McLean, Irwin 照片

McLean, Irwin

Professor

所属大学: University of Dundee

所属学院: School of Life Sciences

邮箱:
w.h.i.mclean@dundee.ac.uk

个人主页:
http://www.lifesci.dundee.ac.uk/people/irwin-mclean

近期论文

Smith FJD et al., Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris. Nature Genetics 38:337-342 (2006). Palmer CNA et al., Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nature Genetics 38:441-446 (2006). Sandilands A et al., Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema. Nature Genetics 39:650-654 (2007). Fallon PG et al., A homozygous frameshift mutation in the murine filaggrin gene facilitates enhanced percutaneous allergen priming. Nature Genetics 41:602-608 (2009). Leachman SA et al., First-in-human Mutation-targeted siRNA Phase Ib Trial of an Inherited Skin Disorder. Molecular Therapy 8:442-446 (2010). Irvine AD, McLean WHI, Leung DY (2011) Filaggrin mutations associated with skin and allergic diseases. N Engl J Med 365: 1315-1327 (PubMed ID: 21991953) Brown SJ et al., Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy. J Allergy Clin Immunol 127:661-667 (2011). Zhao Y et al., Statins downregulate K6a promoter activity: a possible therapeutic avenue for pachyonychia congenita. J Invest Dermatol 131:1045-1052 (2011). Pohler E et al., (2012) Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma. Nature Genetics 44: 1272-1276