Kapuria, V., Rohrig, U. F., Bhuiyan, T., Borodkin, V. S., van Aalten, D. M., Zoete, V. and Herr, W. (2016) Proteolysis of HCF-1 by Ser/Thr glycosylation-incompetent O-GlcNAc transferase:UDP-GlcNAc complexes. Genes & development. 30, 960-972 Raich, L., Borodkin, V., Fang, W., Castro-Lopez, J., van Aalten, D. M., Hurtado-Guerrero, R. and Rovira, C. (2016) A Trapped Covalent Intermediate of a Glycoside Hydrolase on the Pathway to Transglycosylation. Insights from Experiments and Quantum Mechanics/Molecular Mechanics Simulations. Journal of the American Chemical Society. 138, 3325-3332 Swamy, M., Pathak, S., Grzes, K. M., Damerow, S., Sinclair, L. V., van Aalten, D. M. and Cantrell, D. A. (2016) Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy. Nature immunology. 17, 712-720 Trapannone, R., Mariappa, D., Ferenbach, A. T. and van Aalten, D. M. (2016) Nucleocytoplasmic human O-GlcNAc transferase is sufficient for O-GlcNAcylation of mitochondrial proteins. The Biochemical journal Trapannone, R., Rafie, K. and van Aalten, D. M. (2016) O-GlcNAc transferase inhibitors: current tools and future challenges. Biochemical Society transactions. 44, 88-93 Fang, W., Robinson, D. A., Raimi, O. G., Blair, D. E., Harrison, J. R., Lockhart, D. E., Torrie, L. S., Ruda, G. F., Wyatt, P. G., Gilbert, I. H. and van Aalten, D. M. (2015) N-myristoyltransferase is a cell wall target in Aspergillus fumigatus. ACS Chem Biol. 10, 1425-1434 Jank, T., Eckerle, S., Steinemann, M., Trillhaase, C., Schimpl, M., Wiese, S., van Aalten, D. M., Driever, W. and Aktories, K. (2015) Tyrosine glycosylation of Rho by Yersinia toxin impairs blastomere cell behaviour in zebrafish embryos. Nat Commun. 6, 7807 Kazlauskaite, A., Martinez-Torres, R. J., Wilkie, S., Kumar, A., Peltier, J., Gonzalez, A., Johnson, C., Zhang, J., Hope, A. G., Peggie, M., Trost, M., van Aalten, D. M., Alessi, D. R., Prescott, A. R., Knebel, A., Walden, H. and Muqit, M. M. (2015) Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation. EMBO Rep. 16, 939-954 Mariappa, D., Selvan, N., Borodkin, V. S., Alonso, J., Ferenbach, A. T., Shepherd, C., Navratilova, I. H. and van Aalten, D. M. (2015) A mutant O-GlcNAcase as a probe to reveal global dynamics of protein O-GlcNAcylation during Drosophila embryonic development. Biochem J. 470, 255-262 Mariappa, D., Zheng, X., Schimpl, M., Raimi, O., Ferenbach, A. T., Muller, H. A. and van Aalten, D. M. (2015) Dual functionality of O-GlcNAc transferase is required for Drosophila development. Open Biol. 5 Ostrowski, A., Gundogdu, M., Ferenbach, A. T., Lebedev, A. A. and van Aalten, D. M. (2015) Evidence for a Functional O-Linked N-Acetylglucosamine (O-GlcNAc) System in the Thermophilic Bacterium Thermobaculum terrenum. J Biol Chem. 290, 30291-30305 Pathak, S., Alonso, J., Schimpl, M., Rafie, K., Blair, D. E., Borodkin, V. S., Schuttelkopf, A. W., Albarbarawi, O. and van Aalten, D. M. (2015) The active site of O-GlcNAc transferase imposes constraints on substrate sequence. Nat Struct Mol Biol. 22, 744-750 Selvan, N., Mariappa, D., van den Toorn, H. W., Heck, A. J., Ferenbach, A. T. and van Aalten, D. M. (2015) The Early Metazoan Trichoplax adhaerens Possesses a Functional O-GlcNAc System. J Biol Chem. 290, 11969-11982 van der Beek, S. L., Le Breton, Y., Ferenbach, A. T., Chapman, R. N., van Aalten, D. M., Navratilova, I., Boons, G. J., McIver, K. S., van Sorge, N. M. and Dorfmueller, H. C. (2015) GacA is essential for Group A Streptococcus and defines a new class of monomeric dTDP-4-dehydrorhamnose reductases (RmlD). Mol Microbiol Zhang, N., Gordon, S. L., Fritsch, M. J., Esoof, N., Campbell, D. G., Gourlay, R., Velupillai, S., Macartney, T., Peggie, M., van Aalten, D. M., Cousin, M. A. and Alessi, D. R. (2015) Phosphorylation of synaptic vesicle protein 2A at Thr84 by casein kinase 1 family kinases controls the specific retrieval of synaptotagmin-1. J Neurosci. 35, 2492-2507 Alonso, J., Schimpl, M. and van Aalten, D. M. (2014) O-GlcNAcase: promiscuous hexosaminidase or key regulator of O-GlcNAc signaling? J Biol Chem. 289, 34433-34439 Borodkin, V. S., Schimpl, M., Gundogdu, M., Rafie, K., Dorfmueller, H. C., Robinson, D. A. and van Aalten, D. M. (2014) Bisubstrate UDP-peptide conjugates as human O-GlcNAc transferase inhibitors. Biochem J. 457, 497-502 Brand, S., Norcross, N. R., Thompson, S., Harrison, J. R., Smith, V. C., Robinson, D. A., Torrie, L. S., McElroy, S. P., Hallyburton, I., Norval, S., Scullion, P., Stojanovski, L., Simeons, F. R. C., van Aalten, D., Frearson, J. A., Brenk, R., Fairlamb, A. H., Ferguson, M. A. J., Wyatt, P. G., Gilbert, I. H. and Read, K. D. (2014) Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma brucei N-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis. Journal of Medicinal Chemistry. 57, 9855-9869 Dorfmueller, H. C., Ferenbach, A. T., Borodkin, V. S. and van Aalten, D. M. (2014) A structural and biochemical model of processive chitin synthesis. J Biol Chem. 289, 23020-23028