Gilbert, Ian 照片

Gilbert, Ian

Professor

所属大学: University of Dundee

所属学院: School of Life Sciences

邮箱:
i.h.gilbert@dundee.ac.uk

个人主页:
http://www.lifesci.dundee.ac.uk/people/ian-gilbert

近期论文

From on-target to off-target activity: identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti-Trypanosoma brucei drug discovery lead molecules. Woodland, A.; Grimaldi, R.; Luksch, T.; Cleghorn, L. A.; Ojo, K. K.; Van Voorhis, W. C.; Brenk, R. Frearson, J. A.; Gilbert, I. H.; Wyatt, P. G. ChemMedChem, 2013, 8, 1127-1137. Discovery and structure-activity relationships of pyrrolone antimalarials. Murugesan, D.; Mital, A.; Kaiser, M.; Shackleford, D. M.; Morizzi, J.; Katneni, K.; Campbell, M.; Hudson, A.; Charman, S. A.; Yeates, C.; Gilbert, I. H. J. Med. Chem., 2013, 56, 2975-2990. Synthesis and Evaluation of α-Thymidine Analogues as Novel Antimalarials. Cui, H.; Carrero-Lérida, J.; Silva, A. P.; Whittingham, J. L.; Brannigan, J. A.; Ruiz-Pérez, L. M.; Read, K. D.; Wilson, K. S.; González-Pacanowska, D.; Gilbert, I. H. J. Med. Chem., 2012, 55, 10948-10957. Automated design of ligands to polypharmacological profiles. Besnard, J.; Ruda, G. F.; Setola, V.; Abecassis, K.; Rodriguiz, R. M.; Huang, X. P.; Norval, S.; Sassano, M. F.; Shin, A. I.; Webster, L. A.; Simeons, F. R.; Stojanovski, L.; Prat, A.; Seidah, N. G.; Constam, D. B.; Bickerton, G. R.; Read, K. D.; Wetsel, W. C.; Gilbert, I. H.; Roth, B. L.; Hopkins, A. L. Nature, 2012, 492, 215-220. Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors. Spinks, D.; Torrie, L. S.; Thompson, S.; Harrison, J. R.; Frearson, J. A.; Read, K. D.; Fairlamb, A. H.; Wyatt, P. G.; Gilbert, I. H. ChemMedChem, 2012, 7, 95-106. Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors. Brand, S.; Cleghorn, L. A. T.; McElroy, S. P.; Robinson, D. A.; Smith, V. C.; Hallyburton, I.; Harrison, J. R.; Norcross, N. R.; Norval, S.; Spinks, S.; Stojanovski, L.; Torrie, L. S.; Frearson, J. A.; Brenk, R.; Fairlamb, A. H.; Ferguson, M. A. J.; Read, K. D.; Wyatt, P. G.; Gilbert, I. H. J. Med. Chem. 2012, 55, 140-152.