Stewart Fleming graduated in Immunology (1978) and Medicine (1980) from the University of Glasgow. After junior hospital training posts in Glasgow he moved to a Clinical Lectureship in Pathology in the University of Southampton. While here he completed his thesis on the Cellular Differentiation in Renal Carcinoma which was awarded MD with Honours from the University of Glasgow (1988). He was gained Membership of the Royal College of Pathologists in 1987 and Fellowship (FRCPath) in 1997. He was awarded the Oakley Lecture of the Pathological Society of Great Britain and Ireland in 1991. He moved to Senior Lecturer then Reader in Pathology at the University of Edinburgh in 1988 until 2000. He was appointed to the Chair of Cellular and Molecular Pathology in the University of Dundee in 2001and Honorary Consultant Pathologist to NHS Tayside. He has been the Scottish Chairman and Executive Member of the Royal College of Pathologists, chair of the Research Committee of the Pathological Society and a member of both the WHO and International Society of Urological Pathologists committees for Renal cancer classification. He has recently been elected as Chairman of the British Association of Urological Pathologists. He has published over 130 peer reviewed articles, several textbook chapters and has edited Muir’s Textbook of Pathology (14th Edition)

Fleming S., Mayer NJ., Vlatkovic LJ., McLean J., McConachie M., Baty D. Signalling pathways in succinate dehydrogenase B associated renal carcinoma. Histopathology 2013 Aug 12. doi: 10.1111/his.12250. [Epub ahead of print] Srigley, J. et ISUP. The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. American Journal of Surgical Pathology, 2013, 37;1469–1489 Delahunt, B. et ISUP. The International Society of Urological Pathology (ISUP) Grading System for Renal Cell Carcinoma and Other Prognostic Parameters. American Journal of Surgical Pathology. 2013, 37; 1490–1504 Tan, P. H. et ISUP. Renal Tumors: Diagnostic and Prognostic Biomarkers. American Journal of Surgical Pathology., 2013,37; 1518–1531 Trpkov, K. et ISUP. Handling and Staging of Renal Cell Carcinoma: The International Society of Urological Pathology Consensus (ISUP) Conference Recommendations. American Journal of Surgical Pathology, 2013, 37; 1505–1517 Buckley, C., Nelson, R., Sharp, M., Fleming, S., Kenyon, C., Mullins, L., Steppan, D. & Mullins, J. Complementation of juxtaglomerular cell granulation in Ren- 1d null mice by human renin FASEB J, 2013 27:1165.20 Sandilands, A., Smith, F. J. D., Lunny, D. P., Campbell, L. E., Davidson, K. M., MacCallum, S. F., Corden, L. D., Christie, L., Fleming, S., Lane, E. B. & McLean, W. H. I. Generation and characterisation of keratin 7 (K7) knockout mice PLoS ONE. 8, 5, 11 p., e6440 Bambury RM, Battley JE, McCarthy A, Brady C, O'Reilly S, Kelly PJ, O'Brien F, Sweeney P, Fleming S, Mayer NJ, Power DG. Translocation Renal Cell Carcinomas: An Evolving Entity and a Member of the Microphthalmia Transcription Factor-Associated Family of Tumors. Clin Genitourin Cancer. 2013 11(3):357-61 Appleyard MV, Murray KE, Coates PJ, Wullschleger S, Bray SE, Kernohan NM, Fleming S, Alessi DR, Thompson AM. Phenformin as prophylaxis and therapy in breast cancer xenografts. Br J Cancer. 