Opportunistic bacteria, Burkholderia cepacia complex. Bacterial pathogenesis and microbial genomics. Antibacterial drug discovery.

Privitkova T, Lightly TJ, Kumar B, Bernier SP, Sorensen JL, Surette MG, Cardona S.T.. 2014. The attenuated virulence of a Burkholderia cenocepacia paaABCDE mutant is due to inhibition of quorum sensing by release of phenylacetic acid. Molecular Microbiology. 94:522-536 Cardona S.T., Selin C, Gislason AS. Genomic tools to profile antibiotic mode of action. Crit Rev Microbiol. 2014 Mar 12. [Epub ahead of print] PubMed PMID: 24617440. Bloodworth, R. A. M., Gislason, A, Cardona, S.T. 2013. A Burkholderia cenocepacia Conditional Growth Mutant Library created by Random Promoter Replacement of Essential Genes. Microbiology Open 2:243-258. Kaplan, J., LoVetri, K., Cardona, S.T. , Madhyastha, S., Sadovskaya, I., Jabbouri, S., and Izano, E. 2012. Antibiofilm activity of recombinant human DNase I (Pulmozyme?) against Staphylococcus aureus and Staphylococcus epidermidis. The Journal of Antibiotics. 65:73-77. Imolhore I.A.I., Cardona, S.T., 2011. Three-hydroxyphenylacetic acid induces the Burkholderia cenocepacia phenylacetic acid degradation pathway - Towards understanding the contribution of aromatic catabolism. Frontiers in Cellular and Infection Microbiology 1. Yakandawala, N., Gawande, P., LoVetri, K., Cardona, S.T., Romeo, T., Nitz, M. and Madhyastha, S. 2011. Characterization of Poly-?-1, 6-N-Acetylglucosamine Polysaccharide Component of Burkholderia Biofilms. Applied and Environmental Microbiology 77:8303-8309. Yudistira, H., McClarty, L., Hammond, S., Butcher, H., Mark, B. L. and Cardona S. T. 2011. Phenylalanine Induces Burkholderia cenocepacia Phenylacetic Acid Catabolism Through Degradation To Phenylacetyl-CoA In Synthetic Cystic Fibrosis Sputum Medium. Microbial Pathogenesis 52:183-193. Hamlin, J.N., Bloodworth, R.A.M., and Cardona, S.T. 2009. Regulation of phenylacetic acid degradation genes of Burkholderia cenocepacia K56-2. BMC Microbiology 8:222. Law, R. J., Hamlin, J. N., Sivro, A., McCorrister, S. J., Cardama, G. A., and Cardona, S. T. 2008. A functional phenylacetic acid catabolic pathway is required for full pathogenicity of Burkholderia cenocepacia in the Caenorhabditis elegans host model. Journal of Bacteriology 190: 7209-7218. Ortega, X. P., Cardona, S. T., Brown A. R., Loutet, S. A., Flannagan, R. S., Campoiano, D. J., Govan, J. R. W., and Valvano, M. A. 2007. A lipopolysaccharide modification gene cluster essential for viability in Burkholderia cenocepacia. Journal of Bacteriology 189:3639-3644. Cardona, S. T., Mueller C., and Valvano, M. A. 2006. Identification of essential operons in Burkholderia cenocepacia with a rhamnose inducible promoter. Applied and Environmental Microbiology 72:2547-2555.