Chang-Guo Zhan received a Ph.D. in Chemistry from University of Notre Dame and a Ph.D. in Science (Molecular Physics) from Institute for Molecular Science (IMS), Japan (Graduate University of Advanced Studies). Dr. Chang-Guo Zhan performed his postdoctoral research as a Postdoctoral Research Scientist at Department of Medicine, Columbia University. After that, he served as Associate Research Scientist at Department of Medicine, Columbia University and a Visiting Scientist at Pacific Northwest National Laboratory at the same time. Dr. Zhan joined the UK College of Pharmacy faculty as Associate Professor on July 1st, 2003 and was promoted to Professor on July 1st, 2007. He was elected the Fellow of American Association of Pharmaceutical Scientists (AAPS) in 2010, and received 2016 AAPS Research Achievement Award in Drug Discovery and Development Interface. Dr. Zhan was named "University Research Professor" by the University President and Board of Trustee in May 2016.

Development of reliable and efficient tools for drug design, discovery, and development Integrated in silico, in vitro, and in vivo approaches to drug discovery and development Protein engineering and development of therapeutic enzymes Rational design, discovery, and development of novel therapeutic agents that may be small-molecules, peptides, or proteins Translational research - from discovery to therapy

Chen X, Xue L, Hou S, Jin Z, Zhang T, Zheng F, Zhan C-G. (2016). Long-acting cocaine hydrolase for addiction therapy. Proc. Natl. Acad. Sci. USA, 113, 422-427. Quizon PM, Sun WL, Yuan Y, Midde N M, Zhan C-G, Zhu J. (2016). Molecular mechanism: the human dopamine transporter histidine 547 regulates basal and HIV-1 Tat protein-inhibited dopamine transport. Sci. Rep., 6, 39048. doi: 10.1038/srep39048. Yuan Y, Quizon PM, Sun WL, Yao J, Zhu J, Zhan C-G. (2016). Role of Histidine 547 of Human Dopamine Transporter in Molecular Interaction with HIV-1 Tat and Dopamine Uptake. Sci. Rep., 6, 27314. doi: 10.1038/srep27314. Yao J, Yuan Y, Zheng F, Zhan C-G. (2016). Unexpected reaction pathway for butyrylcholinesterase-catalyzed inactivation of "hunger hormone" ghrelin. Sci. Rep., 6, 22322. doi: 10.1038/srep22322. Zhang C, Pu J, Yang X, Feng T, Liu F, Wang D, Xu X, Gao A, Liu H, Zhan C-G, Liao F. (2016). Extracorporeal delivery of a therapeutic enzyme. Sci. Rep., 6, 30888. doi: 10.1038/srep30888. Chen X, Zheng X, Zhan M, Zhou Z-Y, Zhan C-G, Zheng F. (2016). Metabolic enzymes of cocaine metabolite benzoylecgonine. ACS Chem. Biol., 11, 2186-2194. Yuan Y, Huang X, Midde N M, Quizon P M, Sun W L, Zhu J, Zhan C-G. (2015). Molecular mechanism of HIV-1 Tat interacting with human dopamine transporter. ACS Chem. Neurosci., 6, 658-665. Research Highlight – “Viral Mechanisms: Tat modulates DAT”, Nature Chem. Biol. 2015, 11, 240. Miller Z, Kim K S, Lee D M, Kasam V, Baek S E, Lee K H, Zhang Y Y, Ao L, Carmony K, Lee N R, Zhou S, Zhao Q, Jang Y, Jeong H Y, Zhan C -G, Lee W, Kim D E, Kim K B. (2015). Proteasome inhibitors with pyrazole scaffolds from structure-based virtual screening. J. Med. Chem., 58, 2016-2341. Zheng F, Xue L, Hou S, Liu J, Zhan M, Yang W, Zhan C-G. (2014). A highly efficient cocaine-detoxifying enzyme obtained by computational design. Nature Commun., 5, 3457. Burikhanov R, Sviripa V M, Hebbar N, Zhang W, Layton W J, Hamza A, Zhan C-G, Watt D S, Liu C, Rangnekar V M. (2014). Arylquin-1 targets vimentin to trigger Par-4 secretion for tumor cell apoptosis. Nature Chem. Biol., 10, 924-926.