Hardie, Grahame
Professor
所属大学: University of Dundee
所属学院: School of Life Sciences
近期论文
Hawley, S. A., Ford, R. J., Smith, B. K., Gowans, G. J., Mancini, S. J., Pitt, R. D., Day, E. A., Salt, I. P., Steinberg, G. R. and Hardie, D. G. (2016) The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels. Diabetes. 65, 2784-2794d.o.i 10.2337/db16-0058PMC: 27381369 Ross, F. A., Jensen, T. E. and Hardie, D. G. (2016) Differential regulation by AMP and ADP of AMPK complexes containing different gamma subunit isoforms. The Biochemical journal. 473, 189-199d.o.i 10.1042/BJ20150910Pubmed: 4700476PMC: 26542978 Fogarty, S., Ross, F. A., Vara Ciruelos, D., Gray, A., Gowans, G. J. and Hardie, D. G. (2016) AMPK Causes Cell Cycle Arrest in LKB1-Deficient Cells via Activation of CAMKK2. Molecular cancer research : MCR. 14, 683-695d.o.i 10.1158/1541-7786.MCR-15-0479PMC: 27141100 Ross, F. A., MacKintosh, C. and Hardie, D. G. (2016) AMP-activated protein kinase: a cellular energy sensor that comes in twelve flavours. The FEBS journald.o.i 10.1111/febs.13698PMC: 26934201 Hardie, D. G., Schaffer, B. E. and Brunet, A. (2016) AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs. Trends in cell biology. 26, 190-201d.o.i 10.1016/j.tcb.2015.10.013PMC: 26616193 Hardie, D. G. (2015) Molecular Pathways: Is AMPK a Friend or a Foe in Cancer? Clinical cancer research : an official journal of the American Association for Cancer Research. 21, 3836-3840d.o.i 10.1158/1078-0432.CCR-14-3300Pubmed: 4558946PMC: 26152739 Gowans, G. J., Hawley, S. A., Ross, F. A. and Hardie, D. G. (2013) AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation. Cell metabolism. 18, 556-566d.o.i 10.1016/j.cmet.2013.08.019Pubmed: 3791399PMC: 24093679 Hardie, D. G. and Alessi, D. R. (2013) LKB1 and AMPK and the cancer-metabolism link - ten years after. BMC biology. 11, 36d.o.i 10.1186/1741-7007-11-36Pubmed: 3626889PMC: 23587167 O'Neill, L. A. and Hardie, D. G. (2013) Metabolism of inflammation limited by AMPK and pseudo-starvation. Nature. 493, 346-355d.o.i 10.1038/nature11862PMC: 23325217 Hawley, S. A., Fullerton, M. D., Ross, F. A., Schertzer, J. D., Chevtzoff, C., Walker, K. J., Peggie, M. W., Zibrova, D., Green, K. A., Mustard, K. J., Kemp, B. E., Sakamoto, K., Steinberg, G. R. and Hardie, D. G. (2012) The ancient drug salicylate directly activates AMP-activated protein kinase. Science. 336, 918-922d.o.i 10.1126/science.1215327Pubmed: 3399766PMC: 22517326