Ewan Pearson is a Professor in Diabetic Medicine at the University of Dundee, UK, and is Honorary Consultant in Diabetes and Endocrinology at Ninewells Hospital and Medical School in Dundee. He is the Director of the Dundee Clinical Academic Track and the Academy of Medical Sciences/Wellcome funded INSPIRE lead for the University. Professor Pearson obtained his medical degree from the University of Cambridge School of Clinical Medicine, UK. He undertook a Wellcome Trust Clinical Training fellowshipwith Prof Andrew Hattersley at the University of Exeter Medical School, UK and completed his PhD in the physiology and treatment of monogenic diabetes. His research interests are the phenotypic and genotypic determinants of drug response, the aetiology of young-onset diabetes and the mechanisms driving progression of diabetes. He leads the €46M IMI-DIRECT project on stratification in Type 2 diabetes and is Strand 2 lead on the ￡2.7M MRC funded MASTERMIND project. He has recently been awarded a Wellcome Trust New Investigator award to investigate drug response in Type 2 diabetes.

Research interests are in stratification of diabetes, phenotypic and genotypic determinants of drug response and the aetiology of young onset diabetes such as Maturity Onset Diabetes of the Young and Neonatal Diabetes.

Farmer, AJ, Rodgers, LR, Lonergan, M, Shields, B, Weedon, MN, Donnelly, L, Holman, RR, Pearson, ER & Hattersley, AT 2016, 'Adherence to oral glucose-lowering therapies and associations with 1-year HbA1c: A retrospective cohort analysis in a large primary care database' Diabetes Care, vol 39, no. 2, pp. 258-263. DOI: 10.2337/dc15-1194 McCreight, LJ, Bailey, CJ & Pearson, ER 2016, 'Metformin and the gastrointestinal tract' Diabetologia, vol 59, no. 3, pp. 426-435. DOI: 10.1007/s00125-015-3844-9 Connelly, PJ, Smith, N, Chadwick, R, Exley, AR, Shneerson, JM & Pearson, ER 2016, 'Recessive mutations in the cancer gene Ataxia Telangiectasia Mutated (ATM), at a locus previously associated with metformin response, cause dysglycaemia and insulin resistance' Diabetic Medicine, vol 33, no. 3, pp. 371-375. DOI: 10.1111/dme.13037 Dujic, T, Causevic, A, Bego, T, Malenica, M, Velija-Asimi, Z, Pearson, ER & Semiz, S 2016, 'Organic cation transporter 1 variants and gastrointestinal side effects of metformin in patients with Type 2 diabetes' Diabetic Medicine, vol 33, no. 4, 13040, pp. 511-514. DOI: 10.1111/dme.13040 Dawed, AY, Zhou, K & Pearson, ER 2016, 'Pharmacogenetics in type 2 diabetes: Influence on response to oral hypoglycemic agents' Pharmacogenomics and Personalized Medicine, vol 9, pp. 17-29. DOI: 10.2147/PGPM.S84854 Jones, AG, Lonergan, M, Henley, WE, Pearson, ER, Hattersley, AT & Shields, BM 2016, 'Should studies of diabetes treatment stratification correct for baseline HbA1c?' PLoS ONE, vol 11, no. 4, e0152428. DOI: 10.1371/journal.pone.0152428 Yaghootkar, H, Lotta, LA, Tyrrell, J, Smit, RAJ, Jones, SE, Donnelly, L, Beaumont, R, Campbell, A, Tuke, MA, Hayward, C, Ruth, KS, Padmanabhan, S, Jukema, JW, Palmer, CC, Hattersley, A, Freathy, RM, Langenberg, C, Wareham, NJ, Wood, AR, Murray, A, Weedon, MN, Sattar, N, Pearson, E, Scott, RA & Frayling, TM 2016, 'Genetic evidence for a link between favorable adiposity and lower risk of type 2 diabetes, hypertension and heart disease' Diabetes, vol 65, no. 8, pp. 2448-2460. DOI: 10.2337/db15-1671 Zhou, K, Yee, SW, Seiser, EL, van Leeuwen, N, Tavendale, R, Dujic, T, Logie, L, Sutherland, C, Palmer, CNA & Pearson, E 2016, 'Variation in the Glucose Transporter gene SLC2A2 is associated with glycaemic response to metformin' Nature Genetics. Zhou, K, Pedersen, HK, Dawed, AY & Pearson, ER 2016, 'Pharmacogenomics in diabetes mellitus: insights into drug action and drug discovery' Nature Reviews Endocrinology, vol 12, no. 6, pp. 337-46. DOI: 10.1038/nrendo.2016.51 Pearson, ER 2016, 'Personalized medicine in diabetes: The role of 'omics' and biomarkers' Diabetic Medicine, vol 33, no. 6, pp. 712-717. DOI: 10.1111/dme.13075 Dawed, AY, Donnelly, L, Tavendale, R, Carr, F, Leese, G, Palmer, CNA, Pearson, E & Zhou, K 2016, 'CYP2C8 and SLCO1B1 variants and therapeutic response to thiazolidinediones in patients with type 2 diabetes.' Diabetes Care. DOI: 10.2337/dc15-2464 Shepherd, M, Shields, B, Hammersley, S, Hudson, M, McDonald, TJ, Colclough, K, Oram, RA, Knight, B, Hyde, C, Cox, J, Mallam, K, Moudiotis, C, Smith, R, Fraser, B, Robertson, S, Greene, S, Ellard, S, Pearson, ER, Hattersley, AT & on behalf of the UNITED Team 2016, 'Systematic population screening, using biomarkers and genetic testing, identifies 2.5% of the U.K. pediatric diabetes population with monogenic diabetes' Diabetes Care. DOI: 10.2337/dc16-0645 Singh, JSS, Fathi, A, Vickneson, K, Mordi, I, Mohan, M, Houston, JG, Pearson, ER, Struthers, AD & Lang, CC 2016, 'Research into the effect Of SGLT2 inhibition on left ventricular remodelling in patients with heart failure and diabetes mellitus (REFORM) trial rationale and design' Cardiovascular Diabetology, vol 15, 97. DOI: 10.1186/s12933-016-0419-0 Oram, RA, McDonald, TJ, Shields, BM, Hudson, MM, Shepherd, MH, Hammersley, S, Pearson, ER, Hattersley, AT & on behalf of the UNITED Team 2015, 'Most people with long-duration type 1 diabetes in a large population-based study are insulin microsecretors' Diabetes Care, vol 38, no. 2, pp. 323-328. DOI: 10.2337/dc14-0871 Dujic, T, Zhou, K, Donnelly, LA, Tavendale, R, Palmer, CNA & Pearson, ER 2015, 'Association of organic cation transporter 1 with intolerance to metformin in Type 2 diabetes: a GoDARTS study' Diabetes, vol 64, no. 5, pp. 1786-1793. DOI: 10.2337/db14-1388 Yew, TW, McCreight, L, Colclough, K, Ellard, S & Pearson, ER 2015, 'tRNA methyltransferase homologue gene TRMT10A mutation in young adult-onset diabetes with intellectual disability, microcephaly and epilepsy' Diabetic Medicine. DOI: 10.1111/dme.13024 Pearson, ER 2015, 'Dissecting the etiology of type 2 diabetes in the Pima Indian population' Diabetes, vol 64, no. 12, pp. 3993-3995. DOI: 10.2337/dbi15-0016