Ph.D., 2002, Purdue University

Cell mechanics Cell and tissue engineering Quantitative cell biology

The nucleus is an intracellular propagator of tensile forces in NIH 3T3 fibroblasts. Alam SG, Lovett D, Kim DI, Roux K, Dickinson RB, Lele TP. Journal of Cell Science. 2015 Apr 23. pii: jcs.161703 Direct force probe reveals the mechanics of nuclear homeostasis in the mammalian cell. Neelam S, Chancellor TJ, Li Y, Nickerson JA, Roux KJ, Dickinson RB, Lele TP. Proceedings of the National Academy of Sciences U S A. 2015 Apr 21. pii: 201502111 Actomyosin pulls to advance the nucleus in a migrating tissue cell. Wu J, Kent IA, Shekhar N, Chancellor TJ, Mendonca A, Dickinson RB, Lele TP. Biophysical Journal 2014 Jan 7;106(1):7-15. doi: 10.1016/j.bpj.2013.11.4489. Modulation of Nuclear Shape by Substrate Rigidity. Lovett DB, Shekhar N, Nickerson JA, Roux KJ, Lele TP. Cell Molecular Bioengineering. 2013 Jun 1;6(2):230-238. Effects of dynein on microtubule mechanics and centrosome positioning. Wu J, Misra G, Russell RJ, Ladd AJ, Lele TP, Dickinson RB. Mol Biol Cell. 2011 Dec;22(24):4834-41. doi: 10.1091/mbc.E11-07-0611