Chemical Biology

A new pseudomonas quinolone signal (PQS) binding partner: MexG, J. T. Hodgkinson, J. Gross, Y.R. Baker, D.R. Spring, M. Welch, Chem. Sci. 2016, 7, 2553. The synthesis of Quinolone Natural Products from Pseudonocardia sp. F. Salvaggio, J. T. Hodgkinson, L. Carro, S.M. Geddis, W.R.J.D. Galloway, M. Welch, D.R. Spring, Eur. J. Org. Chem. 2016, 3, 434-437 Combating multi-drug resistant bacteria: current strategies for the discovery of novel antibacterials, K. M. G. O'Connell, J. T. Hodgkinson, H. F. Sore, M. Welch, G. P. C. Salmond, D. R. Spring, Angew. Chem. Int. Ed. 2013, 52, 10706-10733. Preparation of the quorum sensing molecule 2-heptyl-3-hydroxy-4(1H)-quinolone (Pseudomonas quinolone signal or PQS) and structurally related analogues with biological activity using a microwave-assisted procedure, J. T. Hodgkinson, W. R. J. D. Galloway, M. Welch, D. R. Spring, Nature Protoc. 2012, 7, 1184-1192. Design, synthesis and biological evaluation of non-natural modulators of quorum sensing in Pseudomonas aeruginosa, J. T. Hodgkinson, W. R. J. D. Galloway, M. Wright, I. K. Mati, R. L. Nicholson, M. Welch, D. R. Spring, Org. Biomol. Chem. 2012, 10, 6032-6044. Microwave and flow syntheses of Pseudomonas quinolone signal (PQS) and analogues, J. T. Hodgkinson, W. R. J. D. Galloway, S. Saraf, I. R. Baxendale, S. V. Ley, M. Ladlow, M. Welch, D. R. Spring, Org. Biomol. Chem. 2011, 9, 57-61. Structure-Activity Analysis of the Pseudomonas Quinolone Signal Molecule, J. T. Hodgkinson, S. D. Bowden, W. R. J. D. Galloway, D. R. Spring, M. Welch, J. Bacteriol. 2010, 192, 3833-3837.