B.S. Chemistry, 1995, Rivier College, Nashua, NH Ph.D., Biophysics and Biophysical Chemistry, 2002, Johns Hopkins University School of Medicine, Baltimore, MD (Biochemistry, Cellular and Molecular Biology Program, w/ Cynthia Wolberger) Post-Doctoral, 2002-2004, Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, MD (Cancer Research Training Fellow w/ Alexander Wlodawer)

Structural and functional studies of proteins involved in ribosome biogenesis. Biophysical characterization of secreted mycobacterium virulence proteins. Inhibitor design and development. Biophysical and biochemical studies of macromolecules. Determination of protein and nucleic acid structures by X-ray crystallography.

Title: The ancient microbial RIO kinases Author(s): LaRonde, N. A. Source: J Biol Chem Volume: 289 Issue: 14 Pages: 9488-92 Published: 2014 DOI: 10.1074/jbc.R113.538090 / Author-provided URL : added 04-Nov-14 Title: Development of novel molecular probes of the Rio1 atypical protein kinase Author(s): Mielecki, M.; Krawiec, K.; Kiburu, I.; et al. Source: Biochim Biophys Acta Volume: 1834 Issue: 7 Pages: 1292-301 Published: 2013 DOI: 10.1016/j.bbapap.2013.03.012 / Author-provided URL : added 19-Jun-13 Title: ATPase-dependent role of the atypical kinase Rio2 on the evolving pre-40S ribosomal subunit Author(s): Ferreira-Cerca, S.; Sagar, V.; Schäfer, T.; et al. Source: Nat Struct Mol Biol Volume: 19 Issue: 12 Pages: 1316-23 Published: 2012 DOI: 10.1038/nsmb.2403 / Author-provided URL : added 19-Jun-13 Title: Defense systems up: structure of subtype I-C/Dvulg CRISPR/Cas Author(s): Laronde-Leblanc, N. A. Source: Structure Volume: 20 Issue: 9 Pages: 1450-2 Published: 2012 DOI: 10.1016/j.str.2012.08.015 / Author-provided URL : added 19-Jun-13 Title: Structural and biochemical studies of the open state of Lys48-linked diubiquitin Author(s): Lai, M. Y.; Zhang, D.; Laronde-Leblanc, N.; et al. Source: Biochim Biophys Acta Volume: 1823 Issue: 11 Pages: 2046-56 Published: 2012 DOI: 10.1016/j.bbamcr.2012.04.003 / Author-provided URL : added 19-Jun-13 Title: Structural insight into the functional mechanism of Nep1/Emg1 N1-specific pseudouridine methyltransferase in ribosome biogenesis Author(s): Thomas, SR; Keller, CA; Szyk, A; et al. Source: Nucleic Acids Research Volume: 39 Issue: 6 Pages: 2445-2457 Published: MAR 2011 DOI: 10.1093/nar/gkq1131 added 07-Jul-11 Title: BIOL 183 - Kinetic and structural characterization of glutamine-dependent NAD+ synthetase Author(s): Resto, M; LaRonde-LeBlanc, N; Gerratana, B Source: Abstracts of Papers of the American Chemical Society Volume: 238 Pages: 880 Published: AUG 16 2009 added 07-Jul-11 Title: Crystal Structure of Iodotyrosine Deiodinase, a Novel Flavoprotein Responsible for Iodide Salvage in Thyroid Glands Author(s): Thomas, SR; McTamney, PM; Adler, JM; et al. Source: Journal of Biological Chemistry Volume: 284 Issue: 29 Pages: 19659-19667 Published: JUL 17 2009 DOI: 10.1074/jbc.M109.013458 added 07-Jul-11 Title: Regulation of active site coupling in glutamine-dependent NAD(+) synthetase Author(s): LaRonde-LeBlanc, N; Resto, M; Gerratana, B Source: Nature Structural & Molecular Biology Volume: 16 Issue: 4 Pages: 421-429 Published: APR 2009 DOI: 10.1038/nsmb.1567 added 07-Jul-11 Title: Structure and Function of the Macrolide Biosensor Protein, MphR(A), with and without Erythromycin Author(s): Zheng, JT; Sagar, V; Smolinsky, A; et al. Source: Journal of Molecular Biology Volume: 387 Issue: 5 Pages: 1250-1260 Published: APR 17 2009 DOI: 10.1016/j.jmb.2009.02.058