Biomolecular Mass Spectrometry, Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS), Top-Down Mass Spectrometry, Protein Chemistry, Enzymology, Structural Biology.

Redox Regulation of Tumour Suppressor Protein p53: Identification of the Sites of Hydrogen Peroxide Oxidation and Glutathionylation. D. J. Clarke*, J. Scotcher*, C. L. Mackay, T. Hupp, P. J. Sadler, and P. R. R. Langridge-Smith. Chemical Science, 2013, 4, 1257-1269. Probing the conformational diversity of cancer-associated mutations in p53 by Ion Mobility-Mass Spectrometry. E. Jurneczko, F. Cruickshank, M. Porrini, D. J. Clarke, I. D. G. Campuzano, M. Morris, P. V. Nikolova, and P. E. Barran. Angew. Chem. Int. Ed., 2013, 52, 4370-4374. The chemical basis of serine palmitoyltransferase inhibition by myriocin. D. J. Clarke*, J. M. Wadsworth*, S. A. McMahon, J. P. Lowther, A. E. Beattie, H. Broughton, T. M. Dunn, J. H. Naismith, and D. J. Campopiano. J. Am. Chem. Soc., 2013, 38, 14276. Cellular Redox Potential and the Biomolecular Electrochemical Series: A Systems Hypothesis. V. Mallikarjun, D. J. Clarke and C. J. Campbell. Free Radical Biology & Medicine, 2012, 53, 280-288. Mapping a Non-covalent Protein-Peptide Interface by Top-Down FT-ICR Mass Spectrometry using Electron Capture Dissociation. D. J. Clarke, E. Murray, T. Hupp, C. L. Mackay, and P. R. R. Langridge-Smith. J. Am. Soc. Mass Spec. 2011, 22 ,1432-1440.