My most  recent work involves a study of the diastereoselective spiroannulation of phenolic derivatives.

(a) asymmetric synthetic methodology and its application to the synthesis of natural products. (b) isolation, characterization and synthesis of natural products found in medicinal plants used by First Nations of Northern British Columbia, and (c) medicinal chemistry focusing on anti-cancer active compounds

1) Guy L. Plourde, (±)-1-(4-Hydroxy-3-methoxyphenyl)-3-butanol, Molbank 2003, M315. 2) Guy L. Plourde, (±)-7-Methoxy-2-methyl-1-oxaspiro[4,5]deca-6,9-diene-8-one, Molbank2003, M316. 3) Guy L. Plourde, 1-(4-Hydroxy-3-methoxyphenyl)-4-methyl-3-pentanone, Molbank2003, M317. 4) Guy L. Plourde, (±)-1-(4-Hydroxy-3-methoxyphenyl)-4-methyl-3-pentanol, Molbank2003, M318. 5) Guy L. Plourde, (±)-7-Methoxy-2-ipropyl-1-oxaspiro[4,5]deca-6,9-diene-8-one, Molbank 2003, M319. 6) Guy L. Plourde,1-(4-Hydroxy-3-methoxyphenyl)-4,4-dimethyl-3-pentanone,Molbank2003, M320. 7) Guy L. Plourde, (±)-1-(4-Hydroxy-3-methoxyphenyl)-4,4-dimethyl-3-pentanol, Molbank 2003, M321. 8) Guy L. Plourde, (±)-2-tButyl-7-methoxy-1-oxaspiro[4,5]deca-6,9-diene-8-one, Molbank 2003, M322. 9) Guy L. Plourde and Randy R. Spaetzel,Regioselective Protection of the 4-Hydroxyl of 3,4-Dihydroxybenaldehyde, Molecules, 2002, 7, 697-705. 10) G.L. Plourde,Studies towards the diastereoselective spiroannulation of phenolic derivatives, Tetrahedron Letters, 2002 (43) 3597-3599. 11) G.L. Plourde and B.B. Fisher,Synthesis of 6-methoxy-1- oxaspiro[4,5] deca-6,9-diene-8-one, Molecules,2002(7), 315-319. 12) M.A. Bernards, W.D. Fleming, D.B. Llewellyn, R. Priefer, X. Yang, A. Sabatino, G.L. Plourde, Biochemical Characterization of the Suberization-Associated Anionic Peroxidase of Potato (Solanum tuberosum L.), Plant Physiology, 1999 (121), 135-145. 13) G.L. Plourde, R. Priefer, D.B. Llewellyn, Synthesis and Characterization of 1-Hydroxy-2-methoxy-4-(3-propanoic acid) Anthracene, Synthetic Communications, 1999 (29), 2895-2901. 14) E. Piers, N.L. Breau, Y. Han, G.L. Plourde, and W.-L. Yeh,'Total Synthesis of cis Clerodane Diterpenoids: (-)Agelasin A and (+)-(3R,4S,5R,8S,9R,10S)-3,4-Epoxyclerod-13-en-15,16-olide.', J. Chem. Soc., Perkin Trans. I, 1995, 963. 15) Guy L. Plourde and Nadine J. English, Diastereoselective Spiroannulation of Phenolic Substrates: Synthesis of (±)-2-tert-Butyl-6-methoxy-1-oxaspiro[4,5]deca-6,9-diene-8-one, Molecules, 2005 (10), 1335-1339.