B.Sc. University of Lisbon Biochemistry Ph.D. University of Wales Biological Sciences

Metabolic regulation is sufficient for global and robust coordination of glucose uptake, catabolism, energy production and growth in Escherichia coli.Millard, Pierre; Smallbone, Kieran; Mendes, Pedro PLoS computational biology 2017 Feb;13(2):e1005396 Minimum-noise production of translation factor eIF4G maps to a mechanistically determined optimal rate control window for protein synthesis.Meng, Xiang; Firczuk, Helena; Pietroni, Paola; Westbrook, Richard; Dacheux, Estelle; Mendes, Pedro; McCarthy, John E G Nucleic acids research 2016 Dec; COMODI: an ontology to characterise differences in versions of computational models in biology.Scharm, Martin; Waltemath, Dagmar; Mendes, Pedro; Wolkenhauer, Olaf Journal of biomedical semantics 2016 Jan;7(1):46 libChEBI: an API for accessing the ChEBI database.Swainston, Neil; Hastings, Janna; Dekker, Adriano; Muthukrishnan, Venkatesh; May, John; Steinbeck, Christoph; Mendes, Pedro Journal of cheminformatics 2016 Jan;811 Fitting Transporter Activities to Cellular Drug Concentrations and Fluxes: Why the Bumblebee Can Fly.Mendes, Pedro; Oliver, Stephen G; Kell, Douglas B Trends in pharmacological sciences 2015 Nov;36(11):710-23 Silence on the relevant literature and errors in implementation.Bastiaens, Philippe; Birtwistle, Marc R; Blüthgen, Nils; Bruggeman, Frank J; Cho, Kwang-Hyun; Cosentino, Carlo; de la Fuente, Alberto; Hoek, Jan B; Kiyatkin, Anatoly; Klamt, Steffen; Kolch, Walter; Legewie, Stefan; Mendes, Pedro; Naka, Takashi; Santra, Tapesh; Sontag, Eduardo; Westerhoff, Hans V; Kholodenko, Boris N Nature biotechnology 2015 Apr;33(4):336-9 Impact of kinetic isotope effects in isotopic studies of metabolic systems.Millard, Pierre; Portais, Jean-Charles; Mendes, Pedro BMC systems biology 2015 Jan;9(1):64 Zinc depletion regulates the processing and secretion of IL-1β.Summersgill, H; England, H; Lopez-Castejon, G; Lawrence, C B; Luheshi, N M; Pahle, J; Mendes, P; Brough, D Cell death & disease 2014 Jan;5e1040 Elevating vitamin C content via overexpression of myo-inositol oxygenase and l-gulono-1,4-lactone oxidase in Arabidopsis leads to enhanced biomass and tolerance to abiotic stresses.Lisko, Katherine A; Torres, Raquel; Harris, Rodney S; Belisle, Melinda; Vaughan, Martha M; Jullian, Berangère; Chevone, Boris I; Mendes, Pedro; Nessler, Craig L; Lorence, Argelia In vitro cellular & developmental biology. Plant : journal of the Tissue Culture Association 2013 Dec;49(6):643-655 A computational model of liver iron metabolism.Mitchell, Simon; Mendes, Pedro PLoS computational biology 2013 Nov;9(11):e1003299 The genome-wide early temporal response of Saccharomyces cerevisiae to oxidative stress induced by cumene hydroperoxide.Sha, Wei; Martins, Ana M; Laubenbacher, Reinhard; Mendes, Pedro; Shulaev, Vladimir PloS one 2013 Sep;8(9):e74939 A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes.Smallbone, Kieran; Messiha, Hanan L; Carroll, Kathleen M; Winder, Catherine L; Malys, Naglis; Dunn, Warwick B; Murabito, Ettore; Swainston, Neil; Dada, Joseph O; Khan, Farid; Pir, Pinar; Simeonidis, Evangelos; Spasic, Irena; Wishart, Jill; Weichart, Dieter; Hayes, Neil W; Jameson, Daniel; Broomhead, David S; Oliver, Stephen G; Gaskell, Simon J; McCarthy, John E G; Paton, Norman W; Westerhoff, Hans V; Kell, Douglas B; Mendes, Pedro FEBS letters 2013 Sep;587(17):2832-41 A new regulatory principle for in vivo biochemistry: pleiotropic low affinity regulation by the adenine nucleotides--illustrated for the glycolytic enzymes of Saccharomyces cerevisiae.Mensonides, Femke I C; Bakker, Barbara