Meakin PJ, Harper AJ, Hamilton DL, Gallagher J, McNeilly AD, Burgess LA, Vaanholt LM, Bannon KA, Latcham J, Hussain I, Speakman JR, Howlett DR and Ashford ML (2012). Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice. Biochem J 441:285-296 Claret M, Smith MA, Knauf C, Al-Qassab H, Woods A, Heslegrave A, Piipari K, Emmanuel JJ, Colom A, Valet P, Cani PD, Begum G, White A, Mucket P, Peters M, Mizuno K, Batterham RL, Giese KP, Ashworth A, Burcelin R, Ashford ML, Carling D, Withers DJ. (2011) Deletion of LKB1 in Pro-Opiomelanocortin neurons impairs peripheral glucose homeostasis in mice. Diabetes 60:735-745 Deldicque L, Cani PD, Philp A, Raymackers J-M, Meakin PJ, Ashford MLJ, Delzenne NM, Francaux M, Baar K. (2010) The unfolded protein response is activated in skeletal muscle by high-fat feeding: potential role in the down-regulation of protein synthesis. Am J Physiol Endocrinol Metab 299:E695-705 Beall C, Piipari K, Al-Quassab H, Smith MA, Parker N, Carling D, Viollet B, Withers DJ, Ashford MLJ. (2010) Loss of AMP-activated protein kinase ?2 subunit in mouse ?-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia. Biochem J 429:323-333. Chowdhry S, Nazmy MH, Meakin PJ, Dinkova-Kostova AT, Walsh SV, Tsujita T, Dillon JF, Ashford MLJ, Hayes JD. (2010) Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis. Free Radic Biol Med 48:357-371. Al-Qassab H, Smith MA, Irvine EE, Guillermet-Guibert J, Claret M, Choudhury AI, Selman C, Piipari K, Clements M, Lingard S, Chandarana K, Bell JD, Barsh GS, Smith AJH, Batterham RL, Ashford MLJ, Vanhaesebroeck B, Withers DJ. (2009) Dominant role of the p110? isoform of PI3K over p110? in energy homeostasis regulation by POMC and AgRP neurons. Cell Metabolism 10:343-354. Ning K, Miller LC, Laidlaw HA, Watterson KR, Gallagher J, Sutherland C, Ashford MLJ. (2009) Leptin dependent phosphorylation of PTEN mediates actin restructuring and activation of ATP-sensitive K+ channels. J Biol Chem 284:9331-9340 Hisadome K, Smith MA, Choudhury AI, Claret M, Withers DJ, Ashford MLJ. (2009) 5-HT inhibition of rat insulin 2 promoter Cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus. Neuroscience. 159(1):83-93 Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LGD, Clements M, Al-Qassab H, Heffron H, Xu AW, Speakman JR, Barsh GS, Viollet B, Vaulont S, Ashford MLJ, Carling D, Withers DJ (2007) AMP kinase is essential for energy homeostasis regulation and glucose-sensing by POMC and AgRP neurons. J Clin Invest 117:2325-2336 Smith MA, Hisadome K, Al-Qassab H, Heffron H, Withers DJ, Ashford MLJ (2007) Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances. J Physiol 578, 425-438