Antibacterial and antifungal pharmacokinetics & pharmacodynamics; strategies for optimization of antimicrobial therapy and preventing antimicrobial resistance

S. Zelenitsky, E. Rubinstein, H. Iacovides, R. Ariano, A. Kumar. Vancomycin (VAN) Pharmacodynamics (PDs) Predict Survival in Patients with Methicillin-Resistant Staphylococcus aureus (MRSA) Septic Shock. Submitted to 51st ICAAC, Chicago, Il (09/2011) H. Iacovides, A. Forrest, B. Tsuji. In vitro activities of vancomycin and daptomycin in a Staphylococcus aureus cidA mutant. Doctor of Pharmacy Program Research Day, University of Toronto, Toronto ON (05/2010) H. Iacovides, R. Ariano, G. Harding, S. Zelenitsky. Empiric Therapy Using Combinations Prevents the Emergence of Antibiotic-Resistant Enterobacter cloacae in an in vitro Infection Model. 45th ICAAC, Washington, DC (10/2005 H. Iacovides, R. Ariano, G. Harding, S. Zelenitsky. Combination Therapy Preventing the Emergence of Antibiotic-Resistant Enterobacter cloacae. Association of Faculties of Pharmacy of Canada Annual Conference, Saskatoon, SK (06/2005) Zelenitsky S, Iacovides H , Ariano R, Harding GKM. Antibiotic combinations significantly more active than monotherapy in an in vitro infection model of Stenotrophomonas maltophilia. Diagn Microbiol Infect Ds 2005; 51:39-43 Zelenitsky S, Iacovides H, Harding G, Ariano R. Effect of antibiotic sequence on combination regimens against Pseudomonas aeruginosa in a multiple-dose, in vitro infection model. Diagn Microbiol Infect Ds 2004; 49:67-70. Zelenitsky S, Ariano R, Iacovides H, Sun S, Harding G. AUC0-t/MIC is a continuous index of fluoroquinolone exposure and predictive parameter of antibacterial response in an in vitro Streptococcus pneumoniae infection model. J Antimicrob Chemother 2003; 51:905-911