Ongoing research in the Fritzsch laboratory focuses on four main themes:

Molecular basis of ear development (currently funded by NIH/NIDCD R01) Molecular basis of inner ear efferent and brainstem motoneuron formation (currently funded as a subcontract of an NIH R01 with Children's Hospital, Boston) Molecular basis of hair cell proliferation, maintenance and regeneration Improving multicolor dye tracing techniques (currently funded by NIH/NIMH SBIR II)

Cell and Developmental Biology, Evolution, Genetics, Neurobiology

Glasco D.M., Pike W., Qu Y., Reustle L., Misra K., Di Bonito M., Studer M., Fritzsch B., Goffinet A.M., Tissir F., Chandrasekhar A. 2016. The atypical cadherin Celsr1 functions non-cell autonomously to block rostral migration of facial branchiomotor neurons in mice. Developmental Biology. 417: 40-49. Fritzsch B., Duncan J.S., Kersigo J., Gray B., Elliott K.L. 2016. Neuroanatomical Tracing Techniques in the Ear: History, State of the Art, and Future Developments. Auditory and Vestibular Research: Methods and Protocols. 1427: 243-262. Yuhki Saito, Soledad Miranda-Rottmann, Matteo Ruggiu, Christopher Y Park, John J Fak, Ru Zhong, Jeremy S Duncan, Brian A Fabella, Harald J Junge, Zhe Chen, Roberto Araya, Bernd Fritzsch, AJ Hudspeth, Robert B Darnell. 2016. NOVA2-mediated RNA regulation is required for axonal pathfinding during development. eLife. 5: e14371. Tetyana Chumak, Romana Bohuslavova, Iva Macova, Nicole Dodd, Daniela Buckiova, Bernd Fritzsch, Josef Syka, Gabriela Pavlinkova. 2016. Deterioration of the medial olivocochlear efferent system accelerates age-related hearing loss in Pax2-Isl1 transgenic mice. Mol Neurobiol. 53: 2368-2383. Romana Bohuslavova, Nicole Dodd, Iva Macova, Tetyana Chumak, Martin Horak, Josef Syka, Bernd Fritzsch, Gabriela Pavlinkova. 2016. Pax2-Islet1 Transgenic Mice Are Hyperactive and Have Altered Cerebellar Foliation. Mol Neurobiol. :1-17. Tian Yang, Elizabeth S Scholl, Ning Pan, Bernd Fritzsch, Françoise Haeseleer, Amy Lee. 2016. Expression and Localization of CaBP Ca 2+ Binding Proteins in the Mouse Cochlea. PloS one. 11: e0147495. YY Szeto, KH Chu, YK Au, YH Huang, S Wynn, A Mak, YS Chan, R Lovell-Badge, WY Chan, R Jauch, B Fritzsch, MH Sham, KSE Cheah. 2016. The SOX9Y440X campomelic dysplasia mutation disrupts endolymph homeostasis. Gordon Research Conference: Fibroblast Growth Factors in Development & Disease. The Chinese University of Hong Kong, Hong Kong, China. Alain Dabdoub, Bernd Fritzsch, Arthur N Popper, Richard R Fay. 2016. The primary auditory neurons of the Mammalian Cochlea: with 58 illustrations. Springer handbook of auditory research. 52. Alain Dabdoub, Bernd Fritzsch. 2016. Connecting the Inner Ear to the Central Auditory System: Molecular Development and Characteristics of the Primary Auditory Neurons and Their Network. The Primary Auditory Neurons of the Mammalian Cochlea. Springer handbook of auditory research. 52:1-10. Bernd Fritzsch, Jennifer Kersigo, Tian Yang, Israt Jahan, Ning Pan. 2016. Neurotrophic Factor Function During Ear Development: Expression Changes Define Critical Phases for Neuronal Viability. The Primary Auditory Neurons of the Mammalian Cochlea. Springer handbook of auditory research. 52:49-84.