Hill, Ronald 照片

Hill, Ronald

Associate Professor

所属大学: University of Louisian at Monroe

所属学院: Department of Basic Pharmaceutical Sciences

邮箱:
rhill@ulm.edu

个人主页:
http://www.ulm.edu/pharmacy/bps/hill.html

个人简介

1991 Ph.D., Pharmacy (Medicinal Chemistry) The Ohio State University Columbus, OH 1982 B.S., Chemistry University of Michigan Ann Arbor, MI

近期论文

Satyanarayanajois, S.D., Hill, R.A. (2011). Medicinal chemistry for 2020. Future Med. Chem. 14: 1765-1786 Johnson, Wilbur, Jr.; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel C.; Marks, James G., Jr.; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; et al. Amended safety assessment of Sesamum indicum (sesame) seed oil, hydrogenated sesame seed oil, Sesamum indicum (sesame) oil unsaponifiables, and sodium sesameseedate. International Journal of Toxicology (2011), 30(Suppl. 1), 40S-53S. [and 4 other similar publications from the same group so far in 2011] Becker, Lillian C.; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel C.; Marks, James G., Jr.; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; et al. Amended safety assessment of dodecylbenzenesulfonate, decylbenzenesulfonate, and tridecylbenzenesulfonate salts as used in cosmetics. International Journal of Toxicology (2010), 29(Suppl. 4), 288S-305S. [and 6 other similar publications from the same group in 2010] Khanfar MK, Hill RA, Kaddoumi A, El Sayed KA.* 2010. Combined ligand and structure-based virtual screening for identification of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability. J Med. Chem. 53(24), 8534-8545 Hill, Ronald A. Chapter 20: Hormone-Related Disorders–Nonsteroidal Therapies. In: Wilson and Gisvold’s Textbook of Organic Medicinal and Pharmaceutical Chemistry, 12th edit. John H. Block, John M. Beale, Jr., Eds., 2010. Zharikova, O. L.; Fokina, V. M.; Nanovskaya, T. N.; Hill, R. A.; Mattison, D. R.; Hankins, G. D. V.; Ahmed, M. S.* Identification of the major human hepatic and placental enzymes responsible for the metabolism of glyburide. Biochemical Pharmacology, 2009, 78(12), 1483-1490. Devarakonda, B.; Otto, D. P.; Judefeind, A.; Hill, R. A.; de Villiers, M. M.* Effect of pH on the solubility and release of furosemide from polyamidoamine (PAMAM) dendrimer complexes. International Journal of Pharmaceutics, 2007, 345, 142–153. Zharikova, O. L.; Ravindran, S.; Nanovskaya, T. N.; Hill, R. A.; Hankins, Gary D. V.; Ahmed, M. S.* Kinetics of glyburide metabolism by hepatic and placental microsomes of human and baboon. Biochemical Pharmacology 2007, 73, 2012–2019. Schulte, Marvin K.;* Hill, Ronald A.;* Bikádi, Zsolt;* Maksay, Gábor; Parihar, Harish S.; Joshi, Prasad; Suryanarayanan, Asha. The structural basis of ligand interactions in the 5-HT3 receptor binding site. In Biological and Biophysical Aspects of Ligand-Gated Ion Channel Receptor Superfamilies. Arias, Hugo R., editor. (Research Signpost Press, 2006, ISBN 81-7736-254-2), pp 127–154. Chilakapati, J., Korrapati, M.C., Hill, R.A., Warbritton, A., Latendresse, J.R., and Mehendale, H.M. Role of thioacetamide sulfoxide in saturation of toxicokinetics of thioacetamide. Toxicology 2007, 230, 105-116 Chilakapati, J., Korrapati, M.C., Shankar, K., Hill, R.A., Warbritton, A., Latendresse, J.R.and Mehendale, H.M. Role of CYP2E1 and saturation kinetics in the bioactivation of thioacetamide: effects of diet restriction and phenobarbital. Toxicol. Appl. Pharmacol. 2007, 219, 72-84 Selvan, R.; Zharikova, O. L.; Hill, R. A.; Nanovskaya, T. N.; Hankins, G. D. V.; Ahmed, M. S.