Stephen M. Keyse received a Bachelors degree in Pharmacy (BPharm Hons) at the University of Bath in 1978 and went on to obtain a Ph.D in Photobiology from that University in 1983. During postdoctoral training with Rex M. Tyrrell at the Swiss Institute for Experimental Cancer Research (ISREC) in Lausanne, he studied UV-induced DNA damage, repair and mutagenesis and developed an interest in the regulation of gene expression in response to conditions of oxidative-stress. Returning to the UK in 1989, this work was continued in the laboratory of Richard D. Wood at the ICRF (now CR-UK) Clare Hall Laboratories in London. In 1991 he was appointed as a group leader within the CR-UK Molecular Pharmacology Unit, then based at the University of Edinburgh. Since the relocation of the CR-UK unit to the University of Dundee in late 1992, he has been head of the CR-UK Stress Response Laboratory, first within the Biomedical Research Centre and now as part of the Cancer Research Division of the Medical Research Institute at Ninewells Hospital & Medical School. He was granted tenure by ICRF in 1996 and was awarded a personal chair at the University of Dundee in 2005.

Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-β Production. Niedzielska M, Raffi FA, Tel J, Muench S, Jozefowski K, Alati N, Lahl K, Mages J, Billmeier U, Schiemann M, Appelt UK, Wirtz S, Sparwasser T, Hochrein H, Figdor CG, Keyse SM, Lang R. J Immunol. 2015 Aug 15;195(4):1753-1762. Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expression. Rushworth LK, Kidger AM, Delavaine L, Stewart G, van Schelven S, Davidson J, Bryant CJ, Caddye E, East P, Caunt CJ, Keyse SM. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18267-18272. Free PMC Article Niedzielska, M; Bodendorfer, B; Munch, S; Eichner, A; Derigs, M; da Costa, O; Schweizer, A; Neff, F; Nitschke, L; Sparwasser, T; Keyse, SM; Lang, R; Gene Trap Mice Reveal an Essential Function of Dual Specificity Phosphatase Dusp16/MKP-7 in Perinatal Survival and Regulation of Toll-like Receptor (TLR)-induced Cytokine Production; Journal of Biological Chemistry; 2014 January 24; 289(4); 2112-2126. Dual-specificity MAP kinase phosphatases (MKPs): shaping the outcome of MAP kinase signalling. Caunt CJ, Keyse SM. FEBS J. 2013 Jan;280(2):489-504. Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways. Dickinson RJ, Delavaine L, Cejudo-Marín R, Stewart G, Staples CJ, Didmon MP, Trinidad AG, Alonso A, Pulido R, Keyse SM. J Biol Chem. 2011 286: 38018-26 Cross-talk between the p38alpha and JNK MAPK pathways mediated by MAP kinase phosphatase-1 determines cellular sensitivity to UV radiation. Staples CJ, Owens DM, Maier JV, Cato AC, Keyse SM. J Biol Chem. 2010 285: 25928-40. Dual-specificity MAP kinase phosphatases (MKPs) and cancer. Keyse SM.Cancer Metastasis Rev. 2008 27: 253-61. Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter. Ekerot M, Stavridis MP, Delavaine L, Mitchell MP, Staples C, Owens DM, Keenan ID, Dickinson RJ, Storey KG, Keyse SM. Biochem J. 2008 412:287-98 Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases. Owens DM, Keyse SM. Oncogene. 2007 26: 3203-13 Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases. Fox GC, Shafiq M, Briggs DC, Knowles PP, Collister M, Didmon MJ, Makrantoni V, Dickinson RJ, Hanrahan S, Totty N, Stark MJ, Keyse SM, McDonald NQ. Nature. 2007 447: 487-92 Diverse physiological functions for dual-specificity MAP kinase phosphatases.Dickinson RJ, Keyse SM. J Cell Sci. 2006 Nov 15;119(Pt 22):4607-15. The dual-specificity protein phosphatase DUSP9/MKP-4 is essential for placental function but is not required for normal embryonic development. Christie GR, Williams DJ, Macisaac F, Dickinson RJ, Rosewell I, Keyse SM. Mol Cell Biol. 2005 25: 8323-33. Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5. Mandl M, Slack DN, Keyse SM. Mol Cell Biol. 2005 25:1830-45