Scott E. Denmark was born in Lynbrook, NY in 1953. He obtained a S. B. from the Massachusetts Institute of Technology in 1975 and a D.Sc. Tech. from the ETH-Zürich under the direction of Albert Eschenmoser in 1980. That same year he was appointed as assistant professor at the University of Illinois and since 1991 has been the Reynold C. Fuson Professor of Chemistry. Professor Denmark has won a number of honors including the Pedler and Robert Robinson Medals (RSC), the Aldrich Award for Creative Work in Synthetic Organic Chemistry, Brown Award for Creative Research in Synthetic Methods, the F. S. Kipping Award in Silicon Chemistry (ACS), the Prelog Medal, Noyori Prize and the Paracelsus Prize. He is currently on the Board of Directors of Organic Reactions and Organic Syntheses and serves on the Editorial Advisory Boards of the Journal of the American Chemical Society, the Journal of Organic Chemistry and Organic Letters.

synthetic organic chemistry; invention of new organic reactions (organoelement chemistry); elucidation of structure-reactivity-selectivity relationships (mechanistic studies); total synthesis of natural products (alkaloids, polypropionates, polyenes, C-aryl glycosides)

Catalytic allylation of native hexoses and pentoses in water with indium Adak, T., Menard, T., Albritton, M., Florit, F., Burke, M., Jensen, K. F. & Denmark, S. E., Apr 3 2025, In: Nature. 640, 8057, p. 94-99 6 p. Chemoinformatic Catalyst Selection Methods for the Optimization of Copper-Bis(oxazoline)-Mediated, Asymmetric, Vinylogous Mukaiyama Aldol Reactions Olen, C. L., Zahrt, A. F., Reilly, S. W., Schultz, D., Emerson, K., Candito, D., Wang, X., Strotman, N. A. & Denmark, S. E., Feb 16 2024, In: ACS Catalysis. 14, 4, p. 2642-2655 14 p. ChemScraper: leveraging PDF graphics instructions for molecular diagram parsing Shah, A. K., Amador, B., Dey, A., Creekmore, M., Ocampo, B., Denmark, S. & Zanibbi, R., Sep 2024, In: International Journal on Document Analysis and Recognition. 27, 3, p. 395-414 20 p. Effects of Ring Size and Steric Encumbrance on Boron-to-Palladium Transmetalation from Arylboronic Esters Delaney, C. P., Zahrt, A. F., Kassel, V. M. & Denmark, S. E., Nov 15 2024, In: Journal of Organic Chemistry. 89, 22, p. 16170-16184 15 p. Machine Learning to Develop Peptide Catalysts─Successes, Limitations, and Opportunities Schnitzer, T., Schnurr, M., Zahrt, A. F., Sakhaee, N., Denmark, S. E. & Wennemers, H., Feb 28 2024, In: ACS Central Science. 10, 2, p. 367-373 7 p. Molecule Maker Lab Institute: Accelerating, advancing, and democratizing molecular innovation Burke, M. D., Denmark, S. E., Diao, Y., Han, J., Switzky, R. & Zhao, H., Mar 1 2024, In: AI Magazine. 45, 1, p. 117-123 7 p. molli: A General Purpose Python Toolkit for Combinatorial Small Molecule Library Generation, Manipulation, and Feature Extraction Shved, A. S., Ocampo, B. E., Burlova, E. S., Olen, C. L., Rinehart, N. I. & Denmark, S. E., Nov 11 2024, In: Journal of Chemical Information and Modeling. 64, 21, p. 8083-8090 8 p. Organoselenium-Catalyzed Enantioselective Synthesis of 2-Oxazolidinones from Alkenes Cunningham, C. C., Panger, J. L., Lupi, M. & Denmark, S. E., Aug 9 2024, In: Organic Letters. 26, 31, p. 6703-6708 6 p. Rapid, Homogenous, B-Alkyl Suzuki-Miyaura Cross-Coupling of Boronic Esters Bock, M. J. & Denmark, S. E., Nov 15 2024, In: Journal of Organic Chemistry. 