Barratt, Christopher 照片

Barratt, Christopher

Professor

所属大学: University of Dundee

所属学院: School of Medicine

邮箱:
c.barratt@dundee.ac.uk

个人主页:
http://medicine.dundee.ac.uk/staff-member/professor-christopher-barratt

个人简介

Professor Barratt is Head of the Reproductive Medicine Group at the University of Dundee as well as a clinical scientist (Hon) with NHS Tayside. He graduated with an Honours degree in Zoology and then completed a Post Graduate Certificate in Education (University of Wales, Swansea). His PhD, also in Zoology, was under the supervision of Jack Cohen (sperm selection fame) at the University of Birmingham. His formative post-doctoral studies and IVF experience was gained at the University of Sheffield [with Ian Cooke] where they specialized in natural cycle IVF. From 1997-2005 he was the Scientific Director of the ART Centre at the Birmingham Women’s Hospital. In 2002 he was awarded Young Andrologist of the Year (American Andrology Society) for outstanding contributions to the discipline. He is a regularly invited speaker at national and international scientific conferences/workshops. He was a member of the WHO Male Fertility Semen Analysis Taskforce (for both the 4th and 5th editions) and is now director of the new WHO (2012-2016) Male Fertility Expert Working Group which is devising a new system for the diagnosis and treatment of the infertile male. He was a member of the Human Fertilisation and Embryology Authority for 6 years. He has been on the Editorial Board of Human Reproduction, Human Fertility, Biology of Reproduction, Human Reproduction Update and Journal of Andrology. In 2014 Professor Barratt presented the Professor Sir Robert Edwards keynote lecture at ESHRE. This presentation was based on the highest downloaded paper in Human Reproduction for 2013.

近期论文

Preimplantation genetic screening-23 years to navigate and translate into the clinical arena. We need a new roadmap! Barratt CL. Mol Hum Reprod. 2016 Jun 3. pii: gaw035. [Epub ahead of print] No abstract available. PMID:27260687 Depolarization of sperm membrane potential is a common feature of men with subfertility and is associated with low fertilization rate at IVF. Brown SG, Publicover SJ, Mansell SA, Lishko PV, Williams HL, Ramalingam M, Wilson SM, Barratt CL, Sutton KA, Da Silva SM.Hum Reprod. 2016 Jun;31(6):1147-57. doi: 10.1093/humrep/dew056. Epub 2016 Apr 6. PMID:27052499 'Single cell analysis in development' special series. Barratt CL. Mol Hum Reprod. 2016 Mar;22(3):159. 'How to count sperm properly': checklist for acceptability of studies based on human semen analysis. Bj?rndahl L, Barratt CL, Mortimer D, Jouannet P. Hum Reprod. 31,227-32. A spontaneous increase in intracellular Ca2+ in metaphase II human oocytes in vitro can be prevented by drugs targeting ATP-sensitive K+ channels. Fernandes G, Dasai N, Kozlova N, Mojadadi A, Gall M, Drew E, Barratt E, Madamidola OA, Brown SG, Milne AM, Martins da Silva SJ, Whalley KM, Barratt CL, Jovanovi? A. Hum Reprod. 2016 31, 287-97. Is there a robust future for research in reproduction? Barratt CL. Mol Hum Reprod. 2016 Jan;22(1):1-2. doi: 10.1093/molehr/gav062. Epub 2015 Nov 20. No abstract available. 22, 1-2. Specific loss of CatSper function is sufficient to compromise fertilizing capacity of human spermatozoa. Williams HL, Mansell S, Alasmari W, Brown SG, Wilson SM, Sutton KA, Miller MR, Lishko PV, Barratt CL, Publicover SJ, Martins da Silva S. Hum Reprod. 2015 30, 2737-46 Sperm selection in natural conception: what can we learn from Mother Nature to improve assisted reproduction outcomes? Sakkas D, Ramalingam M, Garrido N, Barratt CL. Hum Reprod Update. 2015 Nov;21(6):711-26. doi: 10.1093/humupd/dmv042. Epub 2015 Sep 19. Review. Total levels, localization patterns, and proportions of sperm exhibiting phospholipase C zeta are significantly correlated with fertilization rates after intracytoplasmic sperm injection.Yelumalai S, Yeste M, Jones C, Amdani SN, Kashir J, Mounce G, Da Silva SJ, Barratt CL, McVeigh E, Coward K. Fertil Steril. 2015 Sep;104(3):561-568.e4. doi: 10.1016/j.fertnstert.2015.05.018. Epub 2015 Jun 18. Dorin JR, Barratt CL. Importance of β-defensins in sperm function. Mol Hum Reprod. 2014 Sep;20(9):821-6. doi: 10.1093/molehr/gau050. Epub 2014 Jul 9. Review. Mansell SA, Publicover SJ, Barratt CL, Wilson SM. (2014) Patch clamp studies of human sperm under physiological ionic conditions reveals three functionally and pharmacologically distinct cation channels. Molecular Human Reproduction. 20:392-408. Tardif S, Madamidola OA, Brown SG, Frame L, Lefièvre L, Wyatt PG, Barratt CL, Martins Da Silva SJ. Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity. Hum Reprod. 2014 Oct 10;29(10):2123-35. doi: 10.1093/humrep/deu196. Epub 2014 Aug 14. Tournaye H, Dohle GR, Barratt CL. Fertility preservation in men with cancer. Lancet. 2014 Oct 4;384(9950):1295-301. doi: 10.1016/S0140-6736(14)60495-5. Review.