Ho Leung Ng grew up in Hawaii and went on to receive his B.A. in Biochemistry from Harvard University. He received his Ph.D. fromUCLA working with David Eisenberg and Richard Dickerson on biomacromolecular x-ray crystallography and bioinformatics. He worked with Tom Alber at UC Berkeley for his postdoctoral research, studying experimental and computational protein crystallography, focusing on protein kinases and protein complexes. After Berkeley, he worked on membrane protein crystallography of G-protein coupled receptors at a biotechnology company. He joined the faculty of the Department of Chemistry of the University of Hawaii at Manoa in August 2011.