89, 22, p. 16195-16202 8 p. A machine-learning tool to predict substrate-adaptive conditions for Pd-catalyzed C–N couplings Rinehart, N. I., Saunthwal, R. K., Wellauer, J., Zahrt, A. F., Schlemper, L., Shved, A. S., Bigler, R., Fantasia, S. & Denmark, S. E., Sep 1 2023, In: Science. 381, 6661, p. 965-972 8 p. Extrapolative prediction of enantioselectivity enabled by computer-driven workflow, new molecular representations and machine learning Denmark, S. E. (Inventor), Zahrt, A. F. (Inventor), Henle, J. J. (Inventor), Rose, B. T. (Inventor), Wang, Y. (Inventor) & Darrow, W. (Inventor), May 30 2023, U.S. Patent No. 11664093, Aug 26 2019 Non-invasive Analysis Of Embryo Metabolites Rubessa, M. (Inventor), Wheeler, M. B. (Inventor), Ambrosi, A. (Inventor), Denmark, S. E. (Inventor) & Gonzalez-Pena, D. (Inventor), Oct 3 2023, U.S. Patent No. 11774454 Application of Machine Learning and Reaction Optimization for the Iterative Improvement of Enantioselectivity of Cinchona-Derived Phase Transfer Catalysts Lexa, K. W., Belyk, K. M., Henle, J., Xiang, B., Sheridan, R. P., Denmark, S. E., Ruck, R. T. & Sherer, E. C., Mar 18 2022, In: Organic Process Research and Development. 26, 3, p. 670-682 13 p. Enantioselective Inter- and Intramolecular Sulfenofunctionalization of Unactivated Cyclic and (Z)-Alkenes Matviitsuk, A., Panger, J. L. & Denmark, S. E., 2022, In: ACS Catalysis. 12, p. 7377-7385 9 p. Extraction of selected platinum-group metals from supported catalyst Denmark, S. E. (Inventor) & Ibrahim, M. Y. S. (Inventor), Aug 30 2022, U.S. Patent No. 11427887, Nov 26 2018 High-Level Data Fusion Enables the Chemoinformatically Guided Discovery of Chiral Disulfonimide Catalysts for Atropselective Iodination of 2-Amino-6-arylpyridines Rose, B. T., Timmerman, J. C., Bawel, S. A., Chin, S., Zhang, H. & Denmark, S. E., Dec 21 2022, In: Journal of the American Chemical Society. 144, 50, p. 22950-22964 15 p. Potassium Trimethylsilanolate-Promoted, Anhydrous Suzuki-Miyaura Cross-Coupling Reaction Proceeds via the "boronate Mechanism": Evidence for the Alternative Fork in the Trail Delaney, C. P., Marron, D. P., Shved, A. S., Zare, R. N., Waymouth, R. M. & Denmark, S. E., Mar 16 2022, In: Journal of the American Chemical Society. 144, 10, p. 4345-4364 20 p. A Conformer-Dependent, Quantitative Quadrant Model Zahrt, A. F., Rinehart, N. I. & Denmark, S. E., May 7 2021, In: European Journal of Organic Chemistry. 2021, 17, p. 2343-2354 12 p. A Unified Strategy for the Asymmetric Synthesis of Highly Substituted 1,2-Amino Alcohols Leading to Highly Substituted Bisoxazoline Ligands Shrestha, B., Rose, B. T., Olen, C. L., Roth, A., Kwong, A. C., Wang, Y. & Denmark, S. E., Feb 19 2021, In: Journal of Organic Chemistry. 86, 4, p. 3490-3534 45 p. Catalytic, Enantioselective Diamination of Alkenes Tao, Z. L. & Denmark, S. E., Nov 3 2021, In: Synthesis (Germany). 53, 21, p. 3951-3962 12 p., ss-2021-r0324-sr. Catalytic, Enantioselective Syn-Oxyamination of Alkenes Mumford, E. M., Hemric, B. N. & Denmark, S. E., Aug 25 2021, In: Journal of the American Chemical Society. 143, 33, p. 13408-13417 10 p. Computational methods for training set selection and error assessment applied to catalyst design: Guidelines for deciding which reactions to run first and which to run next Zahrt, A. F., Rose, B. T., Darrow, W. T., Henle, J. J. & Denmark, S. E., Apr 2021, In: Reaction Chemistry and Engineering. 6, 4, p. 694-708 15 p. Dreams, False Starts, Dead Ends, and Redemption: A Chronicle of the Evolution of a Chemoinformatic Workflow for the Optimization of Enantioselective Catalysts Rinehart, N. I., Zahrt, A. F., Henle, J. J. & Denmark, S. E., May 4 2021, In: Accounts of chemical research. 