nuclear export protein that contributes to aberrant localisation of key proteins and poor prognosis of breast cancer: Br J Cancer Br J Cancer. 112(12), 1929-37 VILISAAR, J., KAWABE, K., BRAITCH, M., ARAM, J., FURTUN, Y., FAHEY, A. J., CHOPRA, M., TANASESCU, R., TIGHE, P. J., GRAN, B., POTHOULAKIS, C. and CONSTANTINESCU, C. S., 2015. Reciprocal Regulation of Substance P and IL-12/IL-23 and the Associated Cytokines, IFNgamma/IL-17: A Perspective on the Relevance of This Interaction to Multiple Sclerosis: J Neuroimmune Pharmacol J Neuroimmune Pharmacol. TIGHE, P. J., RYDER, R. R., TODD, I. and FAIRCLOUGH, L. C., 2015. ELISA in the multiplex era: potentials and pitfalls: Proteomics Clin Appl Proteomics Clin Appl. 9(3-4), 406-22 NEGM, O. H., HAMED, M. R., DILNOT, E. M., SHONE, C. C., MARSZALOWSKA, I., LYNCH, M., LOSCHER, C. E., EDWARDS, L. J., TIGHE, P. J., WILCOX, M. H. and MONAGHAN, T. M., 2015. Profiling Humoral Immune Responses to Clostridium difficile-Specific Antigens by Protein Microarray Analysis: Clin Vaccine Immunol Clin Vaccine Immunol. JERJEES, D. A., NEGM, O. H., ALABDULLAH, M. L., MIRZA, S., ALKAABI, M., HAMEED, M. R., ABDULJABBAR, R., MUFTAH, A., NOLAN, C. C., GREEN, A. R., TIGHE, P. J., BAND, V., ELLIS, I. O. and RAKHA, E. A., 2015. The mammalian target of rapamycin complex 1 (mTORC1) in breast cancer: the impact of oestrogen receptor and HER2 pathways: Breast Cancer Res Treat Breast cancer research and treatment. 150(1), 91-103 JEAN-GILLES, L., BRAITCH, M., LATIF, M. L., ARAM, J., FAHEY, A. J., EDWARDS, L. J., ROBINS, R. A., TANASESCU, R., TIGHE, P. J., GRAN, B., SHOWE, L. C., ALEXANDER, S. P., CHAPMAN, V., KENDALL, D. A. and CONSTANTINESCU, C. S., 2015. Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells: Acta Physiol (Oxf) Acta Physiol (Oxf). 214(1), 63-74 HEATH, C. J., DEL MAR CENDRA, M., WATSON, A., AUGER, J. P., PANDEY, A., TIGHE, P. and CHRISTODOULIDES, M., 2015. Co-Transcriptomes of Initial Interactions In Vitro between Streptococcus Pneumoniae and Human Pleural Mesothelial Cells: PLoS One PLoS One. 10(11), e0142773 GRECO, E., AITA, A., GALOZZI, P., GAVA, A., SFRISO, P., NEGM, O. H., TIGHE, P., CASO, F., NAVAGLIA, F., DAZZO, E., DE BORTOLI, M., RAMPAZZO, A., OBICI, L., DONADEI, S., MERLINI, G., PLEBANI, M., TODD, I., BASSO, D. and PUNZI, L., 2015. The novel S59P mutation in the TNFRSF1A gene identified in an adult onset TNF receptor associated periodic syndrome (TRAPS) constitutively activates NF-kappaB pathway: Arthritis Res Ther Arthritis Res Ther. 17(1), 93 GALOZZI, P., NEGM, O., GRECO, E., ALKHATTABI, N., GAVA, A., SFRISO, P., FAIRCLOUGH, L., TODD, I., TIGHE, P. and PUNZI, L., 2015. Ex vivo and in vitro production of pro-inflammatory cytokines in Blau syndrome: Reumatismo Reumatismo. 66(4), 277-84 FAIRCLOUGH, L. C., STOOP, A. A., NEGM, O. H., RADFORD, P. M., TIGHE, P. J. and TODD, I., 2015. Tumor Necrosis Factor Receptor I blockade shows that TNF-dependent and independent mechanisms synergise in TNF Receptor Associated Periodic Syndrome: Eur J Immunol Eur J Immunol. DAFFA, N. I., TIGHE, P. J., CORNE, J. M., FAIRCLOUGH, L. C. and TODD, I., 2015. Natural and disease-specific autoantibodies in chronic obstructive pulmonary disease: Clin Exp Immunol Clin Exp Immunol. 180(1), 155-63 ABDULJABBAR, R., NEGM, O. H., LAI, C. F., JERJEES, D. A., AL-KAABI, M., HAMED, M. R., TIGHE, P. J., BULUWELA, L., MUKHERJEE, A., GREEN, A. R., ALI, S., RAKHA, E. A. and ELLIS, I. O., 2015. Clinical and biological significance of glucocorticoid receptor (GR) expression in breast cancer: Breast Cancer Res Treat Breast cancer research and treatment. 150(2), 335-46 ABDULJABBAR, R., AL-KAABI, M. M., NEGM, O. H., JERJEES, D., MUFTAH, A. A., MUKHERJEE, A., LAI, C. F., BULUWELA, L., ALI, S., TIGHE, P. J., GREEN, A., ELLIS, I. and RAKHA, E., 2015. Prognostic and biological significance of peroxisome proliferator-activated receptor-gamma in luminal breast cancer: Breast Cancer Res Treat Breast cancer research and treatment. 150(3), 511-22 ALSHAREEDA AT, NEGM OH, GREEN AR, NOLAN C, TIGHE P, ALBARAKATI N, SULTANA R, MADHUSUDAN S, ELLIS IO and RAKHA EA, 2014. SUMOylation proteins in breast cancer. Breast cancer research and treatment. 144(3), 519-30 ALESKANDARANY MA, NEGM OH, GREEN AR, AHMED MAH, NOLAN CC, TIGHE PJ, ELLIS IO and RAKHA EA, 2014. Epithelial mesenchymal transition in early invasive breast cancer: an immunohistochemical and reverse phase protein array study. Breast cancer research and treatment. 145(2), 339-48