2012;106(6):1117-22 Berenjeno IM, Guillermet-Guibert J, Pearce W, Gray A, Fleming S, Vanhaesebroeck B. Both p110a and p110b isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor. Biochem J. 2012, 442 : 151-159 García-Martínez JM, Wullschleger S, Preston G, Guichard S, Fleming S, Alessi DR, Duce SL. Effect of PI3K- and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKB1-deficient mice. Br J Cancer. 2011;104(7):1116-25 Tummala H, Fleming S, Hocking PM.; The D153del Mutation in GNB3 Gene Causes Tissue Specific Signalling Patterns and an Abnormal Renal Morphology in Rge Chickens. PLOS ONE 2011 6;8 Article Number: e21156 DOI: 10.1371/journal.pone.0021156 Gill AJ, Pachter NS, Chou A, Young B, Clarkson A, Tucker KM, Winship IM, Earls P, Benn DE, Robinson BG, Fleming S, Clifton-Bligh RJ. Renal Tumors Associated With Germline SDHB Mutation Show Distinctive Morphology. American Journal of Surgical Pathology 2011 35;1578-1585 Miller G, Matthews S, Reinheckel T, Fleming S; Watts C. Asparagine endopeptidase is required for normal kidney physiology and homeostasis. FASEB Journal 2011 25: 1606-1617 Wullschleger S, Sakamoto K, Johnstone L, Duce S, Fleming S, Alessi DR. How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance. Dis Model Mech. 2011 Jan;4(1):95-103. Fleming S. Renal cell carcinoma in acquired cystic kidney disease. Histopathology. 2010 ;56(3):395-400 Rafiqi FH, Zuber AM, Glover M, Richardson C, Fleming S, Jovanovi? S, Jovanovi? A, O'Shaughnessy KM, Alessi DR. Role of the WNK-activated SPAK kinase in regulating blood pressure. EMBO Mol Med. 2010, 2; 63-75 Housley SL, Lindsay RS, Young B, McConachie M, Mechan D, Baty D, Christie L, Rahilly M, Qureshi K, Fleming S. Renal carcinoma with giant mitochondria associated with germ-line mutation and somatic loss of the succinate dehydrogenase B gene. Histopathology. 2010 ;56(3):405-8. Nobrega MA, Solberg Woods LC, Fleming S, Jacob HJ. (2009) Distinct genetic regulation of the progression of diabetes and renal disease in the Goto-Kakizaki (GK) rat. Physiol Genomics. 2009 ;39(1):38-46 Liu X, Bellamy CO, Bailey MA, Mullins LJ, Dunbar DR, Kenyon CJ, Brooker G, Kantachuvesiri S, Maratou K, Ashek A, Clark AF, Fleming S, Mullins JJ. (2009) Angiotensin-converting enzyme is a modifier of hypertensive end organ damage. J Biol Chem. 2009 Jun 5;284(23):15564-72. McQuarrie EP, Mackinnon B, Young B, Yeoman L, Stewart G, Fleming S, Robertson S, Simpson K, Fox J, Geddes CC; Scottish Renal Biopsy Registry (2009) Centre variation in incidence, indication and diagnosis of adult native renal biopsy in Scotland. Nephrol Dial Transplant. 2009 May;24(5):1524-8. Hadad SM, Baker L, Quinlan PR, Robertson KE, Bray SE, Thomson G, Kellock D, Jordan LB, Purdie CA, Hardie DG, Fleming S, Thompson AM. Histological evaluation of AMPK signalling in primary breast cancer. BMC Cancer. 2009;9:307. Clark EL, Coulson A, Dalgliesh C, Rajan P, Nicol SM, Fleming S, Heer R, Gaughan L, Leung HY, Elliott DJ, Fuller-Pace FV, Robson CN. (2008) The RNA helicase p68 is a novel androgen receptor coactivator involved in splicing and is overexpressed in prostate cancer. Cancer Res. 2008 Oct 1;68(19):7938-46 Hadad SM, Fleming S, Thompson AM. Targeting AMPK: a new therapeutic opportunity in breast cancer. Crit Rev Oncol Hematol. 2008 Jul;67(1):1-7 Huang X, Wullschleger S, Shapiro N, McGuire VA, Sakamoto K, Woods YL, McBurnie W, Fleming S, Alessi DR (2008) Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. Biochem J. 2008 Jun 1;412(2):211-21