Sapkota, Gopal
Dr
所属大学: University of Dundee
所属学院: School of Life Sciences
近期论文
Cammareri P, Rose AM, Vincent DF, Wang J, Nagano A, Libertini S, Ridgway RA, Athineos D, Coates PJ, McHugh A, Pourreyron C, Dayal JH, Larsson J, Weidlich S, Spender LC, Sapkota GP, Purdie KJ, Proby CM, Harwood CA, Leigh IM, Clevers H, Barker N, Karlsson S, Pritchard C, Marais R, Chelala C, South AP, Sansom OJ, Inman GJ. (2016) Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma. Nat Commun. 2016 Aug 25;7:12493. doi: 10.1038/ncomms12493. Fulcher, A. J., Macartney, T., Bozatzi, P., Hornberger, A., Rojas-Fernandez, A., and Sapkota, G. P. (2016) An Affinity-directed PROtein Missile (AdPROM) system for targeted proteolysis. Open Biol. Rojas-Fernandez, A., Herhaus, L., Macartney, T., Lachaud, C., Hay, R. T., and Sapkota, G. P. (2015) Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9. Sci Rep 5:9811 doi: 10.1038/srep09811 Herhaus, L., Perez-Oliva, A.B., Cozza, G., Gourlay, R., Weidlich, S., Campbell, D. G., Pinna, L. A. and Sapkota, G. P. (2015) Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization. Sci Signal. 2015 Apr 14;8(372):ra35. doi: 10.1126/scisignal.aaa0441. Herhaus, L., and Sapkota, G. P. (2014) The emerging roles of deubiquitylating enzymes (DUBs) in the TGFβ and BMP pathways. Cell Signal. 2014 Oct;26(10):2186-92. doi: 10.1016/j.cellsig.2014.06.012. Herhaus, L., Al-Salihi, M. A., Dingwell, K. S., Cummins, T. D., Wasmus, L., Vogt, J., Bruce, D. L., Macartney, T., Weidlich, S., Smith, J. C. and Sapkota, G. P. (2014). USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling. Open Biol. 4: 140065. Vogt, J., Dingwell, K. S., Herhaus, L., Gourlay, R., Macartney, T., Campbell, D., Smith, J. C. and Sapkota, G. P. (2014). Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling. Open Biol 4, pp. 130210 Herhaus, L., Al-Salihi, M.A., Macartney, T., Weidlich, S. and Sapkota, G.P. (2013) OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3. Nature Communications, 4:2519 | DOI: 10.1038/ncomms3519 Al-Salihi, M. A., Herhaus, L., Macartney, T. and Sapkota, G. P. (2012). USP11 augments TGFbeta signalling by deubiquitylating ALK5. Open Biology 2, pp. 120063 Al-Salihi, M. A., Herhaus, L. and Sapkota, G. P. (2012). Regulation of the transforming growth factor beta pathway by reversible ubiquitylation. Open Biology 2, pp. 120082