Ph.D. Biochemistry, Weizmann Institute, 1982

Structural Biology, Protein Crystallography.

We are Structural Biologists interested in the relationship between the function and structure of proteins. We use X-ray crystallography to determine the structures of our molecules of interest, and various computational tools to analyze these structures. Functional studies are carried out in our laboratory and/or in collaboration with other investigators. Some of our projects include:

-Structural Genomics (a) Structural Genomics of bacterial proteins of unknown function. (b) The structural consequences of alternative splicing.

-Giardia Drug Targets – structure, function and inhibitor design.

-Function, structure and evolution of the PEP mutase/isocitrate lyase superfamily.

-The pyruvate phosphate dikinase and Enzyme I molecular machines: Spare parts and swiveling domain mechanism.