2005-2009 Doctor of Philosophy Pharmaceutical technology, drug delivery and nanotechnology Laboratory of Pharmaceutical Technology Department of Pharmacy University of Patras, Greece 2000-2005 Bachelor of Science in Chemical Engineering Speciality: Biotechnology School of Chemical Engineering National Technical University of Athens, Greece

Berman M, Mattheolabakis G, Suresh M, Amiji M, Reversing epigenetic mechanisms of drug resistance in solid tumors using targeted microRNA delivery, (Expert Opin Drug Deliv. 2016 Apr 29:1-12) Ryo Hotta, Lily Cheng, Hannah K. Graham, Nandor Nagy, Jaime Belkind-Gerson, George Mattheolabakis, Mansoor M. Amiji, and Allan M. Goldstein, Delivery of enteric neural progenitors with 5-HT4 agonist-loaded nanoparticles and thermosensitive hydrogel enhances cell proliferation and differentiation following transplantation in vivo (Biomaterials, 2016 May; 88:1-11) Amit Singh, Jing Xu, George Mattheolabakis, and Mansoor Amiji, Redox-Responsive EGFR-Targeted Gelatin Nanoparticles for Combination wt-p53 Plasmid DNA and Gemcitabine Treatment in Pancreatic Cancer Cells, (Nanomedicine. 2015 Dec 3. pii: S1549-9634(15)00217-8. doi: 10.1016/j.nano.2015.11.010) Lara Milane, Amit Singh, George Mattheolabakis, Megha Suresh, and Mansoor M. Amiji,Exosome Mediated Communication within the tumor microenvironment,J Control Release. 2015 Jul 1. pii: S0168-3659(15)30001-8. doi: 10.1016/j.jconrel.2015.06.029 George Mattheolabakis, Lara Milane, Amit Singh, Mansoor Amiji, Hyaluronic Acid Targeting of CD44 for Cancer Therapy: From Receptor Biology to Nanomedicine, (Invited review for Special Issue in honor of dr. Langer. J Drug Target, 2015; 23(7–8): 605–618) Huyen Tran, George Mattheolabakis, Hibah Aldawsari, and Mansoor Amiji. Exosomes as Nanocarriers for Immunotherapy of Cancer and Inflammatory diseases, (Clin Immunol. 2015 Apr 2, pii: S1521-6616(15)00124-2. doi: 10.1016/j.clim.2015.03.021) George Mattheolabakis, Ioannis Papayannis, Jennifer Yang, Brandon M. Vaeth, Ruixue Wang, Nengtai Ouyang, Basil Rigas and Gerardo G. Mackenzie, Phospho-aspirin (MDC-22) prevents pancreatic carcinogenesis in mice, (Cancer Prev Res(Phila). 2016 Jul; 9(7):624-34) Lauren E. Bartels, George Mattheolabakis, Joseph F. LaComb, Brandon M Vaeth1, Jizu Zhi, Basil Rigas and Gerardo G. Mackenzie, The novel agent phospho-glycerol-ibuprofen-amide (MDC-330) inhibits glioblastoma growth in mice: An effect mediated by cyclin D1, (Carcinogenesis. 2016 Apr; 37(4):420-9) Wong, Chi; Cheng, Ka Wing; Papayannis, Ioannis; George Mattheolabakis; Huang, Liqun; Xie, Gang; Ouyang, Nengtai; Rigas, Basil, Phospho-NSAIDs have enhanced efficacy in mice lacking plasma carboxylesterase: Implications for their clinical pharmacology, (Pharm Res. 2014 Nov 13) George Mattheolabakis, Chi C Wong, Yu Sun, Carol A Amella, Robert Richards, Panayiotis P. Constantinides, Basil Rigas, Pegylation improves the pharmacokinetics and bioavailability of small-molecule drugs hydrolysable by esterases: A study of phospho-ibuprofen, (Journal of Pharmacology and Experimental Therapeutics, jpet.114.217208; published ahead of print July 21, 2014, doi:10.1124/jpet.114.217208) Ka Wing Cheng, Ting Nie, Nengtai Ouyanga, Ninche Alston, Chi C. Wong, George Mattheolabakis, Ioannis Papayannis, Liqun Huang, Basil Rigas. A novel ibuprofen derivative with anti-lung cancer properties: Synthesis, formulation, pharmacokinetic and efficacy studies, (International Journal of Pharmaceutics, Oct 2014, doi:10.1016/j.ijpharm.2014.10.019) Gerardo G. Mackenzie, Liqun Huang, Ninche Alston, Nengtai Ouyang, Kvetoslava Vrankova, George Mattheolabakis, Panayiotis P. Constantinides, Basil Rigas, Targeting Mitochondrial STAT3 with the Novel Phospho-Valproic Acid (MDC-1112) Inhibits Pancreatic Cancer Growth in Mice, (PLOS ONE, May 2013, Volume 8, Issue 5, e61532) Ka-Wing Cheng , Chi C. Wong , George Mattheolabakis , Gang Xie, Liqun Huang and Basil Rigas, Curcumin enhances the lung cancer chemopreventive efficacy of phospho-sulindac by improving its pharmacokinetics, (Int J Oncol. 