54, 9, p. 2041-2054 14 p. Heteroaryl-Heteroaryl, Suzuki-Miyaura, Anhydrous Cross-Coupling Reactions Enabled by Trimethyl Borate Kassel, V. M., Hanneman, C. M., Delaney, C. P. & Denmark, S. E., Sep 1 2021, In: Journal of the American Chemical Society. 143, 34, p. 13845-13853 9 p. Leveraging Machine Learning for Enantioselective Catalysis: From Dream to Reality Rinehart, N. I., Zahrt, A. F. & Denmark, S. E., Aug 2021, In: Chimia. 75, 7-8, p. 592-597 6 p. Lewis Base Catalyzed, Sulfenium Ion Initiated Enantioselective, Spiroketalization Cascade Hilby, K. M. & Denmark, S. E., Nov 5 2021, In: Journal of Organic Chemistry. 86, 21, p. 14250-14289 40 p. Stereochemical language in supramolecular polymer chemistry: How we can do better Palmans, A. R. A., Meijer, E. W. & Denmark, S. E., Jun 15 2021, In: Journal of Polymer Science. 59, 12, p. 1171-1174 4 p. Synthesis of Enantioenriched 3,4-Disubstituted Chromans through Lewis Base Catalyzed Carbosulfenylation Menard, T., Laverny, A. & Denmark, S. E., Nov 5 2021, In: Journal of Organic Chemistry. 86, 21, p. 14290-14310 21 p. Anhydrous, homogeneous, suzuki-miyaura cross-coupling of boronic esters using potassium trimethylsilanolate Delaney, C. P., Heyboer, E. M. & Denmark, S. E., 2020, In: Organic Syntheses. 97, p. 245-261 17 p. Asymmetric Hydrogenation of Unfunctionalized Tetrasubstituted Acyclic Olefins Bigler, R., Mack, K. A., Shen, J., Tosatti, P., Han, C., Bachmann, S., Zhang, H., Scalone, M., Pfaltz, A., Denmark, S. E., Hildbrand, S. & Gosselin, F., Feb 10 2020, In: Angewandte Chemie - International Edition. 59, 7, p. 2844-2849 6 p. Catalytic, Enantioselective Sulfenofunctionalization of Alkenes: Development and Recent Advances Matviitsuk, A., Panger, J. L. & Denmark, S. E., Nov 2 2020, In: Angewandte Chemie - International Edition. 59, 45, p. 19796-19819 24 p. Cautionary Guidelines for Machine Learning Studies with Combinatorial Datasets Zahrt, A. F., Henle, J. J. & Denmark, S. E., Nov 9 2020, In: ACS Combinatorial Science. 22, 11, p. 586-591 6 p. Demystifying the asymmetry-amplifying, autocatalytic behaviour of the Soai reaction through structural, mechanistic and computational studies Athavale, S. V., Simon, A., Houk, K. N. & Denmark, S. E., Apr 1 2020, In: Nature Chemistry. 12, 4, p. 412-423 12 p. Development of a Computer-Guided Workflow for Catalyst Optimization. Descriptor Validation, Subset Selection, and Training Set Analysis Henle, J. J., Zahrt, A. F., Rose, B. T., Darrow, W. T., Wang, Y. & Denmark, S. E., Jul 1 2020, In: Journal of the American Chemical Society. 142, 26, p. 11578-11592 15 p. Enantioselective Synthesis of γ-Lactams by Lewis Base Catalyzed Sulfenoamidation of Alkenes Panger, J. L. & Denmark, S. E., Apr 3 2020, In: Organic Letters. 22, 7, p. 2501-2505 5 p. Potassium trimethylsilanolate enables rapid, homogeneous suzuki-miyaura cross-coupling of boronic esters Delaney, C. P., Kassel, V. M. & Denmark, S. E., Jan 3 2020, In: ACS Catalysis. 10, 1, p. 73-80 8 p. Quantitative Structure-Selectivity Relationships in Enantioselective Catalysis: Past, Present, and Future Zahrt, A. F., Athavale, S. V. & Denmark, S. E., Feb 12 2020, In: Chemical reviews. 120, 3, p. 1620-1689 70 p. Structural contributions to autocatalysis and asymmetric amplification in the soai reaction Athavale, S. V., Simon, A., Houk, K. N. & Denmark, S. E., Oct 28 2020, In: Journal of the American Chemical Society. 142, 43, p. 18387-18406 20 p.