Basic Pharmacology

Neurochemicals and receptors in regulation of gut function Role of hemokinin in gut inflammation Interactions between prostaglandins and human enteric nervous system Vanilloid receptors in human bladder: relevance to urge incontinence.

Dai L; King DW; Perera DS; Lubowski DZ; Burcher E; Liu L, 2015, 'Inverse Expression of Prostaglandin E2-Related Enzymes Highlights Differences Between Diverticulitis and Inflammatory Bowel Disease', Digestive Diseases and Sciences, vol. 60, no. 5, pp. 1236 - 1246, http://dx.doi.org/10.1007/s10620-014-3478-7 Diezmos EF; Sandow SL; Perera DS; King DW; Bertrand PP; Liu L, 2015, 'Pannexin-2 is expressed in the human colon with extensive localization in the enteric nervous system', Neurogastroenterology and Motility, http://dx.doi.org/10.1111/nmo.12541 Bertrand PP; Liu L, 2014, 'Explainer: what is inflammatory bowel disease?', The Conversation Bahadory F; Moore KH; Liu L; Burcher E, 2013, 'Gene expression of muscarinic, tachykinin, and purinergic receptors in porcine bladder: Comparison with cultured cells', Frontiers in Pharmacology, vol. 4, no. NOV, pp. 1 - 7, http://dx.doi.org/10.3389/fphar.2013.00148 Wang K; Bertrand RL; Senadheera S; Polglaze KE; Murphy TV; Sandow SL; Bertrand PP; Liu L; Bornstein JC, 2013, 'Motility changes induced by intraluminal FeSO in guinea pig jejunum', Neurogastroenterology and Motility, http://dx.doi.org/10.1111/nmo.12276 Diezmos EF; Sandow SL; Markus I; Shevy Perera D; Lubowski DZ; King DW; Bertrand PP; Liu L, 2013, 'Expression and localization of pannexin-1 hemichannels in human colon in health and disease', Neurogastroenterology and Motility, vol. 25, no. 6, http://dx.doi.org/10.1111/nmo.12130 Dai L; Perera DS; King DW; Southwell BR; Burcher E; Liu L, 2012, 'Hemokinin-1 stimulates prostaglandin E 2 production in human colon through activation of cyclooxygenase-2 and inhibition of 15-hydroxyprostaglandin dehydrogenase', Journal of Pharmacology and Experimental Therapeutics, vol. 340, no. 1, pp. 27 - 36, http://dx.doi.org/10.1124/jpet.111.186155 Sadananda P; Kao FCL; Liu L; Mansfield KJ; Burcher E, 2012, 'Acid and stretch, but not capsaicin, are effective stimuli for ATP release in the porcine bladder mucosa: Are ASIC and TRPV1 receptors involved?', European Journal of Pharmacology, vol. 683, no. 1-3, pp. 252 - 259, http://dx.doi.org/10.1016/j.ejphar.2012.02.041 Bertrand RL; Senadheera S; Tanoto A; Tan KL; Howitt L; Chen H; Murphy TV; Sandow SL; Liu L; Bertrand PP, 2012, 'Serotonin availability in rat colon is reduced during a Western diet model of obesity', American Journal of Physiology: Gastrointestinal and Liver Physiology, vol. 303, no. 3, http://dx.doi.org/10.1152/ajpgi.00048.2012 Liu L; Markus I; Saghire HE; Perera DS; King DW; Burcher E, 2011, 'Distinct differences in tachykinin gene expression in ulcerative colitis, Crohn’s disease and diverticular disease: a role for hemokinin-1?', Neurogastroenterology and Motility, vol. 23, no. 5, pp. 475 - e180, http://dx.doi.org/10.1111/j.1365-2982.2011.01685.x Bertrand RL; Senadheera S; Markus I; Liu L; Howitt L; Chen H; Murphy TV; Sandow SL; Bertrand PP, 2011, 'A western diet increases serotonin availability in rat small intestine', Endocrinology, vol. 152, no. 1, pp. 36 - 47, http://dx.doi.org/10.1210/en.2010-0377 Azriel Y; Liu L; Burcher E, 2011, 'Erratum: Complex actions of neurotensin in ascending and sigmoid colonic muscle: Involvement of enteric mediators (European Journal of Pharmacology (2010) 644 (195-202))', European Journal of Pharmacology, vol. 650, no. 2-3, pp. 708, http://dx.doi.org/10.1016/j.ejphar.2010.10.018 Chadha PS; Liu L; Rikard-Bell M; Senadheera S; Howitt L; Bertrand RL; Grayson TH; Murphy TV; Sandow SL, 2011, 'Endothelium-dependent vasodilation in human mesenteric artery is primarily mediated by myoendothelial gap junctions intermediate conductance calcium-activated K+ channel and nitric oxide', Journal of Pharmacology and Experimental Therapeutics, vol. 336, no. 3, pp. 701 - 708, http://dx.doi.org/10.1124/jpet.110.165795 Harrington AM; Peck CJ; Liu L; Burcher E; Hutson JM; Southwell BR, 2010, 'Localization of muscarinic receptors M1R, M2R and M3R in the human colon', Neurogastroenterology and Motility, vol. 22, no. 9, http://dx.doi.org/10.1111/j.1365-2982.2009.01456.x Azriel Y; Liu L; Bucher E, 2010, 'Complex actions of neurotensin in ascending and sigmoid colonic muscle: Involvement of enteric mediators', European Journal of Pharmacology, vol. 644, no. 1-3, pp. 195 - 202, http://dx.doi.org/10.1016/j.ejphar.2010.06.049 Liu L; Shang F; Morgan MJ; King DW; Lubowski DZ; Burcher E, 2009, 'Cyclooxygenase-dependent alterations in substance P-mediated contractility and tachykinin NK1 receptor expression in the colonic circular muscle of patients with slow transit constipation', Journal of Pharmacology and Experimental Therapeutics, vol. 329, no. 1, pp. 282 - 289, http://dx.doi.org/10.1124/jpet.108.148148 Furlong TM; Vianna DML; Liu L; Carrive P, 2009, 'Hypocretin/orexin contributes to the expression of some but not all forms of stress and arousal', European Journal of Neuroscience, vol. 30, no. 8, pp. 1603 - 1614, http://dx.doi.org/10.1111/j.1460-9568.2009.06952.x Sadananda P; Shang F; Liu L; Mansfield KJ; Burcher E, 2009, 'Release of ATP from rat urinary bladder mucosa: Role of acid, vanilloids and stretch', British Journal of Pharmacology, vol. 158, no. 7, pp. 1655 - 1662, http://dx.doi.org/10.1111/j.1476-5381.2009.00431.x Burcher E; Shang F; Warner FJ; Du Q; Lubowski DZ; King DW; Liu L, 2008, 'Tachykinin NK2 receptor and functional mechanisms in human colon: Changes with indomethacin and in diverticular disease and ulcerative colitis', Journal of Pharmacology and Experimental Therapeutics, vol. 324, no. 1, pp. 170 - 178, http://dx.doi.org/10.1124/jpet.107.130385 Liu L; Mansfield KJ; Kristiana I; Vaux KJ; Millard RJ; Burcher E, 2007, 'The molecular basis of urgency: Regional difference of vanilloid receptor expression in the human urinary bladder', Neurourology and Urodynamics, vol. 26, no. 3, pp. 433 - 438, http://dx.doi.org/10.1002/nau.20326