Following appointment as Consultant Dermatologist at the Royal London Hospital in 1983 Professor Leigh established the Centre for Cutaneous Research at Barts and The London School of Medicine and Dentistry, Queen Mary University of London (BLSMD) which developed into the premier research centre in skin biology and disease in UK and arguably Europe. During this period she became Professor of Dermatology (1992), Professor of Cell and Molecular Medicine (1999), Research Dean (1997-2002), Joint Research Director (2002-5), Dean for e-learning (2005-6). She was appointed Head of College and Vice Principal of Dundee University in November 2006 and re‑established a research laboratory in Dundee including the CR-UK Skin Tumour Laboratory. She was President of the Association of Physicians of UK and Ireland in 2010-11 and a council member of the Academy Medical Sciences 2009-12. She organised IID2013 in Edinburgh. She returned to full time research between Dundee, with programme grants from erc and CR-UK, and Lyon in Global Health with i-pri.. She serves on multiple grant giving bodies including the erc. She honoured with an OBE for services to medicine in 2006 and a CBE in 2012..She was awarded the Archiblad Gray medal of the British Association Dermatologists in 2012. She is a Trustee of Debra UK. She is a co-PI on a Wellcome Trust Strategic award for Dermatology and Genetic Medicine with Irwin McLean (2012-17) and is the Director of the Clinical network of DGEM: BADGEM.

Blaydon DC, Lind LK, Plagnol V, Linton KJ, Smith FJ, Wilson NJ, MLean WH, Munro CS, South AP, Leigh IM, O’Toole EA, Lundstrom, Kelsell DP. Mutations in AQP5, encodinga water- channel protein cause autosomal dominant diffuse non-epidermolytic plamoplantar keratoderma. AM J Hum Genet 2013 July. Kalk MJ, Ashworth T, Wnag H, Knoechel B, Mason EF, Morgan EA. Dorfman D, Pinkus G, Weigert O, Hornick JL, Chirieac LR, Hirsch M, Oh DJ, South AP, Leigh IM, Pourreyron C, Cassidy AJ, Deangelo DJ, Weinstock DM, Krop IE, Dillon D, Brock JE, Lazar AJ, Peto M, Cho RJ, Stoeck A, Haines BB, Sathayanrayanan S, Rodig S, Aster JC. PLOS One 2013 :*:e67306 Matin RN, Chikh A, Chong SL, Mesher D, Graf M, Sanza P, Sentore V, Scatolini M, Moretti F, Leigh IM, Proby CM, Costanzo A, Chiorino G, Cerio R, Harwood CA, Bergamaschi D. J Exp Med 2013 210:581-603 Lo Nigro C, Wang H, McHugh A, Lattanzio L, Matin R, Harwood C, Syed N, Hatzimichael E, Brisoulis E, Merlano M, Evans A, Thompson A, Leigh I, Fleming C, Inman GJ, Proby CM, Crook T. J Invest Dermatol 2013 :133:1278-85 Harwood CA, Mesher D, McGregor JM, Mitchell L, Leedham-Green M, Raftery M, Cerio R, Leigh IM, Proby CM. Am J Transplant 2013: 13: 199-29 Cheung BB, Koach J, Tan O, Kim P, Bell JL, D’andreti C, Sutton S, Malyukova A, Sekyere E, Norris M, Haber M, Kavallaris M, Cunningham AM, Proby CM, Leigh I, Willmott JS, Cooper CL, Halliday GM, Scolyer RA, Marshall GM. The retinoid signalling molecule TRIM 16 is repressed during squamous cell carcinoma skin carcinogenesis in vivo and reduces skin cancer cell migration in vitro. J Pathol 2012. 226:451-62 Blaydon DC, Etheridge SL, Risk JM, Hennies HC, Gay LJ, Carroll R, Plagnol V, McRonal FE, Stevens HP, Spurr NK, Bishop DT, Ellis A, Jankowski J, Field JK, Leigh IM, South AP, Kelsell DP. RHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome. Am J Hum Genet 2012 90: 340-6 Wang H, Lee S, Nigro CL, Lattanzio L, Merlano M, Monteverde M, Matin R, Purdie K, Mladkova N, Bergamaschi D, Harwood C, Syed N, Szlosarek P, Briasoulis E, McHugh A, Thompson A, Evans A, Leigh I, Fleming C, Inman GJ, Hatzimichael E, Proby CM, Crook T. NT5E(CD73)is epigenetically regulated in malignant melanoma and associated with metastatic site specificity. Br J Cancer 2012 e pub Bose A, Teh MT, Hutchinson IL, Wan H, Leigh IM, Waseem A. Two mechanisms regulate kertin K15 expression in keratinocytes: role of PKC/AP1 and FoxM1 mediated signalling. PLoS one 2012 &: e 38599 Hack K, Reilly L, Proby CM, Fleming C, Leigh I, Foerster J. Wnt 5a inhibits the CpG oligodeoxynucleotide- triggered activation of human plasmacytoid dendritic cells. Clin Exp Dermatol. 2012 37. 557-61 Ng YZ, Pourreyron C, Salas-Alanis JC, Dayal JH, Cepeda-Valdes R, Yan W, Wright S, Chen M, Fine JD, Hogg FJ, McGrath JA, Murrell DF, Leigh IM, Lane EB, South AP. Cancer Res 2012 72: 3522 3534 Robertson ED, Weir L, Romanowska M, Leigh IM, Panteleyev AA. Arnt controls the expression of epidermal differentiation genes through HDAC- and EGFR-dependent pathways. J Cell SCi 2012 April 14 e pub Lambert SR, Harwood CA, Purdie KJ, Gulati A, Matin RN, Romanowska M, Cerio R, Kelsell DP, Leigh IM, Proby CM. Metastatic cutaneous squamous cell carcinoma shows frequent deletion in the protein tyrosine phosphatise receptor Type D gene. Int J Cancer 2012 131 216-26