Paul Clarke is Professor of Cancer Cell Biology and the Associate Dean for Research for the School of Medicine. He joined the University of Dundee as a Senior Lecturer in 1998 and was awarded a personal chair in 2005. He has been Research Coordinator for the Biomedical Research Centre (2002-2007) and Head of Research for the College of Medicine, Dentistry and Nursing (2007-2008). Previously he was at the University of Manchester (1994-1998) and was a research fellow in the group of E. Karsenti at the European Molecular Biology Laboratory, Heidelberg (1991-1994). As a student, he read Biochemistry at Bristol and carried out research for his PhD with D. G. Hardie at Dundee. Professor Clarke has received a Royal Society-Wolfson Research Merit Award (2003-2008) and research fellowships from The Wellcome Trust and Cancer Research UK. His research group is funded by Cancer Research UK, Association for International Cancer Research, Biotechnology and Biological Sciences Research Council, and Tenovus Scotland.

Wu Z, Jiang Q, Clarke PR, Zhang C. Phosphorylation of Crm1 by CDK1-cyclin-B promotes Ran-dependent mitotic spindle assembly. J Cell Sci. 2013 Aug 1;126(Pt 15):3417-28. doi: 10.1242/jcs.126854. Harley, M.E., Allan, L.A., Sanderson, H.S. and Clarke, P.R. (2010) Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent degradation during mitotic arrest. EMBO J 29, 2407-2020. Clarke, P.R., Allan, L.A., (2009) Cell-cycle control in the face of damage - a matter of life or death. Trends Cell Biol. 19, 89-98. Clarke, P.R., Zhang, C., (2008) Spatial and temporal coordination of mitosis by Ran GTPase. Nat. Rev. Mol. Cell. Biol. 9. 464-77. Seifert, A., Allan, L.A., Clarke, P.R. (2008) DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine. FEBS J. 275, 6268-80. Allan, L.A. and Clarke, P.R. (2007) Phosphorylation of caspase-9 by CDK1/cyclin B1 protects cells against apoptosis. Mol. Cell 26, 301-310. Brady, S.C., Allan, L.A. and Clarke, P.R. (2005) Regulation of caspase-9 through phosphorylation by protein kinase C zeta in response to hyperosmotic stress. Mol. Cell. Biol. 25, 10543-10555. Hutchins, J.R.A., Moore, W.J., Hood, F.E., Wilson, J.S.J., Andrews, P.D., Swedlow, J.R. and Clarke, P.R. (2004) Phosphorylation regulates the dynamic interaction of RCC1 with chromosomes during mitosis. Curr. Biol. 14, 1099-1104. Allan, L.A., Morrice, N, Brady, S., Magee, G., Pathak, S. and Clarke, P.R. (2003) Inhibition of caspase-9 by phosphorylation at Thr125 by ERK MAPK. Nature Cell Biol. 5, 647-654. Moore, W.J., Zhang, C. and Clarke, P.R. (2002) Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells. Curr. Biol. 12, 1442-1447. Zhang, C. and Clarke, P.R. (2000) Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts. Science 288, 1429-1432