Edward began his career with a BSc in Genetics from Leicester University. After working for several years in research labs focussed on medical and human genetics, Ed completed a Master's degree in Bioinformatics, again at Leicester University. After becoming interested in the analysis of large biological datasets during this course, he subsequently moved to Newcastle University to study for a PhD in cancer genomics in Professor Steve Clifford's group, where his project investigated the molecular subclassification of the childhood brain tumour, medulloblastoma, using genetic and epigenetic techniques. After finishing the PhD, he continued working at Newcastle University as a postdoc, where his primary research role involved the continuation of work that arose from his PhD, in addition to offering statistical and bioinformatic support to Professor Clifford's research group, and undertaking collaborative research with investigators based at Nottingham University and Malawi. In October 2013, Ed moved to Northumbria as a Senior Lecturer in Bioinformatics and Biostatistics.

Histologically defined central nervous system primitive neuro-ectodermal tumours (CNS-PNETs) display heterogeneous DNA methylation profiles and show relationships to other paediatric brain tumour types. SCHWALBE, E.C., HAYDEN, J.T., ROGERS, H.A., MILLER, S., LINDSEY, J.C., HILL, R.M., NICHOLSON, S.L., KILDAY, J.P., ADAMOWICZ-BRICE, M., STORER, L., JACQUES, T.S., ROBSON, K., LOWE, J., WILLIAMSON, D., GRUNDY, R.G., BAILEY, S., CLIFFORD, S.C. 2013. Acta Neuropathologica. In press Glycerol and acetaminophen as adjuvant therapy did not affect the outcome of bacterial meningitis in Malawian children. MOLYNEUX, E.M., KAWAZA, K., PHIRI, A., CHIMALIZENI, Y., MANKHAMBO, L., SCHWALBE, E.C., KATAJA, M., PENCILO, P., CHILTON, L., PELTOLA, H., 2013. Paediatric Infectious Diseases Journal. Oct 16 epub. Subgroup-Specific Prognostic Implications of TP53 Mutation in Medulloblastoma. ZHUKOVA, N., RAMASWAMY, V., REMKE, M., PFAFF, E., SHIH, D.J., MARTIN, D.C., CASTELO-BRANCO, P., BASKIN, B., RAY, P.N., BOUFFET, E., VON BUEREN, A.O., JONES, D.T., NORTCHOTT, P.A., KOOL, M., STURM, D., PUGH, T.J., POMEROY, S.L., CHO, Y.J., PIETSCH, T., GESSI, M., RUTKOWSKI, S., BOGNAR, L., KLEKNER, A., CHO, B.K., KIM, S.K., WANG, K.C., EBERHART, C.G., FEVRE-MONTANGE, M., FOULADI, M., FRENCH, P.J., KROS, M., GRAJKOWSKA, W.A., GUPTA, N., WEISS, W.A., HAUSER, P., JABADO, N., JOUVET, A., JUNG, S., KUMABE, T., LACH, B., LEONARD, J.R., RUBIN. J.B., LIAU, L.M., MASSIMI, L., POLLACK, I.F., SHIN RA, Y., VAN MEIR, E.G., ZITTERBART, K., SCHüLLER, U., HILL, R.M., LINDSEY, J.C., SCHWALBE, E.C., BAILEY, S., ELLISON, D.W., HAWKINS, C., MALKIN, D., CLIFFORD, S.C., KORSHUNOV, A., PFISTER, S., TAYLOR, M.D., TABORI, U., 2013. Journal of Clinical Oncology, 31(23), pp. 2927-35. DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsies. SCHWALBE, E.C., WILLIAMSON, D., LINDSEY, J.C., HAMILTON, D., RYAN, S.L., MEGAHED, H., GARAMI, M., HAUSER, P., DEMBOWSKA-BAGINSKA, B., PEREK, D., NORTHCOTT, P.A., TAYLOR, M.D., TAYLOR, R.E., ELLISON, D.W., BAILEY, S., CLIFFORD, S.C., 2013. Acta Neuropathologica, 125(3), pp. 359-71. Treating childhood acute lymphoblastic leukemia in Malawi. CHAGALUKA, G., CAREY, P., BANDA, K., SCHWAB, C., CHILTON, L., SCHWALBE, E., SKINNER, R., ISRAELS, T., MOORMAN, A., MOLYNEUX, E., BAILEY, S., 2013. Haematologica, 98(1), e 1-3. Supratentorial and spinal pediatric ependymomas display a hypermethylated phenotype which includes the loss of tumor suppressor genes involved in the control of cell growth and death. ROGERS, H.A., KILDAY, J.P., MAYNE, C., WARD, J., ADAMOWICZ-BRICE, M., SCHWALBE. E.C., CLIFFORD, S.C., COYLE, B., GRUNDY, R.G., 2012. Acta Neuropathologica, 123(5), pp. 711-25. MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma. RYAN, S.L., SCHWALBE, E.C., Cole, M., LU Y., LUSHER, M.E., MEAGHED, H., O'TOOLE, K., NICHOLSON, S.L., BOGNAR, L., GARAMI, M., HAUSER, P., KORSHUNOV, A., PFISTER, S.M., WILLIAMSON, D., TAYLOR, R.E., ELLISON, D.W., BAILEY, S., CLIFFORD, S.C., 2012. Acta Neuropathologica, 123(4), pp. 501-13. Subtypes of pediatric germ cell tumors share a common DNA methylator signature irrespective of patient age or anatomical location. JEYAPALAN, J.N., MOHAMED, N., LEE, S-H. TAN, C.L., APPLEBY, V.A., KILDAY, J.P., PALMER, R.D., SCHWALBE, E.C., CLIFFORD, S.C., WALKER, D.A., MURRAY, M.J., COLEMAN, N., NICHOLSON, J.C., SCOTTING, P.J., 2011. British Journal of Cancer, 105(4), pp. 575-85. TP53 Mutations in Favorable-Risk Wnt/Wingless-Subtype Medulloblastomas. LINDSEY, J.C., HILL, R.M., MEGAHED, H., LUSHER, M.E., SCHWALBE, E.C., COLE, M., HOGG, T.L., GILBERTSON, R.J., ELLISON, D.W., BAILEY, S., CLIFFORD, S.C., 2011. Journal of Clinical Oncology, 29(12), pp. 344-6. Rapid diagnosis of medulloblastoma subgroups. SCHWALBE, E.C., LINDSEY, J.C., STRAUGHTON, D., HOGG, T.L., COLE, M., MEGAHED, H., RYAN, S.L., LUSHER, M.E., TAYLOR, M.D., GILBERTSON, R.J., ELLISON, D.W., BAILEY, S., CLIFFORD, S.C., 2011. Clinical Cancer Research, 17(7), pp. 1883-94. Genome-wide analysis of alternative splicing in medulloblastoma identifies splicing patterns characteristic of normal cerebellar development. MENGHI, F., JACQUES, T.S., BARENCO M., SCHWALBE, E.C., CLIFFORD, S.C., HUBANK, M., HAM, J., 2011. Cancer Research 71(6), pp. 2045-55.