* Identification of Glyburide Metabolites formed by Hepatic and Placental Microsomes of Humans and Baboons. Biochemical Pharmacology 2006, 72(12), 1730-1737. Devarakonda, B.; Hill, R. A.; Liebenberg, W.; Brits, M.; De Villiers, M. M.* Comparison of the aqueous solubilization of practically insoluble niclosamide by polyamidoamine (PAMAM) dendrimers and cyclodextrins. International Journal of Pharmaceutics, 2005, 304, 193–209 Chilikapati, J.; Shankar, K.; Korrapati, M. C.; Hill, R. A.; Mehendale, H. M.* Saturation Toxicokinetics of Thioacetamide: Role in Development of Liver Injury. Drug Metab. Dispos., 2005, 33, 1877–1885. Liu, D. L.; Hill, R. A.* Treatment of Certain ortho-Substituted Benzaldehydes with Nitronium Tetrafluoroborate in Acetonitrile Yields Nitrated a,a-Bisacetamido Toluenes. J. Org. Chem., in revision. Devarakonda, B.; Hill, R. A.; de Villiers, M. M.* The Effect of PAMAM Dendrimer Generation Size and Surface Functional Group on the Aqueous Solubility of Nifedipine. Int. J. Pharm., 2004, 284(1–2), 133–140 Hill, R. A.* Rudra, S.; Peng, B.; Roane, D. S.; Bounds, J. K.; Zhang, Y.; Adloo, A. A; Lu, T. Hydroxyl-Substituted Sulfonylureas as Potent Inhibitors of Specific [3H]Glyburide Binding to Rat Brain Synaptosomes. Bioorg. Med. Chem., 2003, 11, 2099-2113. Goskonda, V. R.; Hill, R. A.; Khan, M. A.; Reddy, I. K.* Permeability of Chemical Delivery Systems Across Rabbit Corneal (SIRC) Cell Line and Isolated Corneas: A Comparative Study. Pharm. Dev. Technol. 2000, 5, 409–416. Wu, J.; Barrois, M. J.; Zhou, L. H.; Ace, L. N., Jr.;* Liu, D. L.; Danthi, S. N.; Hill, L. J.; Hill, R. A.* Potential Prodrugs of a Triply-Ionized a-Amino Acid AMPA Antagonist: Biotransformation in Rat Brain Homogenates and Preliminary In Vivo Studies. In active preparation for J. Pharm. Sci.; partial abstract published: AAPS PharmSci. 1999, 4, S515.) Bhat, A.; Chang, H.-M.; Wallace, L. J.; Weinstein, D. M.; Shams, G.; Garris, C. C.; Hill, R. A.* 1,4-Dihydro-2,3-quinoxalinediones as Potential Flavin Metabolites and Excitatory Amino Acid Receptor Ligands. I. Synthesis and Pharmacological Evaluation of the Benzylic Oxidation Series of 1,4-Dihydro-6,7-dimethyl-2,3-quinoxalinedione. Bioorg. Med. Chem.1998, 6, 271–282. Danthi, S. N.; Hill, R. A.* Synthesis of chirally pure 2,5-disubstituted diketopiperazines derived from trisubstituted phenylalanines. J. Heterocycl. Chem. 1997, 34, 835–844. Hill, R. A.; Wallace, L. J.; Miller, D. D.*; Tai, H.; Layer, R. T.; Weinstein, D.; Willins, D. L.; Uretsky, N. J. Structure-activity Studies for a-Amino-3-hydroxy-5-methyl-4-isoxazolepropanoic Acid Receptors: Acidic Hydroxyphenylalanines. J. Med. Chem. 1997, 40, 3182–3191. Yamreudeewong, W.*; Danthi, S. N.; Hill, R. A.* Stability of Ondansetron for Injection Admixtures with Various Beverages for Oral Administration. Am. J. Health-Syst. Pharm. 1995, 52, 2011–2014. Hill, R. A.; Labanowski, J. K.*; Heisterberg, D. J.; Miller, D. D.* Formic Acid: Methylamine Complex Studied by the Hartree-Fock and Density Functional Approaches. In Density Functional Methods in Chemistry (Springer-Verlag: New York, 1991) pp. 357–372. Ronald A. Hill. Part 1. Design, Synthesis, and Structure-Activity Studies of Molecules with Activity at Non-NMDA Glutamate Receptors: Hydroxyphenylalanines, Quinoxalinediones and Related Molecules. Part 2. Computational Studies on the Interaction of the Dopamine Amino Group and Amino Group Replacements with Carboxylate Anions as a Model for Receptor Interactions. Ph.D. Dissertation, The Ohio State University, Columbus, Ohio, 1991.