Adrian graduated with first class honours from the University of Leeds in 1997 before moving to London to study for a PhD at Kings College in Professor Michael Marber’s laboratory at the Department of Cardiology. Following his PhD, Adrian moved to the Protein Phosphorylation laboratory at CRUK’s London Research Institute (headed by Professor Peter Parker), where he first became fascinated by the process of cell division. He subsequently moved to UMC Utrecht, in The Netherlands, to study the role of protein kinases during mitosis in the lab of Professor Geert Kops. Adrian relocated back to the UK in March 2013 to set up his own lab in Dundee studying the spatial regulation of mitotic signalling networks.

Vallardi G, Cordeiro MH and Saurin AT. A kinase-phosphatase network that regulates kinetochore-microtubule attachments and the SAC. Progress in Molecular and Subcellular Biology. In Press Saurin AT and Kops GJPL. Studying kinetochore kinases. Methods in Molecular Biology. 2016; 1413:333-47. Mchedlishvili N, Joank K and Saurin AT. Meeting report – Getting Into and Out of Mitosis. J Cell Sci. 2015; 128(22): 4035-8 Vallardi G and Saurin AT. Mitotic kinases and phosphatases cooperate to shape the right response. Cell Cycle. 2015. 14(6): 795-6 Nijenhuis W, Vallardi G, Teixeira A, Kops GJ, Saurin AT. Negative feedback at kinetochores underlies a responsive spindle checkpoint signal. Nature Cell Biology. 2014. Dec;16(12):1257-64. Mullers E, Cascales HS, Jaiswal H, Saurin AT, Lindqvist A. Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase. Cell Cycle. 2014 13:17, 2733-2743 Kuijt T, Omerzu M, Saurin AT, and Kops GJPL. Conditional targeting of Mad1 to kinetochores is sufficient to reactivate the spindle assembly checkpoint in metaphase. Chromosoma. 123(5):471-80. Shaltiel IA, Aprelia M, Saurin AT, Chowdhury D, Kops GJPL, Voest EE, Medema RH. Distinct phosphatases antagonize the p53 response in different phases of the cell cycle. PNAS. 2014. 20;111(20):7313-8. Akopyan K, Silva Cascales H, Hukasova E, Saurin AT, Müllers E, Jaiswal H, Hollman DA, Kops GJ, Medema RH, Lindqvist A. Assessing kinetics from fixed cells reveals activation of the mitotic entry network at the s/g2 transition. Molecular Cell. 2014 53(5); 843-853. *Van der Waal MS, *Saurin AT, Vromans MJ, Vleugel M, Wurzenberger C, Gerlich D Kops GJPL, Lens SMA. Mps1 promotes rapid centromere accumulation of Aurora B. EMBO reports. 2012 Sep;13(9):847-54. *equal contribution Cameron AJ, Linch MD, Saurin AT, Escribano C, Parker PJ. mTORC2 targets AGC kinases through Sin1-dependent recruitment. Biochem J. 2011 Oct 15;439(2):287-97. Saurin AT, van der Waal MS, Medema RH, Lens SMA, Kops GJPL. Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis. Nature Communications. 2011 May;.2:316 doi: 10.1038/ncomms1319 Kops GJ, Saurin AT, Meraldi P. Finding the middle ground: how kinetochores power chromosome congression. Cellular and Molecular Life Sciences. 2010 Jul;67(13):2145-61. Kostelecky B, Saurin AT, Purkiss A, Parker PJ, McDonald NQ. Recognition of an intra-chain tandem 14-3-3 binding site within PKCepsilon. EMBO reports. 2009 Sep;10(9):983-9. Cameron AJ, Escribano C, Saurin AT, Kostelecky B, Parker PJ. PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity. Nature Structural and Molecular Biology. 2009 Jun;16(6):624-30. Saurin AT, Durgan J, Cameron AJ, Faisal A, Marber MS, Parker PJ. The regulated assembly of a PKCepsilon complex controls the completion of cytokinesis. Nature Cell Biology. 2008 Aug;10:891-901. Saurin AT, Brownlow N, Parker PJ. Protein kinase C epsilon in cell division: control of abscission. Cell Cycle. 2009 Feb 15;8(4):549-55. Saurin, AT, Neubert, H, Brennan, JP, Eaton P. Widespread sulfenic acid formation in tissue in response to hydrogen peroxide. PNAS. 2004. Dec:101(52):17982-87. Saurin, AT., Pennington, DJ., Raat NJH., Owen MJ., Marber MS. Targeted disruption of the protein kinase C-epsilon gene abolishes the infarct size reduction that follows ischemic preconditioning of isolated buffer-perfused mouse hearts. Cardiovascular Research. 2002. Aug;55(3):672-680. Saurin, AT., Martin, JL., Heads, RJ., Foley, C., Mockridge, JW., Wright, MJ., Wang, Y., Marber MS. The role of differential activation of p38-Mitogen-activated Protein Kinase in preconditioned ventricular myocytes. FASEB Journal. 2000 Nov;14(14):2237-46.