Administrative duties

Director of Biomedical Science Deputy Head of School, Biological, Biomedical and Environmental Sciences Admissions officer for Biomedical Science Elected Member of Senate

Memberships, Fellowships and Representative Roles

Member of the International Society for Heart Research (European Section) Member of the British Society for Cardiovascular Research Member of the American Physiological Society Fellow, Institute of Biomedical Science Elected Representative on Heads of University Centres of Biomedical Science (HUCBMS)

My research is aimed at understanding the cellular basis of heart failure. In particular the work focuses on three key areas;

the role of metabolic remodelling in cardiac dysfunction in hypertrophy insulin resistance and cell loss in heart failure cellular mechanisms underlying uraemic cardiomyopathy.

Seymour A-M, Reddy V, Bhandari S (2013) Cardiac effects of carnitine supplementation in experimental uraemia Front Biosci (Elite Ed). 5:834-44. Semple DJ, Bhandari S, Seymour A-M (2012). Uremic cardiomyopathy is characterised by loss of the insulin cardioprotective effects of insulin. Am J Physiol Renal Physiol. 303:F1275-86 Dodd MS, Ball DR, Schroeder MA, Le Page LM, Atherton HJ, Heather LC, Seymour AM, Ashrafian H, Watkins H, Clarke K, Tyler DJ (2012) In vivo alterations in cardiac metabolism and function in experimental hypertension. Cardiovasc Res. 95:69-76. Semple D, Smith K, Bhandari S, Seymour A-M (2011). Uremic cardiomyopathy and insulin resistance - a critical role for Akt? J Am Soc Nephrol. 22:207-15 Smith K, Semple D, Aksentijevic D, Bhandari S, Seymour A-M (2010). Functional and metabolic adaptations in uraemic cardiomyopathy Front Biosci (Elite Ed).2:1492-501.