I am an Analytical Chemist and obtained my PhD in Chemistry from the University of Manchester under the supervision of Professor Royston Goodacre. In 2010, I took up a position of Postdoctral Research Assistant at the University of Glasgow. Then I was appointed to a lectureship in Analytical Bioscience at Nottingham in 2013.

Biomarker of disease / drug discovery using MS-based global metabolite profiling Metabolic pathway profiling (targeted and stable isotope assisted analysis) Ambient imaging of biological tissues by mass spectrometry Absolute quantification using heavy atom labelled organism Metabolic flux analysis

My research interest is the method development for MS-based metabolomics in order to investigate complex biological and/or clinical problems. The method development involves metabolic quenching, metabolite extraction and LC-MS analytical conditions. These methods will be applied to selected cells or tissues for metabolite profiling to identify metabolic pathways, which are targeted by various perturbations. This novel methodology will then be applied to study specific diseases in order to monitor disease onset and progress, and to identify diagnostic biomarkers. These biomarkers can be used for new targets for chemotherapy and the development of new drugs.

SURRATI, AMAL, LINFORTH, R, FISK, IAN DENIS, SOTTILE, VIRGINIE and KIM, DONG-HYUN, 2016. Non-destructive characterisation of mesenchymal stem cell differentiation using LC-MS-based metabolite footprinting Analyst. 141, 3776-3787 ALKHALDI AAM, CREEK DJ, IBRAHIM H, KIM D, QUASHIE NB, BURGESS KE, CHANGTAM C, BARRETT MP, SUKSAMRARN A and KONING HP, 2015. Potent Trypanocidal Curcumin Analogs Bearing a Mono-enone Linker Motif Act on Trypanosoma Brucei by Forming an Adduct with Trypanothione. Molecular Pharmacology. 87, 451-464 KIM, DH and CREEK, DJ, 2015. What role can metabolomics play in the discovery and development of new medicines for infectious diseases? Bioanalysis. 7(6), 629-631 CREEK, DARREN J, MAZET, MURIEL, ACHCAR, FIONA, ANDERSON, JANA, KIM, DONG-HYUN, KAMOUR, RUWIDA, MORAND, PAULINE, MILLERIOUX, YOANN, BIRAN, MARC, KERKHOVEN, EDUARD J, CHOKKATHUKALAM, ACHUTHANUNNI, WEIDT, STEFAN K, BURGESS, KARL E V, BREITLING, RAINER, WATSON, DAVID G, BRINGAUD, FREDERIC and BARRETT, MICHAEL P, 2015. Probing the Metabolic Network in Bloodstream-Form Trypanosoma brucei Using Untargeted Metabolomics with Stable Isotope Labelled Glucose. PLoS pathogens. 11(3), e1004689 KIM, DONG-HYUN, ACHCAR, FIONA, BREITLING, RAINER and BURGESS, KARL E, 2015. LC–MS-based absolute metabolite quantification: application to metabolic flux measurement in trypanosomes Metabolomics. 11(6), 1721-1732 CHOKKATHUKALAM, ACHUTHANUNNI, KIM, DONG-HYUN, BARRETT, MICHAEL P., BREITLING, RAINER and CREEK, DARREN J., 2014. Stable isotope labeling studies in metabolomics: New insights into structure and dynamics of metabolic networks BIOANALYSIS. 6(4), 511-524 KIM, DONG-HYUN, ALLWOOD, J. WILLIAM, MOORE, ROWAN E., MARSDEN-EDWARDS, EMMA, DUNN, WARWICK B., XU, YUN, HAMPSON, LYNNE, HAMPSON, IAN N. and GOODACRE, ROYSTON, 2014. A metabolomics investigation into the effects of HIV protease inhibitors on HPV16 E6 expressing cervical carcinoma cells MOLECULAR BIOSYSTEMS. 10(3), 398-411 ACHCAR, FIONA, FADDA, ABEER, HAANSTRA, JURGEN R, KERKHOVEN, EDUARD J, KIM, DONG-HYUN, LEROUX, ALEJANDRO E, PAPAMARKOU, THEODORE, ROJAS, FEDERICO, BAKKER, BARBARA M, BARRETT, MICHAEL P, CLAYTON, CHRISTINE, GIROLAMI, MARK, KRAUTH-SIEGEL, R LUISE, MATTHEWS, KEITH R and BREITLING, RAINER, 2014. The silicon trypanosome: a test case of iterative model extension in systems biology. Advances in microbial physiology. 64, 115-43 CREEK, D.J., NIJAGAL, B., KIM, D.