My research interests are in using the technique of protein crystallography to elucidate protein structure with an aim to answering important questions on protein function and mechanism. I also have a specific interest in protein-protein interactions. Protein Structure and Function; Enzymes of the Shikimate pathway; Structure aided drug discovery; Protein Crystallography; Plant Glutathione S-transferases.

"Binding and glutathione conjugation of porphyrinogens by plant glutathione transferases". Dixon, D.P., Lapthorn, A.J., Madesis, P., Mudd, E.A., Day, A. and Edwards, R. J. Biol. Chem. 283, 20268-20276 (2008) "Design, synthesis, and structural studies on potent biaryl inhibitors of type II dehydroquinases". Payne, R.J., Riboldi-Tunnicliffe, A., Kerbarh, O., Abell, A.D., Lapthorn, A.J. and Abell, C. ChemMedChem, 2, 1010-1013 (2007) "Crystal structures of Helicobacter pylori type II dehydroquinase inhibitor complexes: New directions for inhibitor design". D.A. Robinson, K.A. Stewart, N.C. Price, P.A. Chalk, J.R. Coggins, A.J. Lapthorn, J. Med. Chem., 49, 1282-1290 (2006) "Crystal structure of mouse succinic semialdehyde reductase AKR7A5: Structural basis for substrate specificity". X.F. Zhu, A.J. Lapthorn, E.M. Ellis, Biochemistry, 45, 1562-1570 (2006) "The structure of Escherichia coli ATP-phosphoribosyltransferase: Identification of substrate binding sites and mode of AMP inhibition". B. Lohkamp, G. McDermott, S.A. Campbell, J.R. Coggins, A.J. Lapthorn, J. Mol. Biol., 336, 131-144 (2004)