Identification of Novel Inhibitors of the Type I Interferon Induction Pathway Using Cell-Based High-Throughput Screening. Zoe O. Gage, Z.O, Vasoul, A., Gray, D.W., Randall, R.E. and Adamson, C.S. Journal of Biomolecular Screening 2016 doi 10.1177/1087057116656314. Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity. Nühs, A., De Rycker, M., Manthri, S., Comer, E., Scherer, C.A., Schreiber, S.L., Ioset J., and Gray, D.W. PLoS Negl Trop Dis. 2015 Sep; 9(9): e0004094. New Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource. Imanol Pe?a, M Pilar Manzano, Juan Cantizani, Albane Kessler, Julio Alonso-Padilla, Ana I Bardera, Emilio Alvarez, Gonzalo Colmenarejo, Ignacio Cotillo, Irene Roquero, Vanessa Barroso, Ana Rodriguez, David W Gray, Miguel Navarro, Vinod Kumar, Alexander Sherstnev, David H Drewry, James R Brown, Jose M Fiandor, J Julio Martin. Scientific Reports 03/2015; 5:8771. DOI:10.1038/srep08771 Identification of Small Molecule Inhibitors of Pre-mRNA Splicing. Andrea Pawellek, Stuart McElroy, Timur Samatov, Lee Mitchell, Andrew Woodland, Ursula Ryder, David Gray, Reinhard Lührmann, Angus I Lamond. Journal of Biological Chemistry 10/2014; 290(10). DOI:10.1074/jbc.M114.590976 High throughput chemical screening for anti-virulence developmental phenotypes in Trypanosoma brucei. Macgregor, P., Ivens, A., Shave, S., Collie, I., Gray, D., Auer, M., Matthews, K. R. Jan-2014 In: Eukaryotic cell doi 10.1128/EC.00335-13 Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay. De Rycker, M., Hallyburton, I., Thomas, J., Campbell, L., Wyllie, S., Joshi, D., Cameron, S., Gilbert, I. H., Wyatt, P. G., Frearson, J. A., Fairlamb, A. H. & Gray, D. W. Jul-2013 In : Antimicrobial Agents and Chemotherapy. 57, 7, p. 2913-2922, 10 p. Discovery of an allosteric inhibitor binding site in 3-oxo-acyl-ACP reductase from Pseudomonas aeruginosa. Cukier, C. D., Hope, A. G., Elamin, A. A., Moynie, L., Schnell, R., Schach, S., Kneuper, H., Singh, M., Naismith, J. H., Lindqvist, Y., Gray, D. W., Schneider, G.Seo-2013 In: ACS Chemical Biology, 8, (11), 2518-27 A static-cidal assay for Trypanosoma brucei to aid hit prioritisation for progression into drug discovery programmes. De Rycker, M., O'Neill, S., Joshi, D., Campbell, L., Gray, D. W. & Fairlamb, A. H. 29-Nov-2012 In : PLoS Neglected Tropical Diseases. 6, 11, p. e1932 Allosteric competitive inhibitors of the glucose-1-phosphate Thymidylyltransferase (RmlA) from Pseudomonas aeruginosa. Alphey, M. S., Pirrie, L., Torrie, L. S., Boulkeroua, W. A., Gardiner, M., Sarkar, A., Maringer, M., Oehlmann, W., Brenk, R., Scherman, M. S., McNeil, M., Rejzek, M., Field, R. A., Singh, M., Gray, D., Westwood, N. J. & Naismith, J. H. 2013 In : ACS Chemical Biology, 8, (2), 387-96 Assessment of pseudomonas aeruginosa N-5,N-10-methylenetetrahydrofolate dehydrogenase - cyclohydrolase as a potential antibacterial drug target. Eadsforth, T. C., Gardiner, M., Maluf, F. V., McElroy, S., James, D., Frearson, J., Gray, D. & Hunter, W. N. 2012 In : PLoS ONE. 7, 4, p. -, 11 p., e35973 The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist. Rimland, J., Dunne, A., Hunjan, S. S., Sasse, R., Uings, I., Montanari, D., Caivano, M., Shah, P., Standing, D., Gray, D., Brown, D., Cairns, W., Trump, R., Smith, P. W., Bertheleme, N., D'Alessandro, P., Gul, S., Vimal, M., Smith, D. N. & Watson, S. P. Apr-2010 In : Bioorganic & Medicinal Chemistry Letters. 20, 7, p. 2340-3, 4 p. Synthesis of 3-alkyl naphthalenes as novel estrogen receptor ligands. Fang, J., Akwabi-Ameyaw, A., Britton, J. E., Katamreddy, S. R., Navas III, F., Miller, A. B., Williams, S. P., Gray, D. W., Orband-Miller, L. A., Shearin, J. & Heyer, D. 15-Sep-2008 In : Bioorganic & Medicinal Chemistry Letters. 18, 18, p. 5075-5077, 3 p. Design and synthesis of an array of selective androgen receptor modulators. Trump, R. P., Blanc, J-B. E., Stewart, E. L., Brown, P. J., Caivano, M., Gray, D. W., Hoekstra, W. J., Willson, T. M., Han, B. & Turnbull, P. 2007 In : Journal of Combinatorial Chemistry. 9, 1, p. 107-14, 8 p. Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory disease. Salter, M., Biggadike, K., Matthews, J. L., West, M. R., Haase, M. V., Farrow, S. N., Uings, I. J. & Gray, D. W. 2007 In : American Journal of Physiology: Lung Cellular and Molecular Physiology. 293, 3, p. L660-7, 8 p.