PhD with Dr Fred Sanger: MRC Laboratory of Molecular Biology, Cambridge University, 1981. SERC-NATO post-doctoral fellow with Joan Steitz, Yale University, USA, 1982 and 1983. Joined staff of Department of Biochemistry in 1984. Appointed Reader in Biochemistry from 1994. Awarded a Personal Chair in Biochemistry, 2000.

Single molecule studies on the molecular mechanisms of mammalian pre-mRNA splicing, splice site selection and the regulation of alternative splicing Using our understanding of these processes to develop potential therapies for diseases