Harvey, Jenni
Dr
所属大学: University of Dundee
所属学院: School of Medicine
个人主页:
http://medicine.dundee.ac.uk/staff-member/dr-jenni-harvey
个人简介
Jenni Harvey obtained a BSc honours degree in Pharmacology at the University of Edinburgh (1990) before receiving a Ph.D. in 1993 for work on metabotropic glutamate receptors and synaptic transmission under the supervision of Graham Collingridge (University of Birmingham). She then undertook postdoctoral research positions with Dr Mike Lacey (University of Birmingham) and Prof Mike Ashford (University of Aberdeen) before moving to Dundee to set up her own laboratory after being awarded a Wellcome Research Career Development Fellowship (2001). In 2005, she was awarded a Wellcome University Award to continue her studies into the role of leptin in hippocampal synaptic function
研究领域
Leptin regulation of hippocampal excitatory synaptic transmission and synaptic plasticity in health and disease. Leptin and the aging brain. Leptin: a potential therapy in neurodegenerative disorders. The role of leptin in neuropsychiatric disorders. Estrogen and its role as a cognitive enhancer
近期论文
McGregor G, Malekizadeh Y, Harvey J. (2015) Food for thought: Regulation of synaptic function by metabolic hormones. Mol. Endocrinol. 29(1):3-13 Luo X, McGregor G, Irving AJ, Harvey J. (2015). Leptin Induces a Novel Form of NMDA Receptor-Dependent LTP at Hippocampal Temporoammonic-CA1 Synapses. eNeuro May 2015, 2 (3) DOI: 10.1523/ENEURO.0007-15.2015 Palmer MJ, Harvey J (2014). Honeybee Kenyon cells are regulated by a tonic GABA receptor conductance. J Neurophysiol. 112:2026-35. Harvey J (2014). Leptin and Alzheimer’s disease. in Diet and Nutrition in Dementia and Cognitive Decline (edited by Martin CR and Preedy VR). Irving AJ, Harvey J. (2014). Leptin regulation of hippocampal synaptic function in health and disease. Philosophical Transactions of The Royal Society B-Biological Sciences Vol 369 Issue 1633 Art No20130155 doi: 10.1098/rstb.2013.0155 Harvey J. (2013). Leptin regulation of neuronal morphology and hippocampal synaptic function. Front Synaptic Neurosci. 2013 Aug 6;5:3. Palmer MJ, Moffat C, Saranzewa N, Harvey J, Wright GA, Connolly CN. (2012). Cholinergic pesticides cause mushroom body neuronal inactivation in honeybees. Nat. Commun. 2013;4:1634. Doherty GH, Beccano-Kelly D, Yan SD, Gunn-Moore FJ, Harvey J. Leptin prevents hippocampal synaptic disruption and neuronal cell death induced by amyloid β. Neurobiology of Aging (2012) 34(1):226-37. Blair PR & Harvey J. PTEN: a new player controlling structural and functional synaptic plasticity. J. Physiol (2012). 590 (Pt 5):1017. Beccano-Kelly D, Harvey J. (2012). Leptin: a novel therapeutic target in Alzheimer's disease? Int J Alzheimers Dis. 2012; 2012:594137. Moult PR, Harvey J. (2011). NMDA receptor subunit composition determines the polarity of leptin-induced synaptic plasticity. Neuropharmacol. 61(5-6), 924-36. Moult PR, Cross A, Santos SD, Carvalho AL, Lindsay Y, Connolly CN, Irving AJ, Leslie NR, Harvey J. (2010). Leptin regulates AMPA receptor trafficking via PTEN inhibition. J. Neurosci. 30(11), 4088-101. Solovyova N, Moult PR, Milojkovic B, Lambert JJ, Harvey J. (2009). Bi-directional modulation of fast inhibitory synaptic transmission by leptin. J. Neurochem. 108(1), 190-201. Moult PR, Milojkovic B, Harvey J. (2009). Leptin reverses long-term potentiation at hippocampal CA1 synapses. J. Neurochem. 108, 685-96. Moult PR & Harvey J (2008). Hormonal regulation of hippocampal dendritic morphology and synaptic plasticity. Cell Adhesion and Migration 2(4):269-75. Doherty GH, Oldreive C & Harvey J (2008) Neuroprotective actions of leptin on central and peripheral neurons in vitro. Neurosci. 154, 1297-307. O’Malley D, MacDonald N, Mizielinska S, Connolly CN, Irving AJ & Harvey J. (2007). Leptin promotes rapid dynamic changes in hippocampal dendritic morphology. Mol. Cell. Neurosci. 35, 559-72. Harvey J. (2007). Leptin regulation of neuronal excitability and cognitive function. Curr. Opin. Pharmacol. 7, 643-647. Harvey J. (2007). Leptin: a diverse regulator of neuronal function. J. Neurochem. 100, 307-313. Harvey J, Shanley LJ, O’Malley D & Irving AJ (2005). Leptin: a potential cognitive enhancer? Biochem. Soc. Trans. 33, 1029-32.