Walden, Helen 照片

Walden, Helen

Professor

所属大学: University of Dundee

所属学院: School of Life Sciences

邮箱:
h.walden@dundee.ac.uk

个人主页:
http://www.lifesci.dundee.ac.uk/people/helen-walden

近期论文

Kumar, A.*, Aguirre, J.D.*, Condos, T.E.C.*, Martinez-Torres, R.J.*, Chaugule, V.K., Toth, R., Sundaramoorthy, R., Mercier, P., Knebel, A., Spratt, D.E., Barber, K.R., Shaw, G.S.*, and Walden, H*. (2015)Disruption of the autoinhibited state primes the E3 ligase Parkin for activation and catalysis.EMBO J 34 p.2506-21 DOI:10.15252/embj.201592337.(Cover Story and News & Views piece “pUBLically unzipping parkin” by Dove, Klevit & Rittinger) Miles, J.A., Frost, M.G., Carroll, E., Rowe, M.L., Howard, M.J., Sidhu, A., Chaugule, V.K., Alpi, A.F.*, and Walden, H*. (2015)The Fanconi Anemia DNA repair pathway is regulated by an interaction between ubiquitin and the E2-like fold domain of FANCL.J Biol Chem 10.1074/jbc.M115.675835 Hodson, C., Purkiss, A., Miles, J.A. and H. Walden. (2014)Structure of the human FANCL RING-Ube2T complex reveals determinants of cognate E3-E2 selection.Structure 22, p337-344. Spratt, D. E.*, Martinez-Torres, R. J.*, Noh, Y. J.*, Mercier, P., Manczyk, N., Barber, K. R., Aguirre, J. D., Burchell, L., Purkiss, A., Walden, H*. and Shaw, G. S*. (2013).A molecular explanation for the recessive nature of parkin-linked Parkinson's disease.Nat Commun 4, 1983(with accompanying perspectives in EMBO J and Current Biology) Burchell, L., Chaugule, V. K. and Walden, H. (2012).Small, N-terminal tags activate Parkin E3 ubiquitin ligase activity by disrupting its autoinhibited conformation.PloS one 7, e34748 Hodson, C., Cole, A. R., Lewis, L. P., Miles, J. A., Purkiss, A. and Walden, H. (2011).Structural analysis of human FANCL, the E3 ligase in the Fanconi anemia pathway.J Biol Chem 286, 32628-32637 Chaugule, V. K., Burchell, L., Barber, K. R., Sidhu, A., Leslie, S. J., Shaw, G. S. and Walden, H. (2011).Autoregulation of Parkin activity through its ubiquitin-like domain.Embo J 30, 2853-2867(with an accompanying news and views article “Policing Parkin with a UblD” by Fen Liu and Kylie Walters, p. 2757-2758). Cole, A. R., Lewis, L. P. and Walden, H. (2010).The structure of the catalytic subunit FANCL of the Fanconi anemia core complex.Nat Struct Mol Biol 17, 294-298 Walden, H., Podgorski, M. S. and Schulman, B. A. (2003).Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8.Nature 422, 330-334(A news and views piece covering this paper is in Nature Structural Biology, (2003), 10 244-246: Two-stepping with E1. A.P. VanDemark and C.P. Hill.) Walden, H., Podgorski, M. S., Huang, D. T., Miller, D. W., Howard, R. J., Minor, D. L., Jr., Holton, J. M. and Schulman, B. A. (2003).The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.Mol Cell 12, 1427-1437