MacKintosh, Carol
Professor
所属大学: University of Dundee
所属学院: School of Life Sciences
个人主页:
http://www.lifesci.dundee.ac.uk/people/carol-mackintosh
近期论文
Chen Q, Xie B, Zhu S, Rong P, Sheng Y, Ducommun S, Chen L, Quan C, Li M, Sakamoto K, MacKintosh C, Chen S, Wang HY. A Tbc1d1 (Ser231Ala)-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice. Diabetologia. 2016 Nov 8. PubMed PMID: 27826658. Chen L, Chen Q, Xie B, Quan C, Sheng Y, Zhu S, Rong P, Zhou S, Sakamoto K, MacKintosh C, Wang HY, Chen S. Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion. Proc Natl Acad Sci U S A. (2016) Jun 28;113(26):7219-24. doi: 10.1073/pnas.1600581113. Epub 2016 Jun 15. PMID: 27307439 Ross, F. A., MacKintosh, C. and Hardie, D. G. (2016) AMP-activated protein kinase: a cellular energy sensor that comes in twelve flavours. The FEBS journald.o.i 10.1111/febs.13698Pubmed: PMC: 26934201 Hoxhaj, G., Caddye, E., Najafov, A., Houde, V. P., Johnson, C., Dissanayake, K., Toth, R., Campbell, D. G., Prescott, A. R. and MacKintosh, C. (2016) The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids. eLife. 5d.o.i 10.7554/eLife.12278Pubmed: 4889327PMC: 27244671 Madeira, F., Tinti, M., Murugesan, G., Cole, C., Berrett, E., MacKintosh, C. and Barton, G. J. (2015) 14-3-3-Pred: Improved methods to predict 14-3-3-binding phosphopeptides. Bioinformatics 2015;?doi: 10.1093/bioinformatics/btv133 [25735772] Ohman T, Soderholm S, Hintsanen P, Valimaki E, Lietzen N, MacKintosh C, Aittokallio T, Matikainen S, Nyman TA. (2014) Phosphoproteomics Combined with Quantitative 14-3-3-affinity Capture Identifies SIRT1 and RAI as Novel Regulators of Cytosolic dsRNA Recognition Pathway. Mol Cell Proteomics. 2014 Jul 5. pii: mcp.M114.038968. [24997996] Tinti M, Dissanayake K, Synowsky S, Albergante L, MacKintosh C. (2014) Identification of 2R-ohnologue gene families displaying the same mutation-load skew in multiple cancers. Open Biol 4, 140029. [read online] Chen Q, Quan C, Xie B, Chen L, Zhou S, Toth R, Campbell DG, Lu S, Shirakawa R, Horiuchi H, Li C, Yang Z, MacKintosh C, Wang HY, Chen S. (2014) GARNL1, a major RalGAP α subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins. Cell Signal 26, 1636-1648 [24768767] Tinti M, Madeira F, Murugesan G, Hoxhaj G, Toth R, MacKintosh C. (2014) ANIA: ANnotation and Integrated Analysis of the 14-3-3 interactome. doi: 10.1093/database/bat085 [24501395] Hoxhaj G, Dissanayake K, MacKintosh C. (2013) Effect of IRS4 Levels on PI 3-Kinase Signalling. PLoS One. 8, e73327. [24039912] Wang H.Y., Ducommun, S., Quan, C., Xie, B., Li, M., Wasserman, D.H., Sakamoto, K., MacKintosh, C. and Chen, S. (2013) AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues. Biochem J. 449, 479-489. [23078342] Hoxhaj G, Najafov A, Toth R, Campbell DG, Prescott AR, MacKintosh C. (2012) ZNRF2 is released from membranes by growth factors and with ZNRF1 regulates the Na+/K+ATPase. J Cell Sci 125, 4662-4675. [22797923] Tinti M, Johnson C, Toth R, Ferrier DEK, MacKintosh C. (2012) Evolution of signal multiplexing by 14-3-3-binding 2R-ohnologue protein families in the vertebrates. Open Biol 2, 120103. [Read online] Neukamm SS, Toth R, Morrice NA, Campbell DG, MacKintosh C, Lehmann R, H?ring