Ferguson, Mike
Professor
近期论文
Ryan, C. M., Mehlert, A., Richardson, J.M., Ferguson, M.A.J.*, Johnson, P.J.* (2011). Chemical structure of Trichomonas vaginalis surface lipoglycan: a role for short galactose (b1-4/3) N-acetylglucosamine repeats in host cell interaction. J. Biol. Chem. 286, 40494-40508. *Joint senior authors. Mehlert, A., Wormald, M.R. and Ferguson, M.A.J. (2012) Modeling of the N-glycosylated transferrin receptor suggests how transferrin binding can occur within the surface coat ofTrypanosoma brucei. PLoS Pathogens 8, e1002618. Allen, S., Richardson, J.M., Mehlert, A and Ferguson, M.A.J. (2013) Structure of a complex phosphoglycan epitope from gp72 of Trypanosoma cruzi. J. Biol. Chem. 288, 11093-11105. Izquierdo, L., Nakanishi, M, Mehlert, A., Machray, G., Barton, G.J. and Ferguson, M.A.J. (2009) Identification of a GPI-anchor modifying β1-3 N-acetylglucosaminyltransferase in Trypanosoma brucei. Mol. Microbiol. 71, 478-491 Izquierdo, L., Schulza, B.L., Rodrigues, J.A., Güther, M.L.S., Proctor, J.B., Barton, G.J., Aebi, M. and Ferguson, M.A.J. (2009) Distinct oligosaccharide donor and peptide acceptor specificities of Trypansosoma brucei oligosaccharyltransferases. EMBO J. 28, 2650-2661. Güther, M.L.S., Beattie, K., Lamont, D.J., James, J., Prescott, A.R. and Ferguson, M.A.J. (2009) The fate of GPI-less procyclin and characterisation of sialylated non-GPI anchored surface coat molecules of procyclic form Trypanosoma brucei. Eukaryotic Cell, 8, 1407-1417. Marino, K., Güther, M.L., Wernimont, A., Amani, M., Hui, R. and Ferguson, M.A.J. (2010) Identification, subcellular localization, biochemical properties and high-resolution crystal structure of Trypanosoma brucei UDP-glucose pyrophosphorylase. Glycobiology, 12, 1619-1630. Mari?o, K.M.L., Güther, M.L., Wernimont, A.K., Hui, R., Ferguson, M.A. (2011) “Characterization, localization, essentiality and high-resolution crystal structure of Glucosamine 6-phosphate N-Acetyltranserase from Trypanosoma brucei”. Eukaryot. Cell 10 (7), 985-997 Keuttel, S., Wadum, M.C.T., Guther, M.L.S., Marino, K., Riemer, C. and Ferguson, M.A.J. (2012) The de novo and salvage pathways of GDP-mannose biosynthesis are both sufficient for the growth of bloodstream form Trypanosoma brucei. Mol. Microbiol. 84, 340-351. Bandini, G., Mari?o,K., Güther, M.L.S., Wernimont,A.K., Kuettel, S., Qiu, W., Afzal, S., Kelner, A., Hui, R. and Ferguson, M.A.J. (2012) Phosphoglucomutase is absent in Trypanosoma brucei and redundantly substituted by phosphomannomutase and phospho-N-acetylglucosamine mutase. Mol. Microbiol. 85, 513–534. Damerow, M., Rodrigues, J., Wu, D., Guther, M.L.S., Mehlert, A. and Ferguson, M.A.J. (2014) Identification and Functional Characterization of a highly divergent N-Acetylglucosaminyltransferase I (TbGnTI) in Trypanosoma brucei. J. Biol. Chem. 289, 9328-9339. Izquierdo, L. Acosta-Serrano, A., Mehlert, A. and Ferguson, M.A.J. (2015) Identification of a glycosylphosphatidylinositol anchor-modifying b1-3 galactosyltransferase in Trypanosoma brucei. Glycobiology, in press. Urbaniak, M., Guther, M.L.S. and Ferguson, M.A.J. (2012) Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages. PLoS One 7, e36619 Güther, M.L.S., Urbaniak, M.D., Tavendale, A. Prescott, A.P. and Ferguson, M.A.J. (2014) A high-confidence glycosome proteome for procyclic form Trypanosoma brucei by epitope-tag organelle enrichment