M; Cremazy, Frederic; Messiha, Hanan L; Mendes, Pedro; Boogerd, Fred C; Westerhoff, Hans V FEBS letters 2013 Sep;587(17):2860-7 An analysis of a 'community-driven' reconstruction of the human metabolic network.Swainston, Neil; Mendes, Pedro; Kell, Douglas B Metabolomics : Official journal of the Metabolomic Society 2013 Aug;9(4):757-764 A community-driven global reconstruction of human metabolism.Thiele, Ines; Swainston, Neil; Fleming, Ronan M T; Hoppe, Andreas; Sahoo, Swagatika; Aurich, Maike K; Haraldsdottir, Hulda; Mo, Monica L; Rolfsson, Ottar; Stobbe, Miranda D; Thorleifsson, Stefan G; Agren, Rasmus; B?lling, Christian; Bordel, Sergio; Chavali, Arvind K; Dobson, Paul; Dunn, Warwick B; Endler, Lukas; Hala, David; Hucka, Michael; Hull, Duncan; Jameson, Daniel; Jamshidi, Neema; Jonsson, Jon J; Juty, Nick; Keating, Sarah; Nookaew, Intawat; Le Novère, Nicolas; Malys, Naglis; Mazein, Alexander; Papin, Jason A; Price, Nathan D; Selkov, Evgeni; Sigurdsson, Martin I; Simeonidis, Evangelos; Sonnenschein, Nikolaus; Smallbone, Kieran; Sorokin, Anatoly; van Beek, Johannes H G M; Weichart, Dieter; Goryanin, Igor; Nielsen, Jens; Westerhoff, Hans V; Kell, Douglas B; Mendes, Pedro; Palsson, Bernhard ? Nature biotechnology 2013 May;31(5):419-25 A method for comparing multivariate time series with different dimensions.Tapinos, Avraam; Mendes, Pedro PloS one 2013 Jan;8(2):e54201 An in vivo control map for the eukaryotic mRNA translation machinery.Firczuk, Helena; Kannambath, Shichina; Pahle, Jürgen; Claydon, Amy; Beynon, Robert; Duncan, John; Westerhoff, Hans; Mendes, Pedro; McCarthy, John Eg Molecular systems biology 2013 Jan;9635 Path2Models: large-scale generation of computational models from biochemical pathway maps.Büchel, Finja; Rodriguez, Nicolas; Swainston, Neil; Wrzodek, Clemens; Czauderna, Tobias; Keller, Roland; Mittag, Florian; Schubert, Michael; Glont, Mihai; Golebiewski, Martin; van Iersel, Martijn; Keating, Sarah; Rall, Matthias; Wybrow, Michael; Hermjakob, Henning; Hucka, Michael; Kell, Douglas B; Müller, Wolfgang; Mendes, Pedro; Zell, Andreas; Chaouiya, Claudine; Saez-Rodriguez, Julio; Schreiber, Falk; Laibe, Camille; Dr?ger, Andreas; Le Novère, Nicolas BMC systems biology 2013 Jan;7116 Systematic construction of kinetic models from genome-scale metabolic networks.Stanford, Natalie J; Lubitz, Timo; Smallbone, Kieran; Klipp, Edda; Mendes, Pedro; Liebermeister, Wolfram PloS one 2013 Jan;8(11):e79195 What can we learn from global sensitivity analysis of biochemical systems?Kent, Edward; Neumann, Stefan; Kummer, Ursula; Mendes, Pedro PloS one 2013 Jan;8(11):e79244 The core control system of intracellular iron homeostasis: a mathematical model.Chifman, J; Kniss, A; Neupane, P; Williams, I; Leung, B; Deng, Z; Mendes, P; Hower, V; Torti, F M; Akman, S A; Torti, S V; Laubenbacher, R Journal of theoretical biology 2012 May;30091-9 Characterisation of multiple substrate-specific (d)ITP/(d)XTPase and modelling of deaminated purine nucleotide metabolism.Davies, Oluwafemi; Mendes, Pedro; Smallbone, Kieran; Malys, Naglis BMB reports 2012 Apr;45(4):259-64 Biochemical fluctuations, optimisation and the linear noise approximation.Pahle, Jürgen; Challenger, Joseph D; Mendes, Pedro; McKane, Alan J BMC systems biology 2012 Jan;686 Condor-COPASI: high-throughput computing for biochemical networks.Kent, Edward; Hoops, Stefan; Mendes, Pedro BMC systems biology 2012 Jan;691 Improving metabolic flux predictions using absolute gene expression data.Lee, Dave; Smallbone, Kieran; Dunn, Warwick B; Murabito, Ettore; Winder, Catherine L; Kell, Douglas B; Mendes, Pedro; Swainston, Neil BMC systems biology 2012 Jan;673