NIH Postdoctoral Fellow, California Institute of Technology, 2011-2013 Ph.D., Massachusetts Institute of Technology, 2011 B.S., University of California - San Diego, 2006

Synthetic and Biosynthetic Chemistry

Research in the Do laboratory focuses primarily on pushing forward the frontiers in biosynthetic chemistry, particularly in areas relating to medicine and renewable fuels. By taking a bottom-up approach, where unmet technological challenges are deconstructed and evaluated through fundamental chemistry, we hope to discover solutions that will have meaningful real world impact.

Projects in the group explore the use of small-molecule metal complexes in living systems, taking advantage of the specific chemical bond-making and bond-breaking events mediated by such species to effect catalytic bioorthogonal reactions. Due to the multi-disciplinary nature of our research, work in the group ranges from preparation and characterization of organic/inorganic/organometallic compounds to performing bioassays and cell culture studies to cellular imaging.

Anh H. Ngo, Michael J. Adams, Loi H. Do.* “Selective Acceptorless Dehydrogenation and Hydrogenation by Iridium Catalysts Enabling Facile Interconversion of Glucocorticoids.” Organometallics, 2014, ASAP. DOI: DOI: 10.1021/om5010258. Article.

Yunbo Jiang, Takahiro Hayashi, Hirotoshi Matsumura, Loi H. Do, Amit Majumdar, Stephen J. Lippard,* and Pierre Moënne-Loccoz.* “Light-Induced N2O Production from a Non-heme Iron–Nitrosyl Dimer” J. Am. Chem. Soc., 2014, 136(36), 12524-12527. DOI: 10.1021/ja504343t

Do, L. H.; Labinger, J. A.; Bercaw, J. E. Spectral Studies of a Cr(PNP)-MAO System for Selective Ethylene Trimerization Catalysis: Searching for the Active Species. ACS Catalysis, 2013, 3(11), 2582-2585. DOI: 10.1021/cs400778a

Do, L. H.; Labinger, J. A.; Bercaw, J. E. Mechanistic Studies of Ethylene and Alpha Olefin Co-Oligomerization Catalyzed by Chromium-PNP Complexes. Organometallics, 2012, 31(14), 5143-5149. DOI: 10.1021/om300492r

Li, Y.; Wilson, J. J.; Do, L. H.; Apfel, U.-P.; Lippard, S. J. A C2-Symmetric, Basic Iron Acetate Complex Derived from a Novel Preorganized Triptycene-Based Chelating Carboxylate Ligand.” Dalton Transaction, 2012, 41, 9272-9275. DOI: 10.1039/C2DT31260C

Do, L. H.; Xue, G.; Que, L., Jr.; Lippard, S. J. Evaluating the Identity and Diiron Core Transformations of a (μ-Oxo)diiron(III) Complex Supported by Electron-Rich Tris(pyridyl-2-methyl)amine Ligands. Inorganic Chemistry, 2012, 51(4), 2393-2402. DOI: 10.1021/ic202379b

Do, L. H.; Wang, H.; Tinberg, C. E.; Dowty, E.; Yoda, Y.; Cramer, S. P.; Lippard, S. J. Characterization of a Synthetic Peroxodiiron(III) Protein Model Complex by Nuclear Resonance Vibrational Spectroscopy. Chemical Communications, 2011, 47, 10945-10947. DOI: 10.1039/C1CC13836G

Do, L. H.; Lippard, S. J. Evolution of Strategies to Prepare Synthetic Mimics of Carboxylate-Bridged Diiron Protein Active Sites. Journal of Inorganic Biochemistry, 2011, 105(12), 1774-1785. DOI: 10.1016/j.jinorgbio.2011.08.025

Do, L. H.; Lippard, S. J. Toward Carboxylate-Bridged Diiron Protein Mimics: Achieving Structural Stability and Conformational Flexibility Using a Macrocyclic Ligand Framework. Journal of the American Chemical Society, 2011, 133(27), 10568-10581. DOI: 10.1021/ja2021312

Alliger, G. E.; Müller, P.; Do, L. H.; Cummins, C. C.; Nocera, D. G. A Family of Cofacial Bimetallic Complexes of Hexaanionic Carboxamide Cryptands. Inorganic Chemistry, 2011, 50(9), 4107-4115. DOI:10.1021/ic200143b

Tonzetich, Z. J.; Héroguel, F.; Do, L. H.; Lippard, S. J. Chemistry of Nitrosyl Iron Complexes Supported by a β-Diketiminate Liagnd. Inorganic Chemistry, 2010, 50(4), 1570-1579. DOI: 10.1021/ic102300d

Tinberg, C. E.; Tonzetich, Z. J.; Wang, H.; Do, L. H.; Yoda, Y.; Cramer, S. P.; Lippard, S. J. Characterization of Iron Dinitrosyl Species Formed in the Reaction of Nitric Oxide with a Biological Rieske Center. Journal of the American Chemical Society, 2010, 132(20), 6914-6916. DOI: 10.1021/ja101002f

Tonzetich, Z. J.; Wang, H.; Mehta, D.; Tinberg, C. E.; Do, L. H.; Jenney, F.; Cramer, S. P.; Lippard, S. J. Identification of Protein-Bound Dinitrosyl Iron Complexes by Nuclear Resonance Vibrational Spectroscopy. Journal of the American Chemical Society, 2010, 132(20), 6914–6916. DOI: 10.1021/ja101002f

Do, L. H.; Hayashi, T.; Moënne-Loccoz, P.; Lippard, S. J. Carboxylate as the Protonation Site in (Peroxo)diiron(III) Model Complexes of Soluble Methane Monooxygenase and Related Diiron Proteins. Journal of the American Chemical Society, 2010, 132(4), 1273–1275. DOI: 10.1021/ja909718f

Do, L. H.; Lippard, S. J. 2-Phenoxypyridyl Dinucleating Ligands for Assembly of Diiron(II) Complexes; Efficient Reactivity with O2 to Form -Oxodiiron(III) units. Inorganic Chemistry, 2009, 48(22), 10708–10719. DOI: 10.1021/ic901711c

Tonzetich, Z. J.; Do, L. H.; Lippard, S. J. Dinitrosyl Iron Complexes Relevant to Rieske Nitrosylation. Journal of the American Chemical Society, 2009, 131(23), 7964–7965. DOI: 10.1021/ja9030159

Tennyson, A. G.; Do, L.; Smith, R. C.; Lippard, S. J. Selective Fluorescence Detection of Nitroxyl over Nitric Oxide in Buffered Aqueous Solution using a Conjugated Metallopolymer. Polyhedron, 2007, 26, 4625–4630. DOI: 10.1016/j.poly.2007.04.003

Halper, S. R.; Do, L.; Stork, J. R.; Cohen, S. M. Topological Control in Heterometallic Metal-Organic Frameworks by Anion Templating and Metalloligand Design. Journal of the American Chemical Society, 2006, 128(47), 15255–15268. DOI: 10.1021/ja0645483

Do, L.; Smith, R. C.; Tennyson, A. G.; Lippard, S. J. Luminescent Properties of Water-Soluble Conjugated Metallopolymers and their Application to Fluorescent Nitric Oxide Detection. Inorganic Chemistry, 2006, 45(22), 8998–9005. DOI: 10.1021/ic060998k

Do, L.; Halper, S. H.; Cohen, S. M. Helical Coordination Polymers and Cyclic Dimers Formed from Heteroleptic Thioether-Dipyrrinato Copper(II) Complexes. Chemical Communications, 2004, 2662–2663. DOI: 10.1039/B411991F"