Cellular processes involved in the detection, repair or tolerance of DNA damage; mechanisms of mutation induction and carcinogenesis, cell cycle control; development of methods for DNA damage detection and human biomonitoring.

Disruption Elevates Diadenosine Tetraphosphate (Ap(4)A) and Down-Regulates Immune Response and Cancer Promotion Genes. Diadenosine 5 ', 5 '''-P-1,P-4-tetraphosphate (Ap(4)A) is synthesized in response to DNA damage and inhibits the initiation of DNA replication. The Fanconi Anemia Proteins FANCD2 and FANCJ Interact and Regulate Each Other's Chromatin Localization. Functional and physical interaction between the mismatch repair and FA-BRCA pathways. Statistical Association of Basal Cell Keratins with Metastasis-Inducing Proteins in a Prognostically Unfavorable Group of Sporadic Breast Cancers. Several tetratricopeptide repeat (TPR) motifs of FANCG are required for assembly of the BRCA2/D1-D2-G-X3 complex, FANCD2 monoubiquitylation and phleomycin resistance. Significance of the Fanconi Anemia FANCD2 Protein in Sporadic and Metastatic Human Breast Cancer. Stabilizing and Remodeling the Blocked DNA Replication Fork: Anchoring FANCM and the Fanconi Anemia Damage Response.