H-U, Schleicher ED, Weigert C. (2012) Identification of the aminoacids 300-600 of IRS-2 as a 14-3-3 binding region with the importance of IGF-1/insulin regulated phosphorylation of Ser-573. PLoS ONE 7, e43296. [22912850] Ducommun S, Wang HY, Sakamoto K, MacKintosh C, Chen S. (2012) Thr649Ala-AS160 knock-in mutation does not impair contraction/AICAR-induced glucose transport in mouse muscle. Am J Physiol Endocrinol Metab 302, E1036-1043. [22318952] Chen S, Synowsky S, Tinti M, MacKintosh C. (2011) The capture of phosphoproteins by 14-3-3 proteins mediates actions of insulin. Trends Endocrinol Metab. 22, 429-436. [21871813] Johnson C, Tinti M, Wood NT, Campbell DG, Toth R, Dubois F, Geraghty KM, Wong BHC, Brown LJ, Tyler J, Gernez A, Chen S, Synowsky S, MacKintosh C. (2011) Visualization and biochemical analyses of the emerging mammalian 14-3-3-phosphoproteome. Mol Cell Proteomics M110.005751. [21725060] Dissanayake K, Toth R, Blakey J, Olsson O, Campbell DG, Prescott A, MacKintosh C. (2011) Regulation of human capicúa by Erk/p90RSK/14-3-3 signalling impacts on expression of PEA3 Ets transcription factors. Biochem J 433, 515-525. [21087211] Chen S, Wasserman DH, MacKintosh C, Sakamoto K. (2011) Mice with Thr649Ala-TBC1D4(AS160) knock-in mutation are insulin resistant with impaired glucose tolerance and altered GLUT4 trafficking. Cell Metab 13, 68-79. [21195350] Pozuelo Rubio M, Leslie NR, Murphy J, MacKintosh C. (2010) Mechanism of activation of PKB/Akt by the protein phosphatase inhibitor calyculin A. Cell Biochem Biophys 58, 147-156. [20717744] Johnson C, Crowther S, Stafford M, Campbell DG, Toth R, MacKintosh, C. (2010) Bioinformatic and experimental survey of 14-3-3 binding sites. Biochem J 427, 69-78. [20141511] Chen S, MacKintosh C. (2009) Differential regulation of NHE1 phosphorylation and glucose uptake by inhibitors of the ERK pathway and p90RSK in 3T3-L1 adipocytes. Cell Signal 21, 1984-1993. [19765648] Dubois F, Vandermoere F, Gernez A, Murphy J, Toth R, Chen S, Geraghty KM, Morrice NA, MacKintosh C. (2009) Differential 14-3-3-affinity capture reveals new downstream targets of PI 3-kinase signalling. Mol Cell Proteomics 8, 2487-2499. [19648646] Pehm?ller C, Treebak JT, Birk JB, Chen S, MacKintosh C, Hardie DG, Richter EA, Wojtaszewski J. (2009) Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle. Am J Physiol 297, E665-675. [19531644] Hunter RW, MacKintosh C, Hers I. (2009) Protein kinase C-mediated phosphorylation and activation of PDE3A regulates cAMP levels in human platelets. J Biol Chem 284, 12339-12348. [19261611] Treebak JT, Fr?sig C, Pehm?ller C, Chen S, Maarbjerg SJ, Brandt N, MacKintosh C, Zierath JR, Hardie DG, Kiens B, Richter EA, Wojtaszewski, JFP. (2009) Potential role of TBC1D4 in enhanced post-exercise insulin sensitivity in human skeletal muscle. Diabetologia 52, 891-900. [19252894] Wood NT, Meek DW, MacKintosh, C. (2009) 14-3-3 binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2 – potential interplay with the PKB/Akt pathway and p14ARF. FEBS Lett 583, 615-620. [19166854] Chen S, Murphy J, Toth R, Campbell DG, Morrice NA, MacKintosh C. (2008) Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators. Biochem J 409, 449-459. [17995453]