Cardote, T.A.F., and Ciulli, A. Cyclic and macrocyclic peptides as chemical tools to recognise protein surfaces and probe protein-protein interactions. ChemMedChem, Publication Date (Web): Nov 13, 2015. DOI: 10.1002/cmdc.201500450(Read Online) Baud, M.G.J., Lin-Shiao, E., Zengerle, M., Tallant, C., and Ciulli A. New synthetic routes to triazolo-benzodiazepine analogues: expanding the scope of the bump-and-hole approach for selective BET bromodomain inhibition. J. Med. Chem., Article ASAP, Publication Date (Web): September 14, 2015. DOI: 10.1021/acs.jmedchem.5b01135(Read Online) Gadd, M.S., Bulatov, E. and Ciulli, A. Serendipitous SAD solution for DMSO-soaked SOCS2-ElonginC-ElonginB crystals using covalently incorporated dimethylarsenic: insights into substrate receptor conformational flexibility in Cullin RING ligases. Plos One 2015, June 29; 10(6):e013218(Read Online) Zengerle, M., Chan, K.-H., Ciulli, A. Selective small molecules induced degradation of the BET bromodomain protein BRD4. ACS Chem. Biol. 2015, 10(8), 1770-1888(Read Online) Bulatov, E., Ciulli, A. Targeting Cullin RING E3 ubiquitin ligases for drug discovery: structure, assembly and small molecule modulation. Biochem. J. 2015, 467(3), 365–386.(Read Online) Tallant, C., Valentini, E. Fedorov, O., Overvoorde, L., Ferguson, F.M., Filippakopoulos, P., Svergun, D.I., Knapp, S., Ciulli, A. Molecular basis of histone tail recognition by human TIP5 PHD finger and Bromodomain of the chromatin remodelling complex NoRC.Structure, 2015, 23 (1), 80-92 (Read Online) Bulatov, E., Martin, E.M., Chatterjee, S., Knebel, A., Shimamura, S., Konijnenberg, A., Johnson, C., Zinn, N., Grandi, P., Sobott, F., Ciulli, A. Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2):ElonginBC:Cullin5:RING-box protein 2 (Rbx2). J. Biol. Chem. 2015, 290(7) 4178-4198. [Epub ahead of print] (Read Online) Baud, M.G., Lin-Shiao, E., Cardote, T., Tallant, C., Pschibul, A., Chan, K.H., Zengerle, M., Garcia, J.R., Kwan, T.T., Ferguson, F.M., Ciulli, A. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes.Science 2014, 346 (6209), 638-641 (Read Online) Galdeano, C., Gadd, M.S., Soares, P., Scaffidi, S., Van Molle, I., Birced, I., Hewitt, S., Dias, D.M., Ciulli A. Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with In Vitro Nanomolar AffinitiesJ. Med Chem. 2014, 57 (20), 8657-8663. (Read Online) Dias, D.M., Van Molle, I., Baud, M.G.J., Galdeano, C., Geraldes, C.F.G.C., Ciulli, A. Is NMR Fragment Screening Fine-Tuned to Assess Druggability of Protein-Protein Interactions?ACS Med. Chem. Lett. 2014, 5 (1), 23-28. (Read Online) Thomas, J.C., Matak-Vinkovic, D., Van Molle, I., Ciulli, A. Multimeric Complexes among Ankyrin-Repeat and SOCS-box Protein 9 (ASB9), ElonginBC, and Cullin 5: Insights into the Structure and Assembly of ECS-type Cullin-RING E3 Ubiquitin Ligases. Biochemistry 2013, 52(31), 5236-5246. (Read online) Silvestre, H.L., Blundell, T.L., Abell, C., Ciulli, A. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery. Proc. Natl. Acad. Sci. U.S.A. 2013, 110(32), 12984-12989. (Read online) Ciulli, A. Biophysical Screening for the Discovery of Small-Molecule Ligands, in: ‘Protein-Ligand Interactions - Methods and Applications, 2nd Ed.’. T. Daviter and M. Williams, Ed., Springer Protocols, Humana Press. ISBN: 978-1-62703-397-8 Methods Mol Biol. 2013, vol. 1008, pp. 357-388. (Read online) Van Molle, I., Thomann, A., Buckley, D.L., So, E.C., Lang, S., Crews, C.M., Ciulli, A. Dissecting fragment-based lead discovery at the von-Hippel Lindau protein : Hypoxia Inducible Factor 1α protein-protein interface. Chem. Biol. 2012, 19, 1300-1312. (Read online)