2013 Sep;43(3):895-902. doi: 10.3892/ijo.2013.1995. Epub 2013 Jun 27.) George Mattheolabakis, Gerardo G. Mackenzie, Liqun Huang, Nengtai Ouyang, Ka Wing Cheng, Basil Rigas, Topically applied phospho-sulindac hydrogel is efficacious and safe in the treatment of experimental arthritis in rats, (Pharmaceutical Research, March 2013, DOI 10.1007/s11095-012-0953-8) George Mattheolabakis, Basil Rigas and Panayiotis P. Constantinides, Nanodelivery Strategies in Cancer Chemotherapy: Biological Rationale and Pharmaceutical Perspectives, (Nanomedicine, 2012 Oct; 7(10):1577-90) George E. Magoulas, Thomas Garnelis, Constantinos M. Athanassopoulos, Dionissios Papaioannou, George Mattheolabakis, Konstantinos Avgoustakis, Dimitra Hadjipavlou-Litinac, Synthesis and antioxidative/anti-inflammatory activity of novel fullerene–polyamine conjugates, (Tetrahedron, 68, 35, 2 September 2012, 7041–7049) Ka Wing Cheng, George Mattheolabakis, C. C. Wong, Nengtai Ouyang, Liqun Huang, Panayiotis P. Constantinides and Basil Rigas, Topical phospho-sulindac (OXT-328) is effective in the treatment of non-melanoma skin cancer, (International Journal of Oncology, 2012 Jul 27, DOI: 10.3892/ijo.2012.1577) Spiridoula Kyriakopoulou, George Mattheolabakis, Sofia Papadimitriou, Evangelos Karavas, Dimitrios Bikiaris and Konstantinos Avgoustakis, PPSu-PEG Copolymers and their Application in the Preparation of Cisplatin-loaded Nanoparticles, (Current nanoscience, 2011, 7, 4, 503-509) George Mattheolabakis, Ting Nie, Panayiotis P. Constantinides, Basil Rigas, Sterically stabilized liposomes incorporating the novel anticancer agent phospho-ibuprofen (MDC-917): Preparation, characterization and in vitro/in vivo evaluation, (Pharmaceutical Research, 2011, DOI: 10.1007/s11095-011-0619-y) Zacharoula Iatridi, George Mattheolabakis, Konstantinos Avgoustakis, and Constantinos Tsitsilianisa, Self-assembly and drug delivery studies of pH/thermo-sensitive polyampholytic (A-co-B)-b-C-b-(A-co-B) segmented terpolymers, (Soft matter, 2011, 7, 23, 11160-11168) Alexandros A. Vassiliou, Sofia A. Papadimitriou, Dimitrios N. Bikiaris, George Mattheolabakis, Konstantinos Avgoustakis, Facile synthesis of polyester-PEG triblock copolymers and preparation of amphiphilic nanoparticles as drug carriers, (Journal of Controlled Release, 148-3, 2010, 388-395) Bakandritsos A., GeorgeMattheolabakis, Chatzikyriakos G., Szabo T., Tzitzios V., Kouzoudis D., Couris S., Konstantinos Avgoustakis, Doxorubicin Nanocarriers Based on Magnetic Colloids with a Bio-polyelectrolyte Corona and High Non-linear Optical Response: Synthesis, Characterization, and Properties, (Advanced Functional Materials, 2011, 21, 8, 1465-1475) Blatsios G., Tzimas A., GeorgeMattheolabakis, Panagi Z., Avgoustakis K., Gartaganis S., Development of biodegradable controlled release sclera systems of Triamcinolone acetonide, (Current Eye Research, 2010, 35, 10, 916-924.) Bakandritsos A., GeorgeMattheolabakis, Zboril R.,Bouropoulos N., Tucek J., Fatouros D., Avgoustakis K., Preparation, stability and cytocompatibility of magnetic/PLA-PEG hybrids, (Nanoscale, 2010, 2, 564–572) George Mattheolabakis, Lagoumintzis G., Panagi Z.,Papadimitriou E., Partidos C. D., Avgoustakis K., Transcutaneous Delivery of a Nanoencapsulated Antigen: Induction of Immune Responses, (Intern. J. of Pharm. 385, 2010, 187–193)