Santos, Laura Carro 照片

Santos, Laura Carro

Dr

所属大学: University of East Anglia

所属学院: School of Pharmacy

邮箱:
l.carro-santos@uea.ac.uk

个人主页:
http://www.uea.ac.uk/pharmacy/people/profile/l-carro-santos

个人简介

Laura graduated in Pharmacy from the University of Santiago de Compostela (Spain) in 2004. She then undertook her Ph.D. studies under the supervision of Professor Enrique Raviña and Professor Christian Fernández Masaguer, which were focused on the synthesis of new compounds with antipsychotic activity. In 2012 Laura was awarded with a Fundación Barrié scholarship which allowed her to join as a post-doctoral researcher the Research Group led by Professor David Spring at the University of Cambridge. Whilst in Cambridge, she was involved in three different projects: Diversity-Oriented Synthesis (DOS) to obtain new molecules with anticancer activity, the synthesis of new quinolone-like structures as Quorum Sensing modulators and the synthesis of small molecules to target CK2.

In February 2016 Laura joined the School of Pharmacy of the University of East Anglia as a Lecturer in Medicinal Chemistry.

研究领域

Laura’s main research interests are focused on the synthesis of antibacterial polycyclic molecules with novel modes of action.

近期论文

The synthesis of quinolone natural products from pseudonocardia sp.Salvaggio, F.; Hodgkinson, J. T.; Carro, L.; Geddis, S. M.; Galloway, W. R. J. D.; Welch, M.; Spring, D. R.European Journal of Organic Chemistry. 2016, 3, 434-437.DOI: 10.1002/ejoc.201501400 A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffolds.Isidro-Llobet, A.; Hadje Georgiou, K.; Galloway, W. R. J. D.; Giacomini, E.; Hansen, M. R.; Méndez-Abt, G.; Tan, Y. S.; Carro, L.; Sore, H. F.; Spring, D. R.Organic and Biomolecular Chemistry, 2015, 13, 4570-4580.DOI: 10.1039/C5OB00371G Synthesis and biological evaluation of a series of aminoalkyl-tetralones and tetralols as dual dopamine/serotonin ligands.Carro, L.; Torrado, M.; Raviña, E.; Masaguer, C. F.; Lage, S.; Brea, J.; Loza, M. I.European Journal of Medicinal Chemistry, 2014, 71, 237-249.DOI: 10.1016/j.ejmech.2013.10.066 Synthesis and binding affinity of new 1,4-disubstituted triazoles as potential dopamine D3 receptor ligands.Insua, I.; Alvarado, M.; Masaguer, C. F.; Iglesias, A.; Brea, J.; Loza, M. I.; Carro, L.Bioorganic and Medicinal Chemistry Letters, 2013, 23, 5586-5591.DOI: 10.1016/j.bmcl.2013.08.047 Synthesis and binding affinity of potential atypical antipsychotics with the tetrahydroquinazolinone motif.Carro, L.; Raviña, E.; Domínguez, E.; Brea, J.; Loza, M. I.; Masaguer, C. F.Bioorganic and Medicinal Chemistry Letters, 2009, 21, 6059-6062.DOI: 10.1016/j.bmcl.2009.09.041