-H., ROJAS, F., MATTHEWS, K.R. and BARRETT, M.P., 2013. Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei Antimicrobial Agents and Chemotherapy. 57(6), 2768-2779 KIM D and BARRETT MP, 2013. Metabolite-dependent regulation of gene expression in Trypanosoma brucei. Molecular microbiology. 88(5), 841-5 KIM, DONG-HYUN, JARVIS, ROGER M., ALLWOOD, J. WILLIAM, BATMAN, GAVIN, MOORE, ROWAN E., MARSDEN-EDWARDS, EMMA, HAMPSON, LYNNE, HAMPSON, IAN N. and GOODACRE, ROYSTON, 2010. Raman chemical mapping reveals site of action of HIV protease inhibitors in HPV16 E6 expressing cervical carcinoma cells ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 398(7-8), 3051-3061 KIM, DONG-HYUN, JARVIS, ROGER M., XU, YUN, OLIVER, ANTHONY W., ALLWOOD, J. WILLIAM, HAMPSON, LYNNE, HAMPSON, IAN N. and GOODACRE, ROYSTON, 2010. Combining metabolic fingerprinting and footprinting to understand the phenotypic response of HPV16 E6 expressing cervical carcinoma cells exposed to the HIV anti-viral drug lopinavir ANALYST. 135(6), 1235-1244 LEE, JONG-KI, CHO, JIN-GYEONG, SONG, MYOUNG-CHONG, YOO, JONG-SU, LEE, DAE-YOUNG, YANG, HYE-JOUNG, HAN, KYUNG-MIN, KIM, DONG-HYUN, OH, YOUNG-JUN, JEONG, TAE-SOOK and BAEK, NAM-IN, 2009. Isolation of Isoquinoline Alkaloids from the Tuber of Corydalis turtschaninovii and their Inhibition Activity on Low Density Lipoprotein Oxidation JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY. 52(6), 646-654 LYU, HA-NA, LEE, DAE-YOUNG, KIM, DONG-HYUN, YOO, JONG-SU, LEE, MIN-KYUNG, KIM, IN-HO, BAEK, NAM-IN, 2008. Phenolic compounds from the fruit body of Phenillus linteus increase alkaline phosphatase (ALP) activity of human osteoblast-like cells FOOD SCIENCE AND BIOTECHNOLOGY. 17(6), 1214-1220 YOO, JONG-SU, AHN, EUN-MI, SONG, MYOUNG-CHONG, BANG, MYUN-HO, KIM, DONG-HYUN, HAN, MIN-WOO, KWAK, HO-YOUNG, LEE, DAE-YOUNG, LYU, HA-NA, BAEK, NAM-IN, 2008. Quantitative analysis of coumarins from Angelica gigas using 1H-NMR FOOD SCIENCE AND BIOTECHNOLOGY. 17(3), 573-577 KIM, DONG-HYUN, HAN, KYUNG-MIN, BANG, MYUN-HO, LEE, YOUN-HYUNG, CHUNG, IN-SIK, KIM, DAE-KEUN, KIM, SUNG-HOON, KWON, BYOUNG-MOG, PARK, MI-HYUN and BAEK, NAM-IN, 2007. Cyclohexylethanoids from the flower of Campsis grandiflora BULLETIN OF THE KOREAN CHEMICAL SOCIETY. 28(10), 1851-1853 JUNG SJ, KIM D, HONG Y, LEE J, SONG H, RHO Y and BAEK N, 2007. Flavonoids from the flower of Rhododendron yedoense var. poukhanense and their antioxidant activities. Archives of pharmacal research. 30(2), 146-50 KIM, DONG-HYUN, LEE, JIN-HEE, AHN, EUN-MI, LEE, YOUN-HYUNG, BAEK, NAM-IN and KIM, IN-HO, 2006. Phenolic glycosides isolated from safflower (Carthamus tinctorius L.) seeds increase the alkaline phosphatase (ALP) activity of human osteoblast-like cells FOOD SCIENCE AND BIOTECHNOLOGY. 15(5), 781-785 KIM, DH, HAN, KM, CHUNG, IS, KIM, DK, KIM, SH, KWON, YM, JEONG, TS, PARK, MH, AHN, EM and BAEK, NI, 2005. Triterpenoids from the flower of Campsis grandiflora K. Schum. as human Acyl-Cok cholesterol acyltransferase inhibitors ARCHIVES OF PHARMACAL RESEARCH. 28(5), 550-556 SONG, M. C., KIM, D.-H., HONG, Y. H., YANG, H. J., CHUNG, I. S., KIM, S. H., KWON, B. M., KIM, D. K., PARK, M. H., BAEK, N. I., 2005. Polyacetylenes and sterols from the aerial parts of Chrysanthemum coronarium L. (Garland) FRONTIERS IN NATURAL PRODUCT CHEMISTRY. 1(1), 163-168 KIM D, LEE H, OH Y, KIM M, KIM S, JEONG T and BAEK N, 2005. Iridoid glycosides isolated from Oldenlandia diffusa inhibit LDL-oxidation. Archives of pharmacal research. 28(10), 1156-60 KIM D, JUNG SJ, CHUNG I, LEE Y, KIM D, KIM S, KWON B, JEONG T, PARK M, SEOUNG N and BAEK N, 2005. Ergosterol peroxide from flowers of Erigeron annuus L. as an anti-atherosclerosis agent. Archives of pharmacal research. 28(5), 541-5