and SILAC proteomics. J. Proteome Res, 13, 2796-2806 Nett, I.R.E., Martin, D.M.A., Miranda-Saavedra, D., Lamont, D.J., Barber, J.D., Mehlert, A. and Ferguson, M.A.J. (2009) The phosphoproteome of bloodstream form Trypanonosoma brucei, causative agent of African Sleeping Sickness. Mol. Cell. Proteomics 8, 1527-1538. Urbaniak, M.D., Martin, D.M.A. and Ferguson, M.A.J. (2013) Global quantitative SILAC phosphoproteomics reveals differential phosphorylation is widespread between the procyclic and bloodstream form lifecycle stages of Trypanosoma brucei. J. Proteome Res. 12, 2233?2244. Sizova, O. V., A. J. Ross, Ivanova, I. A., Borodkin, V. S., Ferguson, M. A. J., Nikolaev, A. V. (2011). "Probing Elongating and Branching beta-d-Galactosyltransferase Activities in Leishmania Parasites by Making Use of Synthetic Phosphoglycans." ACS Chem Biol 6 (6), 648-657 Urbaniak, M.D., Capes, A.S., Crossman, A., O’Neill, S., Thompson, S., Gilbert, I.H.*, Ferguson, M.A.J.* (2014) Fragment screening reveals salicylic hydroxamic acid as an inhibitor of Trypanosoma brucei GPI GlcNAc-PI de-N-acetylase. Carbohyd. Res. 387, 54-58. *joint corresponding authors Capes, A.S., Crossman, A., Urbaniak, M.D., Gilbert, S.H., Ferguson, M.A.J.* and Gilbert I.H.* (2014) Probing the substrate specificity of Trypanosoma brucei GPI GlcNAc-PI de-N-acetylase with synthetic substrate analogues. Organic & Biomolecular Chemistry 12, 1919-1934. *joint corresponding authors Urbaniak, M.D., Collie, I., Fang, W., Aristotelous, T., Eskilsson, S., Harrison, J., Hopkins-Navratilova, I., Frearson, J.A., van Aalten, D.M.F. and Ferguson, M.A.J. (2013) A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei. ACS Chemical Biology, 8, 1981-1987. Frearson, J.F., Brand,S., McElroy, S.P., Cleghorn, L.A.T., Smid, O., Stojanovski, L., Price, H.P., Guther, M.L.S., Torrie, L.S., Robinson, D.A., Hallyburton, I., Mpamhanga, C.P. Brannigan, J.A. Wilkinson, A.J., Hodgkinson, M. Hui, R., Qui, W. Raimi, O.G. van Aalten, D.M.F., Brenk, R., Gilbert, I.H., Read, K.D., Fairlamb, A.H.Ferguson, M.A.J., Smith, D.F. and Wyatt, P.G (2010) N-Myristoyltransferase inhibitors: new leads for the treatment of human African trypanosomiasis. Nature 464, 728-732 Atrih, A., Turnock, D., Sellar, G., Thompson, A., Feuerstein, G., Ferguson, M.A.J and Huang, J T-J (2010) Stoichiometric Quantification of Akt Phosphorylation using LC-MS/MS. J. Proteome Res. 9, 743-751. Sullivan, L., Wall, S., Carrington, M. and Ferguson, M.A.J. (2013) Proteomic selection of immunodiagnostic antigens for human African trypanosomiasis and generation of a prototype lateral flow immunodiagnostic device. PLoS Neglected Tropical Diseases 7, e2087 Fleming, J.R., Sastry, L., Crozier, T.W.M., Napier, G.B., Sullivan, L. and Ferguson, M.A.J. (2014) Proteomic selection of immunodiagnostic antigens for Trypanosoma congolense. PLoS Neglected Tropical Disease, in press Sullivan, L., Fleming, J. Sastry, L. Mehlert, A., Wall, S.J. and Ferguson, M.A.J. (2014) Identification of sVSG117 as an immunodiagnostic antigen and evaluation of a dual-antigen lateral flow test for the diagnosis of human African trypanosomiasis. PLoS Neglected Tropical Disease 8, e2976 Sternberg, J.M., Gierliński , M., Biéler, S., Ferguson, M.A.J. and Ndung'u, J.M. (2014) Evaluation of the diagnostic accuracy of prototype rapid tests for human African trypanosomiasis?. PLoS Neglected Tropical Disease e3373